The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth

Ye, Changchang; Katagiri, Seiji; Matsuda, Naoyuki; Bharti, Pariksha; Kobayashi, Hiroaki; Takeuchi, Yasuo; Momohara, Yoshihito; Sekiguchi, Masaki; Takamine, Satoko; Nagasawa, Toshiyuki; Izumi, Yuichi

doi:10.1007/s00404-013-2741-z

Cited by 25 publications

(22 citation statements)

References 32 publications

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“…, Ye et al. ). Porphyromonas gingivalis is an anaerobic, Gram‐negative bacterium and a causative agent of chronic periodontitis that is associated with several systemic sequelae, including pregnancy complications (Leon et al.…”

Section: Discussionmentioning

confidence: 99%

“…Infection with periodontal bacteria has been reported to be an important indicator of poor pregnancy outcome, particularly pre-term and/or low birth weight infants (Chan et al 2010, Hirano et al 2012, Ercan et al 2013, Santa Cruz et al 2013, Ye et al 2013. Porphyromonas gingivalis is an anaerobic, Gram-negative bacterium and a causative agent of chronic periodontitis that is associated with several systemic sequelae, including pregnancy complications (Leon et al 2007).…”

Section: Discussionmentioning

confidence: 99%

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Increased infection with key periodontal pathogens during gestational diabetes mellitus

Gogeneni

Buduneli

Ceyhan-Öztürk

et al. 2015

J Clinic Periodontology

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Aim Gestational diabetes mellitus (GDM), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden. Materials and Methods Four case–control groups (n = 117) were recruited, (1) No gingivitis, No GDM (n = 27); (2) Gingivitis, No GDM (n = 31); (3) No gingivitis, GDM (n = 21); and (4) Gingivitis, GDM (n = 38). Oral infection with three key periodontal pathogens was determined by PCR. Systemic inflammation was determined by quantification of CRP by EIA. Results Gingivitis during pregnancy was associated with oral infection with Porphyromonas gingivalis, Filifactor alocis and Treponema denticola and combinations thereof (all p < 0.01). GDM was also associated with increased infection with individual and multiple oral pathogens (all p < 0.05). Gingivitis during pregnancy led to a 325% increase in systemic CRP (mean, 2495 versus 8116 ng/ml, p < 0.01). Conclusions Diabetes and gingivitis act in concert to increase risk biomarkers for poor pregnancy outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Gogeneni

Buduneli

Ceyhan-Öztürk

et al. 2015

J Clinic Periodontology

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“…The association between P. gingivalis in saliva and fertility problems suggests that some specific bacterial features are involved, independent of the extent of clinical infection and inflammation. The same bacterial antigens that explain the association between P. gingivalis infection and adverse pregnancy outcomes in humans [23,24] and in animal models [25,26] may also delay conception. The underlying mechanism between P. gingivalis virulence and conception may also include more specific features, as recently shown with aspiration pneumonia by P. gingivalis in a mouse model: gingipains were crucial for the inflammatory response in the lungs, making a clear contribution to the development of pneumonia [27].…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis may interfere with conception in women

Paju

Oittinen

Haapala

et al. 2017

Journal of Oral Microbiology

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In this observational and prospective study, we investigated if microbiological and serological markers of periodontitis associated with conception in 256 non-pregnant women (Mage = 29.2 years; range 19–42 years). Clinical oral and gynecological examinations were performed, major periodontal pathogens in the saliva were detected, and serum and saliva antibodies against major periodontal pathogens were analyzed. The follow-up period for becoming pregnant was 12 months. Porphyromonas gingivalis was significantly (p = 0.032) more frequently detected in the saliva among those who did not become pregnant (8.3%) than among those who became pregnant (2.1%). The median levels of salivary P. gingivalis immunoglobulin A (IgA; p = 0.006) and IgG (p = 0.007) antibodies were higher among those who did not become pregnant compared to those who became pregnant. Hazard ratios (HR) for not becoming pregnant were HR = 3.75 (95% confidence interval [CI] 1.01–13.9; p = 0.048) if the subject was polymerase chain reaction–positive for P. gingivalis with high salivary antibodies against it, and HR = 1.62 (95% CI 1.03–2.54; p = 0.035) if she had high levels of serum P. gingivalis IgA and signs of periodontal infection. P. gingivalis associated with no success in getting pregnant.

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“…Ye et al examined the effect of A. actinomycetemcomitans infection on threatened preterm labor (TPL) and preterm birth (PB), and reported that the presence of anti-SIRVYK IgG antibodies was significantly associated with TPL diagnosis [33]. The PB rate was higher in the anti-SIRVYK IgG antibody "4median" group than in the "r median" group.…”

Section: Molecular Mimicrymentioning

confidence: 99%

Host–microbial co-evolution in periodontitis associated with Aggregatibacter actinomycetemcomitans infection

Nagasawa

Shimizu

Kato

et al. 2014

Journal of Oral Biosciences

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The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth

Abstract: Infection with P. gingivalis and the antibody response to SIRVYK might be associated with TPL and PB.

Cited by 25 publications

References 32 publications

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Porphyromonas gingivalis may interfere with conception in women

Host–microbial co-evolution in periodontitis associated with Aggregatibacter actinomycetemcomitans infection

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