The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

Abstract

This Feature Article focuses on the antibacterial activity of POMs and POM-based hybrid and nanocomposite structures highlighting recent advances in the synthesis of biologically active POM systems and providing the state of the art in this research field.

Preparation of polyoxometalate-doped aminosilane-modified silicate hybrid as a new barrier of chem-bio toxicant

“…POMs exert significant biological activities, with high efficacy and low toxicity. With regards to the biological activity of the POMs, many literature reports describe the activity of polyoxometalates with Keggin, lacunary Keggin, Wells-Dawson, double-Keggin and Keggin-sandwich structures against methicillin-resistant Staphylococcus aureus (MRSA) [16], Helicobacter pylori [17], SARS coronavirus (SARS-CoV) [18] and Cancer [19]. With regards to the biological activity of the POMs, many literature reports describe the activity of polyoxometalates with Keggin, lacunary Keggin, Wells-Dawson, double-Keggin and Keggin-sandwich structures against methicillin-resistant Staphylococcus aureus (MRSA) [16], Helicobacter pylori [17], SARS coronavirus (SARS-CoV) [18] and Cancer [19].…”

Antibacterial Activity of Polyoxometalates Against Moraxella catarrhalis

“…Alongside with applications of POMs in catalysis (Wang and Yang, 2015), nanotechnology (Yamase and Pope, 2006), electrochemistry (Sadakane and Steckhan, 1998), material sciences (Proust et al, 2008), and molecular magnetism (Clemente-Juan et al, 2012), POMs have also been proven to exhibit remarkable biological activity. Due to the highly negative charge, strong acidity, geometry, their use in macromolecular crystallography (Bijelic and Rompel, 2015, 2017; Molitor et al, 2017) and as antimicrobial, (Yamase, 2005; Li et al, 2016; Bijelic et al, 2018), antiviral (Judd et al, 2001), antitumor (Fu et al, 2015), antidiabetes (Nomiya et al, 2001), and antiamyloid-fibril agents (related to Alzheimer's disease) (Gao et al, 2014) has been reported so far and more attention should be given to the biological and therapeutic effect of POMs.…”

“…In general POVs, especially decavanadate, and large, highly negatively charged POMs exhibit a high activity, whereas for example the activity of Keggin type POMs is bacterial strain dependent (Bijelic et al, 2018). …”

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends

“…The mechanisms of antibacterial activity of V, which have not been fully elucidated yet, include: (a) inhibition of the activity of Na + /K + -ATPase ( Fig. 11) [26,123,137,143], (b) generation of ROS ( Fig. 11), (c) impact on transport of substrates (e.g.…”

“…11) along with induction of potassium (K + ) outflow from the cell [137], (d) interaction with topoisomerase type II (gyrase) ( Fig. 11), which is necessary for the proper functioning of the genome and bacterial growth, with the ATP-binding site used as a target for antibacterial drugs [144,145], (e) interaction with DNA in an intercalative manner [133] resulting in modification of the DNA structure (unwinding, stiffening, and elongation of the double helix) with formation of an intercalative complex [146], (f) interaction with components of the cytoskeleton, which results in morphological alterations of bacterial cells thereby preventing proper division [137], and (g) other nonspecific mechanisms of action ( Fig. 11), with emphasis on the better bioavailability of V complexes due to the presence of a specific ligand allowing the complex to penetrate the hydrophobic lipid-rich bacteria wall [acc.…”