The Anti-inflammatory Activity of <i>Scutellaria rivularis</i> Extracts and Its Active Components, Baicalin, Baicalein and Wogonin

Lin, Chun‐Ching; Shieh, Den-En

doi:10.1142/s0192415x96000050

Cited by 284 publications

(165 citation statements)

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“…Previous reports suggested that baicalin could inhibit tissue's inflammatory response through decreasing the release of TNF-α, IL-1 β, IL-6 and other factors which had been confirmed that might enhance osteoclast function and promote bone resorption directly or indirectly [11][12][13]. Wang GF [26] showed that the expression of RANKL mRNA stimulated by IL-1β was inhibited by baicalin after being treated for 12h and the inhibition reached its maximum at 48h.…”

Section: Discussionmentioning

confidence: 90%

“…It had been reported that baicalin exhibited antibacterial, anti-inflammatory and analgesic effects [5][6][7][8][9][10]. Many scholars found that baicalin could inhibit tissue's inflammatory response through decreasing the release of TNF-α, IL-1 β, IL-6 and other factors which had been confirmed that might enhance osteoclast function and promote bone resorption directly or indirectly [11][12][13].…”

Section: Introductionmentioning

confidence: 96%

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Influence of Baicalin on Alveolar Bone Resorption in Rat Experimental Periodontitis

Chen

Yang²

2008

Sci. Pharm.

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Objective: In this study, the effects of baicalin -a flavonoid purified from Scutellaria baicalensis. Georgi, Scutellaria L. -on alveolar bone resorption in rat experimental periodontitis were examined. Method: 12 Sprague-Dawley rats (SD rats) were randomly divided into four groups: Group A1, A2, B and C. Except for Group C -the control group-, Group A1, A2 and B were used to establish the rat periodontitis model by repeat injection of Lipopolysaccharide (LPS). At the same time, Group A1 and A2 were injected with baicalin of different concentration. 9 days later, the maxillae were extracted and analyzed using micro computerized tomography (micro-CT), followed by histological analysis. Result: Micro-CT images showed that alveolar bone resorption was severely induced around the molar by repeat injection of LPS. Treatment with high-dose baicalin (1.0 μg / ml) clearly recovered alveolar bone resorption, meanwhile, low-dose baicalin(0.1 μg / ml) showed a similar but weaker effect. Histological examination clarified that the number of osteoclast was dose dependently decreased by baicalin treatment. Conclusion: These findings suggest that baicalin may inhibit the alveolar bone loss in periodontitis effectively. Keywords

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 96%

Influence of Baicalin on Alveolar Bone Resorption in Rat Experimental Periodontitis

Chen

Yang²

2008

Sci. Pharm.

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“…Parts of the compounds have been reported to have the pharmacological activity related to H1 receptor inhibition by literatures. Lin found that Baicalein (ID 2102) and Baicalin (ID 2106) extracted from Scutellaria rivularis have the anti-inflammatory activity against carrageenan-induced paw edema in rats [22]. Cortisone (ID 6853) and cuscohygrine (ID 1836) were discovered to have the active of anti-allergy [23], [24].…”

Section: Top Scoring Compoundsmentioning

confidence: 99%

Pharmacophore Modelling, Molecular Docking and Virtual Screening for Histamine H1 Receptor Antagonists from Traditional Chinese Medicine

Wang¹,

Ren²,

Xiang³

et al. 2013

IJBBB

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Abstract-This investigation was performed to identify histamine H1-receptor antagonists from traditional Chinese medicine through virtual screening based on pharmacophore and molecular docking. First, the pharmacophore models were generated though ten known H1 receptor antagonists. The models were validated by a test database and shown to have good performance in external validation. The best pharmacophore was employed to screen Traditional Chinese Medicine Database, which resulting in a hit list of 421 compounds. Then, the hits were subjected to molecular docking for further refinement. An empirical scoring function was used to evaluate the affinity of the compounds and the target protein.Parts of compounds with high docking scores have been reported to have the related pharmacological activity in the literatures. The findings indicated that virtual screening based on pharmacophore and molecular docking can provide a helpful tool to reveal the active ingredients from Chinese herbs. It can be used for identification of novel H1 antagonists from Traditional Chinese Medicine.Index Terms-Histamine H1-receptor, virtual screening, traditional chinese medicine, active natural ingredients identification.

