The anti-inflammatory influence of Cinnamomum burmannii against multi-walled carbon nanotube-induced liver injury in rats

HelmyAbdou, Khaled Abbas; Ahmed, Rasha R.; Ibrahim, Marwa A.; Abdel-Gawad, Doaa Ramadan I.

doi:10.1007/s11356-019-06707-5

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…It has been reported that oxidation-shortened amino-functionalized MWNT and amino-functionalized MWNT induced a transient increase in almost all pro-inflammatory cytokines ( Bardi et al, 2013 ). Rats exposed to MWCNTs showed an increase in the expression of IL-1β compared with a control group, while the rate of TNF-α expression in male albino rats was significantly increased after MWCNT exposure ( Kido et al, 2014 ; HelmyAbdou et al, 2019 ). However, another study revealed a decrease in the rate of TNF-α expression after MWCNT exposure ( Kermanizadeh et al, 2014 ).…”

Section: Inorganic Npsmentioning

confidence: 89%

“…After 48 h treatment, the samples were fixed using 4% PFA. albino rats was significantly increased after MWCNT exposure (Kido et al, 2014;HelmyAbdou et al, 2019). However, another study revealed a decrease in the rate of TNF-α expression after MWCNT exposure (Kermanizadeh et al, 2014).…”

Section: Nanocarbon Lipid-based Npsmentioning

confidence: 94%

“… Kermanizadeh et al (2014) demonstrated downregulation of IL-1β after MWCNT exposure, indicating the inhibition of neuroinflammation. Meanwhile, others found an increase in the expression of IL-1β in mice following exposure to MWCNTs ( Hamilton et al, 2013 ; Kido et al, 2014 ; HelmyAbdou et al, 2019 ). It has been reported that oxidation-shortened amino-functionalized MWNT and amino-functionalized MWNT induced a transient increase in almost all pro-inflammatory cytokines ( Bardi et al, 2013 ).…”

Section: Inorganic Npsmentioning

confidence: 99%

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Nanoparticles: A Hope for the Treatment of Inflammation in CNS

Zhu

et al. 2021

Front. Pharmacol.

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Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a main hallmark of common neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), among others. The over-activated microglia release pro-inflammatory cytokines, which induces neuronal death and accelerates neurodegeneration. Therefore, inhibition of microglia over-activation and microglia-mediated neuroinflammation has been a promising strategy for the treatment of neurodegenerative diseases. Many drugs have shown promising therapeutic effects on microglia and inflammation. However, the blood–brain barrier (BBB)—a natural barrier preventing brain tissue from contact with harmful plasma components—seriously hinders drug delivery to the microglial cells in CNS. As an emerging useful therapeutic tool in CNS-related diseases, nanoparticles (NPs) have been widely applied in biomedical fields for use in diagnosis, biosensing and drug delivery. Recently, many NPs have been reported to be useful vehicles for anti-inflammatory drugs across the BBB to inhibit the over-activation of microglia and neuroinflammation. Therefore, NPs with good biodegradability and biocompatibility have the potential to be developed as an effective and minimally invasive carrier to help other drugs cross the BBB or as a therapeutic agent for the treatment of neuroinflammation-mediated neurodegenerative diseases. In this review, we summarized various nanoparticles applied in CNS, and their mechanisms and effects in the modulation of inflammation responses in neurodegenerative diseases, providing insights and suggestions for the use of NPs in the treatment of neuroinflammation-related neurodegenerative diseases.

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Section: Inorganic Npsmentioning

confidence: 89%

Section: Nanocarbon Lipid-based Npsmentioning

confidence: 94%

Section: Inorganic Npsmentioning

confidence: 99%

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Nanoparticles: A Hope for the Treatment of Inflammation in CNS

Zhu

et al. 2021

Front. Pharmacol.

