In earthquake-prone areas, pile-anchor structures are widely employed for slope reinforcement due to their reliable performance. Current research has primarily focused on static and quasi-static analyses of slopes reinforced by using pile-anchor structures, with limited investigation into their dynamic response. In this work, the finite element method (FEM) is used to study the dynamic behavior of a pile-anchor slope system, and the extended finite element method (XFEM) is used to simulate the progressive failure processes of piles. Three different reinforcement schemes, which include no support, pile support, and pile-anchor support, are considered to examine the performance of the pile-anchor structure. The simulation results suggest that the pile-anchor structure displays a reduction of 39.6% and 40.6% in the maximum shear force and bending moment of the piles, respectively, compared to the pile structure. The XFEM is utilized to model the progressive failure process of the piles subjected to seismic loading. We find that crack initiation in the pile body near the slip surface, for both the pile supported and the pile-anchor supported conditions, occurs when the peak ground acceleration arrives. Crack growth in the piles completes in a very short period, with two distinct increments of crack area observed. The first increment occurs when the peak ground acceleration arrives and is significantly larger than the second increment. Consequently, for the seismic design of piles, it is necessary to strengthen the pile body around slip surfaces. The novelty of this paper is that we realize the simulation of crack initiation and propagation in piles subjected to seismic loading.