The antibacterial properties of light-activated polydimethylsiloxane containing crystal violet

Ozkan, Ekrem; Allan, Elaine; Parkin, Ivan P.

doi:10.1039/c4ra08503e

Cited by 21 publications

(52 citation statements)

References 21 publications

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“…The triplet state dye molecules can undergo one of two photochemical pathways 44 ; quenching by molecular oxygen including the production of singlet oxygen ( 1 O2), or interaction with biomolecules in the vicinity generating radical species. The generated 1 O2 and radical species can initiate multi-site attack on bacteria in the vicinity effecting cell death 55 .…”

Section: Resultsmentioning

confidence: 99%

“…The antimicrobial activity of CV, TBO, and MB dyes is dependent on their concentration, the exposure time, and the intensity of the light source 52,53 . Recent studies from our group have investigated the application of CV, TBO, and MB dyes to polymers to generate antimicrobial surfaces for use in medical devices including tracheal or urinary catheters and tubes for intravenous drips 54,55 . We have shown that the dyes can be readily impregnated into polymers using a swell-encapsulation-shrink process, and the polymers showed potent photobactericidal activity in white light 44,55 .…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies from our group have investigated the application of CV, TBO, and MB dyes to polymers to generate antimicrobial surfaces for use in medical devices including tracheal or urinary catheters and tubes for intravenous drips 54,55 . We have shown that the dyes can be readily impregnated into polymers using a swell-encapsulation-shrink process, and the polymers showed potent photobactericidal activity in white light 44,55 . In addition, incorporation of gold (Au) nanoparticles into a dye impregnated polymer significantly enhanced the photobactericidal effect 54,56 .…”

Section: Introductionmentioning

confidence: 99%

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White Light-Activated Antimicrobial Paint using Crystal Violet

Hwang

Allan

Parkin

2015

ACS Appl. Mater. Interfaces

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Crystal violet (CV) was incorporated into acrylic latex to produce white light activated antimicrobial paint (WLAAP). Measurement of the water contact angle of the WLAAP showed that the water contact angle increased with increasing CV concentration. In a leaching test over 120 h, the amount of CV which leached from the WLAAPs was close to the detection limit (<0.03 %). The WLAAPs were used to coat samples of polyurethane and these showed bactericidal activity against E. coli which is a key causative agent of healthcare-associated infections (HAIs). A reduction in the numbers of viable bacteria was observed on the painted coated polyurethane after 6 h in the dark and the bactericidal activity increased with increasing CV concentration (P <0.1). After 6 h of white light exposure, all of coated polyurethanes demonstrated a potent photobactericidal activity and it was statistically confirmed that the WLAAP showed better activity in white light than in the dark (P <0.05). At the highest CV concentration, the numbers of viable bacteria fell below the detection limit (<10 3 CFU/mL) after 6h of white light exposure. The difference in antimicrobial activity between the materials in the light and dark was 0.48 log at CV 250 ppm and it increased by 0.43 log at each increment of CV 250 ppm. The difference was the highest (>1.8 log) at the highest CV concentration (1000 ppm).These WLAAPs are promising candidates for use in healthcare facilities to reduceHAIs.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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White Light-Activated Antimicrobial Paint using Crystal Violet

Hwang

Allan

Parkin

2015

ACS Appl. Mater. Interfaces

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“…This methodw as used by Perni et al [43] to incorporate methylene blue/AuNPs into silicone. Later,O zkan et al [44] developed light-activated PDMSt hat contained crystal violet (12)a nd methylene blue (13). These two substances belong to the family of so-called light-activateda ntimicrobial agents( LAAAs).…”

Section: Swell-encapsulation Methodsmentioning

confidence: 99%

Recent Developments in the Preparation of Silicones with Antimicrobial Properties

Kottmann

Mejía

Hémery

et al. 2017

Chemistry An Asian Journal

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This Focus Review describes state-of-the-art methods for the preparation of antimicrobials ilicones. Given the diversity of antimicrobiala ctivity and their mechanisms, the performance of these materials is highly dependento nt he characteristics of the polymeric matrix. Therefore, different synthetic routes have been developed, such as 1) physical treatments,2 )chemical transformations, and 3) copolymerization. This classification is not exclusive,s os ome products belong to more than one class. Herein, we attemptt op resent ah andy overview of the development of antimicrobial silicones, their most important application fields, the most relevant antimicrobiala ssays,a nd, as the title suggests, an overview of the most relevant preparation methods.

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“…7 Our research group has developed new ways to potentially reduce HAIs associated with medical devices, by developing new polymeric materials that can be used as catheter materials and to coat hospital surfaces. [8][9][10][11][12][13][14][15][16][17] Such materials include silicone rubber, 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 polyvinylchloride, polyurethane and polypropylene. 18 These materials can also be used to treat HAIs caused by commonly touched surfaces in hospital wards (e.g.…”

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confidence: 99%

Potent Antibacterial Activity of Copper Embedded into Silicone and Polyurethane

Sehmi

Noimark

Weiner

et al. 2015

ACS Appl. Mater. Interfaces

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A simple, easily up-scalable swell-encapsulation-shrink technique was used to incorporate small 2.5 nm copper nanoparticles (CuNPs) into two widely used medical grade polymers, polyurethane, and silicone, with no significant impact on polymer coloration. Both medical grade polymers with incorporated CuNPs demonstrated potent antimicrobial activity against the clinically relevant bacteria, methicillin-resistant Staphylococcus aureus and Escherichia coli. CuNP-incorporated silicone samples displayed potent antibacterial activity against both bacteria within 6 h. CuNP-incorporated polyurethane exhibited more efficacious antimicrobial activity, resulting in a 99.9% reduction in the numbers of both bacteria within just 2 h. With the high prevalence of hospital-acquired infections, the use of antimicrobial materials such as these CuNP-incorporated polymers could contribute to reducing microbial contamination associated with frequently touched surfaces in and around hospital wards (e.g., bed rails, overbed tables, push plates, etc.).

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The antibacterial properties of light-activated polydimethylsiloxane containing crystal violet

Abstract: Crystal violet was incorporated into polydimethylsiloxane (PDMS) by a swell–encapsulation–shrink method using chloroform as a swelling solvent.

Cited by 21 publications

References 21 publications

White Light-Activated Antimicrobial Paint using Crystal Violet

White Light-Activated Antimicrobial Paint using Crystal Violet

Recent Developments in the Preparation of Silicones with Antimicrobial Properties

Potent Antibacterial Activity of Copper Embedded into Silicone and Polyurethane

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