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“…Freshly prepared 1 ml diphenylamine reagent (1.5 g of diphenylamine dissolved in 100 ml acetic acid, 1.5 ml of conc. sulfuric acid and 0.50 ml of acetaldehyde (16 mg/ml)) was added in each sample, tubes were allowed to stand overnight at room temperature and OD was recorded at 600 nm [36]. DNA laddering percentage was calculated as: % DNA laddering [S/(S + P)] × 100.…”

Section: Dna Laddering Assaymentioning

confidence: 99%

The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens

et al. 2020

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The present study aimed to evaluate what dosage of gold nanoparticles (GNPs) would improve growth performance, antioxidant levels and immune defense in broiler chickens. The experiment was carried out on 90 one-day-old mixbred Cobb chicks. The birds were allocated into three groups with three replicates. Group (1) kept as a negative control. Groups (2) and (3) received 5, 15 ppm GNPs via drinking water weekly for 35 days of chicks’ life. Blood samples were collected at 8, 15, 22 and 36 days for oxidative stress evaluations and immunological studies. The birds were slaughtered at the ages of 36 days and thymus, spleen, busa of Fabricius and liver were collected for histopathological description, RT-PCR analysis and DNA fragmentation assay. Our results confirmed that adding of 15ppm GNPs in drinking water were induced remarkable blood oxidative stress damage, histopathological alterations, up-regulation of IL-6, Nrf2 gene expression, and DNA fragmentation in the examined immune organs of the broiler chickens as well as a significant reduction in the antibody titer against Newcastle (ND) and avian influenza (AI) viruses were noticed. On the other hand, the group received 5 ppm GNPs noticed better growth performance with the enhancement of the final food conversion ratio (FCR) without any significant difference in the previous toxicological and immunological parameters compared with the control groups. We suggest that feeding of 5ppm GNPs could improve the antioxidant capacity, immunity and performance in poultry but further food quality assurance tests are required in the future to confirm its safety for people.

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“…The clove EO has various bioactivity potentials including antimicrobial [12][13][14], antifungals [15][16][17], anticancer [18], antiprotozoal [19], analgesic [20] and anti-inflammatory [21][22][23]. At the same time, cinnamaldehyde derived from cinnamon EO has antiproliferative, antibacterial, and antimicrobial activity [24][25][26]. This bioactivity predicts influenced by eugenol (C10H12O2) and cinnamaldehyde (C9H8O) content as the major compound.…”

Section: Introductionmentioning

confidence: 99%

Natural Isothiocyanate Anti-Malaria: Molecular Docking, Physicochemical, Adme, Toxicity and Synthetic Accessibility Study of Eugenol and Cinnamaldehyde

et al. 2021

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Objective: This study aims to evaluate novel compounds of isothiocyanate (ITC) based on eugenol and cinnamaldehyde derivatives as the drug candidate of Plasmodium falciparum anti-malaria using in silico method, physicochemical, pharmacokinetics, toxicity, and synthetic accessibility prediction. This present study also describes molecular docking and pharmacoinformatics of natural ITC in Moringa oleifera leaves. Methods: A series of novel ITC compounds (3, 5, and 6) were designed and analyzed with a series of natural ITC compounds (7, 8, 9, 10) for P. falciparum anti-malaria. This research is descriptive qualitative and uses the reverse molecular docking method, proving the biological activity of compounds theoretically using software and database information. Results: Molecular docking study showed that compound 6 exhibits binding affinity (-5.3 Kcal/mol) on Van der Waals interaction with the residual active site (His159, Cys25) of cysteine protease. All designed ITC compounds are obeyed the Lipinski and Veber Rule, have a well-brain penetrant character and have a medium risk for mutagenic, tumorigenic, and reproductive prediction. They are also in the simple rate of synthetic accessibility (SA) estimation. In regards to natural ITCs, they all have better assay characteristics except the SA. Conclusion: Molecular docking, physicochemical, pharmacokinetic, and toxicity studies show that methyl eugenol isothiocyanate and cinnamaldehyde isothiocyanate are promising anti-malaria compounds. Substituents of hydroxy, acetate and tetrahydropyran groups in the building block ring are suggested for better in silico profiles enhancement.

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The anti-inflammatory influence of Cinnamomum burmannii against multi-walled carbon nanotube-induced liver injury in rats

Cited by 18 publications

References 41 publications

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens

Natural Isothiocyanate Anti-Malaria: Molecular Docking, Physicochemical, Adme, Toxicity and Synthetic Accessibility Study of Eugenol and Cinnamaldehyde

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