The Anti‐Inflammatory Effects of Invigorating Kidney and Supplementing Qi Chinese Herbal Formulae in Asthma Patients

Abstract

Background The theories of Shen-reinforcement and Qi-supplementation are important in asthma treatment based on traditional Chinese medicine theories. Early studies suggested that Invigorating Kidney and Supplementing Qi herbal formulae, Bu Shen Fang Chuan (BSFC) and Bu Shen Yi Qi (BSYQ), conveyed promising results in asthma treatment. However, the efficacy and safety of the formulae need to be further investigated by a randomized double-blind clinical trial. Methods 328 eligible patients were randomly sent to BSFC, BSYQ, and placebo group. The two formulae were received as add-on therapy. The primary endpoints were rate of asthma exacerbation and Hamilton Rating Scale for Depression (HAM-D) score. The secondary endpoints included HPA axis function and inflammatory cytokine production profile. All indexes were measured before and after treatment. Results The primary endpoints were not improved in both groups; however, the depression levels of subgroup patients with HAM-D score > 5 were improved in BSFC group. HPA axis functions and inflammatory cytokines level were also improved by two formulae. The incidences of adverse events were similar among groups. Conclusions The two formulae had multiple advantage effects on neuroendocrine-immune system. They are worth used as a replacement therapy in asthma. Trial Registration This trial is registered with clinical trial number ChiCTR-PRC-09000529.

Traditional medicines for asthma in children and adults: A systematic review of placebo‐controlled studies

“…One study reported fewer exacerbations in the AKL1 group but the difference was not significant. In a three‐arm study of two TMs for mild‐moderate asthma there were no significant differences between groups . The mean change in asthma attacks in the 12‐week study of children was significant in favour of the TM.…”

“…Two participants in a TM group had abnormal liver enzymes . Three had abnormal liver function after treatment (TM 2/C1) . There was no mention of interactions between TMs and conventional medications in any study.…”

“…Blinding of personnel in six studies was judged unclear . Seven studies stated that the outcome assessments were blinded . Incomplete outcome data and selective outcome reporting were of low risk in 15 RCTs and unclear in one brief report .…”

“…The remaining 17 studies investigated chronic asthma, with seven in children only, seven in adults only and one in adults and children . One did not specify the age range but the mean age suggested adults . Another did not report age‐related data…”

“…Some studies had 30 or fewer participants per group, and two mentioned that they were underpowered . Conversely, three studies had over 100 participants per group . Durations were short in some studies but eight were of 6 months and one included a 6‐month follow‐up .…”