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“…It is mainly distributed in southern China and has been used as an antitumor agent for lung cancer, digestive system cancer, hepatoma, breast cancer, and chorioepithelioma as well as an anti-inflammatory agent and a diuretic in China and Korea [1][2][3][4][5][6][7][8][9] . Extracts from S. barbata (ESB) have in vitro growth inhibitory effects on a number of human cancers including leukemia, colon cancer, hepatoma and skin cancer [4][5][6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3

Dai¹,

Wang²,

Li³

et al. 2008

WJG

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of cell cycle, the percentage of cells in S phase was significantly decreased, while the percentage of cells in G 1 phase was increased. Flow cytometry assay also showed that ESB had a positive effect on apoptosis. Typical apoptotic morphologies such as condensation and fragmentation of nuclei and blebbing membrane of apoptotic cells could be observed under transmission electron microscope and fluorescence microscope. To further investige the molecular mechanism behind ESB-induced apoptosis, ESB-treated cells rapidly lost their mitochondrial transmembrane potential, released mitochondrial cytochrome C into cytosol, and induced caspase-3 activity in a dose-dependent manner. CONCLUSION: ESB can effectively inhibit the proliferation and induce apoptosis of H22 cells involving loss of mitochondrial transmembrane potential, release of cytochrome C, and activation of caspase-3. INTRODUCTIONScutellaria barbata D.Don (S. barbata) is a perennial herb, also known as Ban-Zhi-Lian (barbat sskullcap) in traditional Chinese medicine. It is mainly distributed in southern China and has been used as an antitumor agent for lung cancer, digestive system cancer, hepatoma, breast cancer, and chorioepithelioma as well as an anti-inflammatory agent and a diuretic in China and Korea [1][2][3][4][5][6][7][8][9] . Extracts from S. barbata (ESB) have in vitro growth inhibitory effects on a number of human cancers including leukemia, colon cancer, hepatoma and skin cancer [4][5][6][7][8][9][10] . However, its antitumor mechanism still remains unclear.It was reported that many Chinese herbs have anticancer properties and induce apoptosis [11] . Three apoptotic pathways have been addressed, including the mitochondrial pathway [12,13] , death receptor pathway [14] , and endoplasmic reticulum stress-mediated apoptosis pathway [15] . The mitochondrial pathway initiates apoptosis in most physiological and pathological situations. Permeabilization outside mitochondrial membrane plays the most important role in mitochondrial apoptosis. In the mitochondria-initiated pathway, mitochondria undergoing permeability transition release apoptogenic proteins such as cytochrome C or apoptosis-inducing factor from the mitochondrial intermembrane space into the cytosol [16] . Released cytochrome C can activate caspase-9, and activated caspase-9 in turn cleaves and activates executioner caspase-3. After caspase-3 activation, some specific substrates for caspase-3 such as poly (ADP-ribose) and polymerase (PARP) are cleaved, and eventually lead to apoptosis [17] . In this study, S. barbata extract showed anti-tumor activity in vitro and could inhibit the growth of mouse H22 hepatoma cells by inhibiting cell apoptosis and cytotoxic effects, demonstrating that the extract from S. barbata can strongly inhibit cell proliferation and induce apoptosis of H22 cells through the mitochondrial dysfunction pathway. MATERIALS AND METHODSReagents and animals N e w b ov i n e s e r u m ( G i b c o, U S A ) , R P M I -1 6 4 0 medium(Gibco, USA), propidium iodide (PI) (Sigma, ...

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The Anti-inflammatory Activity of Scutellaria rivularis Extracts and Its Active Components, Baicalin, Baicalein and Wogonin

Cited by 284 publications

References 0 publications

Influence of Baicalin on Alveolar Bone Resorption in Rat Experimental Periodontitis

Influence of Baicalin on Alveolar Bone Resorption in Rat Experimental Periodontitis

Pharmacophore Modelling, Molecular Docking and Virtual Screening for Histamine H1 Receptor Antagonists from Traditional Chinese Medicine

Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3

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