The anti-Zika virus and anti-tumoral activity of the citrus flavanone lipophilic naringenin-based compounds

Mendes, Larissa Albuquerque de Oliveira; Ponciano, Carolina Sousa; Cataneo, Allan Henrique Depieri; Wowk, Pryscilla Fanini; Bordignon, Juliano; Silva, Heveline; Almeida, Mauro Vieira de; Ávila, Eloah Pereira

doi:10.1016/j.cbi.2020.109218

Cited by 30 publications

(23 citation statements)

References 66 publications

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“…These effects have been associated with the capacity of polyphenols to exert anti-inflammatory and immunomodulatory effects (such as modulation of the expression of cytokines including IL-6, IL-8 and IFN-β) or capacity to modulate molecular pathways associated with viral infection (such as Toll-like receptor 7 signaling pathway, cell cycle pathway or autophagy related pathways). Several studies have also observed potential anti-Zika virus activity of polyphenols, such as the citrus flavanones [ 61 , 62 ], flavonoids [ 63 ] or quercetin-3-β- O -D-glucoside [ 64 ]. Antiviral activity against Ebola virus has been reported for several polyphenols, such as quercetin [ 65 ], quercetin 3-β- O -D-glucoside [ 66 ] or epigallocatechin-3-gallate [ 67 ].…”

Section: Antiviral Properties Of Polyphenolsmentioning

confidence: 99%

Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells

Milenković¹,

Ruskovska²,

Rodríguez-Mateos³

et al. 2021

Aging and disease

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Section: Antiviral Properties Of Polyphenolsmentioning

confidence: 99%

Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells

Milenković¹,

Ruskovska²,

Rodríguez-Mateos³

et al. 2021

Aging and disease

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“…However, the main handicap of naringenin is its low solubility and, therefore, low oral bioavailability. Nevertheless, the functionalization of the molecule with certain lipophilic groups may enhance its biochemical properties [100]. Furthermore, naringenin-glycosylated forms present in fermented orange juice increase this compound's absorption profile from the diet [75].…”

Section: Natural Compounds Against Staphylococcal Infectionsmentioning

confidence: 99%

Novel Treatments and Preventative Strategies Against Food-Poisoning Caused by Staphylococcal Species

et al. 2021

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Staphylococcal infections are a widespread cause of disease in humans. In particular, S. aureus is a major causative agent of infection in clinical medicine. In addition, these bacteria can produce a high number of staphylococcal enterotoxins (SE) that may cause food intoxications. Apart from S. aureus, many coagulase-negative Staphylococcus spp. could be the source of food contamination. Thus, there is an active research work focused on developing novel preventative interventions based on food supplements to reduce the impact of staphylococcal food poisoning. Interestingly, many plant-derived compounds, such as polyphenols, flavonoids, or terpenoids, show significant antimicrobial activity against staphylococci, and therefore these compounds could be crucial to reduce the incidence of food intoxication in humans. Here, we reviewed the most promising strategies developed to prevent staphylococcal food poisoning.

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“…Naringenin-derived mono-7-O-ether and mono-and di-fatty acid ester compounds were synthesized and tested in vitro for their anti-ZIKV activity. Lipophilic ether derivatives of naringenin presented anti-ZIKV activity but also showed higher cytotoxicity than unmodified NAR without any improvement in the selectivity index (Albuquerque de Oliveira Mendes et al, 2020).…”

Section: Structure: Activity Relationshipmentioning

confidence: 99%

Flavonoids as Molecules With Anti-Zika virus Activity

et al. 2021

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Zika virus (ZIKV) is an arthropod-born virus that is mainly transmitted to humans by mosquitoes of the genus Aedes spp. Since its first isolation in 1947, only a few human cases had been described until large outbreaks occurred on Yap Island (2007), French Polynesia (2013), and Brazil (2015). Most ZIKV-infected individuals are asymptomatic or present with a self-limiting disease and nonspecific symptoms such as fever, myalgia, and headache. However, in French Polynesia and Brazil, ZIKV outbreaks led to the diagnosis of congenital malformations and microcephaly in newborns and Guillain-Barré syndrome (GBS) in adults. These new clinical presentations raised concern from public health authorities and highlighted the need for anti-Zika treatments and vaccines to control the neurological damage caused by the virus. Despite many efforts in the search for an effective treatment, neither vaccines nor antiviral drugs have become available to control ZIKV infection and/or replication. Flavonoids, a class of natural compounds that are well-known for possessing several biological properties, have shown activity against different viruses. Additionally, the use of flavonoids in some countries as food supplements indicates that these molecules are nontoxic to humans. Thus, here, we summarize knowledge on the use of flavonoids as a source of anti-ZIKV molecules and discuss the gaps and challenges in this area before these compounds can be considered for further preclinical and clinical trials.

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The anti-Zika virus and anti-tumoral activity of the citrus flavanone lipophilic naringenin-based compounds

Cited by 30 publications

References 66 publications

Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells

Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells

Novel Treatments and Preventative Strategies Against Food-Poisoning Caused by Staphylococcal Species

Flavonoids as Molecules With Anti-Zika virus Activity

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