The antibacterial effect of water-soluble compounds from autoxidsing linolenic acid

Sensitivity of staphylococci to fatty acids: novel inactivation of linolenic acid by serum

“…About 60% of each of the end points were at the medians. Because linolenic acid decomposes in aqueous emulsions (Gutteridge, Lamport and Dormandy, 1976), some experiments were performed in which a 10% (v/v) emulsion of linolenic acid in physiological saline was incubated with agitation for 72 h at 37°C at 150 rpm before inclusion into nutrient agar. The antibacterial activity as judged by 18 test bacteria (see above) was the same as that for medium containing freshly incorporated linolenic acid.…”

Bacterial Inhibitors Formed During the Adventitious Growth of Micro‐organisms in Chicken Liver and Pig Kidney

“…Dialysis membrane did not impede the diffusion of these substances, indicating that they were of low molecular weight. This contrasted with the effect observed for lysozyme and similar high molecular weight inhibitory substances (Terplan et al 1973;Schmidt & Cremmling 1975;Forschner & Glende 1976;Forschner & Seidler 1976;Heinert et al 1976) which were released when tissues were thawed from the deep-frozen state. The particular t.1.c.…”

“…The polar component C gave an acid-spray reaction and its behaviour in another t.1.c. system resembled lactate, but the polar 'autoxidation' products of unsaturated fatty acids described by Gutteridge et al (1974Gutteridge et al ( , 1976 might also account for the activity of this component.…”

“…Although the inhibitory role of lysozyme and similar substances has been examined in this context, especially in pig kidneys (Terplan et al 1973;Schmidt & Cremmling 1975;Forschner & Glende 1976;Forschner & Seidler 1976;Heinert et al 1976), there appears to be little published information concerning other inhibitory factors in animal tissues which may also interfere with screening tests.…”

Detection by Fluorescence of Peroxides and Carbonyls in Samples of Arachidonic Acid

“…Lipid autoxidation is an autocatalytic process initiated and sustained by free radicals. During the process of lipid autoxidation numerous primary peroxidic and secondary carbonyl compounds are formed (Noble & Nawar, 1971: Gutteridge, Lamport & Dormandy, 1976. These molecules, derived in this way, are known to possess potent biological properties demonstrated by their antimicrobial, anti-cancer, platelet aggregating, blood coagulating and chemotactic effects (Schauenstein, 1967;Mickel & Horbar, 1974;Barrowcliffe, Gutteridge & Dormandy, 1975;Turner, Campbell & Lynn, 1975;Gutteridge et al, 1976).…”