The Anti-Inflammatory and Antioxidant Effects ofSalvia officinalison Lipopolysaccharide-Induced Inflammation in Rats

Abstract

Salvia officinalis, which has a high phenolic acid and flavonoid content, is a powerful antioxidant and anti-inflammatory herb. Inflammation plays an important role in the pathophysiology of many diseases and could cause damage by means of oxidative stress. The aim of this study was to investigate the anti-inflammatory and antioxidant activity of S. officinalis formed lipopolysaccharide (LPS)-induced experimental inflammation model. Four- to five-month-old 42 female Wistar albino rats were divided into six groups. Three groups were administered intraperitoneally 1 mg/kg LPS. Twenty-four hours after injection of LPS, 10 and 30 mg/kg S. officinalis extract were given orally to treatment groups. Pulmonary and hepatic F-fluoro-deoxy-D-glucose (F-FDG) uptake was calculated to determine the status of inflammation by 18F-fluoro-deoxy-D-glucose-positron emission tomography (FDG-PET) scan. Antioxidant enzyme activities and nitric oxide (NO) and malondialdehyde (MDA) levels were determined. Nuclear factor-kappa B (NF-κB) and tumor necrosis factor-alpha (TNF-α) levels were also detected in serum. As a result, lung and liver F-FDG uptake was found to be higher in the inflammation group than control group. MDA levels in erythrocyte and all tissue samples (liver, lung, and kidney) were found to be significantly higher compared to treatment groups. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase activities of the inflammation group in the liver, lung, kidney tissues, and erythrocyte SOD and CAT activities were determined to significantly lower than groups treated with S. officinalis. Increased NO, NF-κB, and TNF-α levels were found in the inflammation group. S. officinalis has been observed to have useful effects on LPS-induced inflammation and oxidative stress in rats.

Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches

“…Moreover, recently our group reported that the administration of R. officinalis to zebrafish abolished AChE alteration and brain oxidative stress induced by Sco [38]. S. officinalis has been observed to have anti-inflammatory and antioxidant effects on lipopolysaccharide (LPS)-induced inflammation in rats [39] and attenuated bleomycin-induced oxidative stress and lung fibrosis in rats [40]. In line with early results, we assume that the presence of the bioactive compounds within the MO may potentially lead to its increased antioxidant potential.…”

Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways

“…It mainly due to uncontrolled inflammatory cytokines secretion and obvious neutrophils infiltration in liver, and ultimately lead to inflammation and oxidative stress (Li et al, 2016). Inflammation and oxidative stress are considered as an extremely related event with the pathological process of ALI (Kolac et al, 2017; Jung et al, 2018). Under stimulation of the LPS, the classical NF-κB signaling pathway is activated to release many pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α, thereby further aggravate inflammation damage in liver (Li L. et al, 2017).…”

Current State of the Art on the Antioxidant Activity of Sage (Salvia spp.) and Its Bioactive Components

“…Both SOD and CAT activities were significantly lower in groups treated with S. officinalis extract. Moreover, enhanced nitric oxide, NF-κB, and TNF-α levels were found in the inflammation group [82].…”