The anti‐ulcerogenic activity of the unripe plantain banana (Musa species)

Abstract

IVarious preparations of dried unripe plantain banana were found to be anti-ulcerogenic against aspirin-induced ulceration in the rat and were effective both as a prophylactic treatment and in healing ulcers already induced by aspirin. Ripe fruit bananas were inactive. 2 The active factor(s) were water soluble and were concentrated by extraction to approximately three hundred times that in the dried banana powder. 3 The anti-ulcerogenic action of banana preparations appears to be due to their ability to stimulate the growth of gastric mucosa. 4 Aluminium hydroxide, cimetidine, prostaglandin E2, N6, 02-dibutyryl adenosine 3',5' cyclic monophosphate but not 5 -hydroxytryptamine were also anti-ulcerogenic when used prophylactically in rats but were ineffective in healing ulcers already formed by aspirin. These substances did not stimulate the growth of gastric mucosa.

Antioxidant effcacy of unripe banana (Musa acuminata Colla) peel extracts in sunflower oil during accelerated storage

“…The antioxidative effi cacy of unripe banana peel has been shown effective in the prevention and treatment of peptic ulcers in rat model. It is interesting to know that the active agent in unripe bananas is water soluble and becomes inactive in ripe banana peel (Best et al, 1984). More research should be carried out to determine the complete profi les of phytochemicals, such as, phenolic acids, fl avonoids, phytoestrogens and carotenoids of bananas (pulp and peel) in relation to their antioxidant capacities or other bioactivities.…”

Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals

“…Studies on cabbage previously employed as an anti ulcer agent in folk medicine, has led to the development of gefarnate [2], which acts by enhancing the gastric mucosal strength [3]. Banana fruit was found to inhibit peptic ulceration [4]. Similarly large cardamom (Fruit of Amomum subulatum Roxb) and its ethyl acetate fraction seemed to exhibit protective effect on gastric mucosal barrier [5].…”

Evaluation of post-surgical healing in rats using a topical preparation based on extract of Musa sapientum L., Musaceae, epicarp

“…originates from Asia, but is widely grown in most countries, including Brazil (Jesus et al, 2004). The consumption of this fruit is great because of their nutritional value; its shell has been studied for treatment of gastrointestinal disorders (diarrhea, gastritis and gastric ulcers) (Best et al, 1984;Dadoo et al, 1995;Goel et al, 1986;Lewis et al, 1999;Pannangpetch et al, 2001) and commonly is used to treat wounds, especially in nipple fissures that arise during breastfeeding (Novak et al, 2003).…”