The Anti-Rotaviral and Anti-Inflammatory Effects of Hyrtios and Haliclona Species

Koh, Su-Im; Shin, Hea-Soon

doi:10.4014/jmb.1603.03079

Cited by 5 publications

(3 citation statements)

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“…Using bioactivity-guided fractionation, eight isoquinolinequinones (1)(2)(3)(4)(5)(6)(7)(8), including four new derivatives, were isolated ( Figure 1). Eight compounds, with a 5,8-dioxo-5,8dihydroisoquinoline moiety, were isolated from a sponge Haliclona sp.…”

Section: Resultsmentioning

confidence: 99%

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Isoquinolinequinone Derivatives from a Marine Sponge (Haliclona sp.) Regulate Inflammation in In Vitro System of Intestine

Kim

et al. 2021

Marine Drugs

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Using bio-guided fractionation and based on the inhibitory activities of nitric oxide (NO) and prostaglandin E2 (PGE2), eight isoquinolinequinone derivatives (1–8) were isolated from the marine sponge Haliclona sp. Among these, methyl O-demethylrenierate (1) is a noble ester, whereas compounds 2 and 3 are new O-demethyl derivatives of known isoquinolinequinones. Compound 8 was assigned as a new 21-dehydroxyrenieramycin F. Anti-inflammatory activities of the isolated compounds were tested in a co-culture system of human epithelial Caco-2 and THP-1 macrophages. The isolated derivatives showed variable activities. O-demethyl renierone (5) showed the highest activity, while 3 and 7 showed moderate activities. These bioactive isoquinolinequinones inhibited lipopolysaccharide and interferon gamma-induced production of NO and PGE2. Expression of inducible nitric oxide synthase, cyclooxygenase-2, and the phosphorylation of MAPKs were down-regulated in response to the inhibition of NF-κB nuclear translocation. In addition, nuclear translocation was markedly promoted with a subsequent increase in the expression of HO-1. Structure-activity relationship studies showed that the hydroxyl group in 3 and 5, and the N-formyl group in 7 may be key functional groups responsible for their anti-inflammatory activities. These findings suggest the potential use of Haliclona sp. and its metabolites as pharmaceuticals treating inflammation-related diseases including inflammatory bowel disease.

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Section: Resultsmentioning

confidence: 99%

“…In the previous study, anti-inflammation of the extract of Haliclona sp. was reported in LPS-activated Raw 264.7 macrophages [7]. The extract of Haliclona sp.…”

Section: Introductionmentioning

confidence: 94%

Isoquinolinequinone Derivatives from a Marine Sponge (Haliclona sp.) Regulate Inflammation in In Vitro System of Intestine

Kim

et al. 2021

Marine Drugs

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“…Methanol extracts of Hyrtios and Haliclona species (Demospongiae), collected near Kosrae Island, Micronesia, Central Pacific, were examined for their activities in the LPS (1 μg/mL)-treated for 24 h Raw 264.7 cells [93]. Both extracts (25, 50, and 100 μg/mL each) exhibited dose-dependent ability to reduce NO generation, and at concentration of 10 μg/mL, the extracts inhibited the proinflammatory cytokine IL-1β production, whose level characterizes M1 macrophage phenotype [12].…”

Section: Poriferamentioning

confidence: 99%

Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates

Долматова

Dolmatov

2020

Marine Drugs

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Macrophages play a fundamental role in the immune system. Depending on the microenvironment stimuli, macrophages can acquire distinct phenotypes characterized with different sets of the markers of their functional activities. Polarization of macrophages towards M1 type (classical activation) is involved in inflammation and the related progression of diseases, while, in contrast, alternatively activated M2 macrophages are associated with the anti-inflammatory mechanisms. Reprogramming macrophages to switch their phenotypes could provide a new therapeutic strategy, and targeting the M1/M2 macrophage balance is a promising current trend in pharmacology. Marine invertebrates are a vast source of the variety of structurally diverse compounds with potent pharmacological activities. For years, a large number of studies concerning the immunomodulatory properties of the marine substances have been run with using some intracellular markers of immune stimulation or suppression irrespective of the possible application of marine compounds in reprogramming of macrophage activation, and only few reports clearly demonstrated the macrophage-polarizing activities of some marine compounds during the last decade. In this review, the data on the immunomodulating effects of the extracts and pure compounds of a variety of chemical structure from species of different classes of marine invertebrates are described with focus on their potential in shifting M1/M2 macrophage balance towards M1 or M2 phenotype.

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Approaches of marine compounds and relevant immune mediators in Autism Spectrum Disorder: Opportunities and challenges

Santos,

Obando,

Leite

et al. 2024

European Journal of Medicinal Chemistry

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The Anti-Rotaviral and Anti-Inflammatory Effects of Hyrtios and Haliclona Species

Cited by 5 publications

References 0 publications

Isoquinolinequinone Derivatives from a Marine Sponge (Haliclona sp.) Regulate Inflammation in In Vitro System of Intestine

Isoquinolinequinone Derivatives from a Marine Sponge (Haliclona sp.) Regulate Inflammation in In Vitro System of Intestine

Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates

Approaches of marine compounds and relevant immune mediators in Autism Spectrum Disorder: Opportunities and challenges

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