The anti-inflammatory potential of berberine in vitro and in vivo

Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte

“…Because both TNF-and IL-6 have C/EBP binding site on their promoter regions, their expression levels are regulated by C/EBP family, including C/EBP-, C/EBP-and C/EBP- (Akira et al, 1990;Pope et al, 1994). In other studies, BBR has an anti-inflammatory effect by stimulating COX-2 expression in human oral epidermoid cancer cells (Kuo et al, 2004). Because COX-2 plays a key role in prostaglandins synthesis, which is elevated in inflammation, it would be meaningful to investigate the change of COX level and activity by BBR treatment in adipocytes.…”

“…Studies have shown that BBR, the major component of these herbs, has many pharmacological effects including inhibition of adipocyte differentiation, anti-cancer effects, anti-microbial effects, LDL-lowering effects and anti-inflammatory potential (Amin, 1969;Huang and Williams, 1999;Anis et al, 2001;Zhou, 2003;Kong et al, 2004;Kuo et al, 2004). But the role of BBR in inhibition of adipocyte differentiation and the mechanism of anti-inflammatory activity have not yet been clarified.…”

Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells

“…The anti-inflammatory effect of C. chinensis collected at different times correlates positively with these five alkaloids contents (Li et al, 2015). Berberine plays a key role in the modulation of inflammatory responses through inhibition of NF-κB and AP-1 binding (Kuo, et al, 2004;Jiang et al, 2011). Palmatine has been shown to exhibit anti-inhibitory activity in a serotonin-induced model of paw edema and attenuate D-galactosamine/LPS-induced fulminant hepatic failure in mice (Kupeli et al, 2002;Lee et al, 2010a).…”

Simultaneous analysis of protoberberine and indolequinoline alkaloids in Zuojin pill extract by high-performance liquid chromatography

“…C. rhizoma contains a number of protoberberine alkaloids, such as coptisine, palmatine, and berberine [6][7][8]. Among the compounds analyzed, berberine has been shown to possess anti-inflammatory [9,10], antidiarrhetic, antimalarial [11], and antimicrobial [12] activities. In addition, coptisine and palmatine were previously tested for skin permeation enhancement [13] and antimicrobial activities with promising results [12].…”