The Anti-inflammatory Activity of CeleryApium graveolensL. (Fam. Umbelliferae)

Apium GraveolensExtract Attenuates Adjuvant Induced Arthritis by Reducing Oxidative Stress

“…Recently, the pharmacological properties of A. graveolens have been associated with antioxidant activity (Aydemir and Becerik 2011;Jung et al 2011;Yao and Ren 2011;Li et al 2014) and the anti-inflammatory activity of A. graveolens extracts has also been investigated in vitro and in vivo. It was found that A. graveolens reduced carageenan induced-rat paw edema (Al-hindawi 1989;Baananou et al 2012) and mouse ear histamine vascular inflammation (Lewis et al 1985;Ramezani et al 2009). In addition, the extracts had a potent scavenging activity (Aydemir and Becerik 2011;Jung et al 2011;Li et al 2014) and also enhanced the activities of antioxidant enzymes (Popović et al 2006;Li et al 2014).…”

A toxicological investigation of a celery seed extract having anti-inflammatory activity

“…These extracts have also been found to variously affect prostaglandin production (K. D. Rainsford, 2001, unpublished observations). Aqueous extracts of celery stem have been found to have anti-inflammatory in the rat carrageenan foot paw edema model and in mouse ear histamine vascular inflammation (Lewis et al 1985). Essential oil components of celery seed have been shown to have antioxidant activity in vitro (Wei and Shibamoto 2007).…”

Antinociceptive and anti-inflammatory effects of isolated fractions fromApium graveolensseeds in mice

“…In Iranian traditional medicine, celery seeds are used to treat rheumatoid arthritis, gout, and kidney complaints (Zargari, 1990). The seeds are reported to possess antinociceptive, antiinflammatory properties (Lewis, 1985;Al-Hindawi et al, 1989;Atta & Alkofahi, 1998) and antioxidant properties (Lewis et al, 1985;Momin et al, 2002). A previous study in our laboratory has revealed that hydroalcohol extract of celery seeds has anti-inflammatory and antinociceptive activity (Nasri et al, 2007).…”