The Antibody Response of Guinea Pigs to Topical and Intramuscular Administration of Trachoma Antigens

Zakay‐Rones, Zichria; Levi, R; Maythar, B.; Becker, Yechiel

doi:10.4049/jimmunol.102.5.1290

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extent of the secretory immunc response elicited dcpends on the route of immunization. In order to evoke a local response, antigen should be applied to the site [16,18,19,21]. The parenteral route of immunization leads to humoral immunity only.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the lung local immune response by systemic immunization

Zakay‐Rones

Hadas

Levy

1978

Med Microbiol Immunol

View full text Add to dashboard Cite

The present study describes the respiratory immune response of mice to locally administered antigen, and the modulation of this response by systemic immunization. Intranasal immunization of mice with the A/PR/8/34 strain of influenza virus evoked local antibody response of the IgA type. The titer of the IgA antibodies declined to a nondetectable level in 40--50 days. If at that time a second intranasal dose was administered, a secondary IgA response was evoked. On the other hand, administration by the intramuscular route resulted in a mixed population of IgA and IgG antibodies. The relevance of this finding to problems of immunization against respiratory viral infections is discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulation of the lung local immune response by systemic immunization

Zakay‐Rones

Hadas

Levy

1978

Med Microbiol Immunol

View full text Add to dashboard Cite

show abstract

Local and peripheral cell‐mediated immune response to influenza virus in mice

Shapira‐Nahor¹,

Zakay-Rones²

1985

Journal of Medical Virology

View full text Add to dashboard Cite

Presentation of different influenza virus antigens generates different immune responses. Intranasal immunization with either live (VA) or formalin-inactivated (VF) A/PR/8/34 (HON1) influenza virus induced local as well as peripheral cell-mediated immune response (CMI), as evidenced by elevation in 3H-thymidine incorporation. Cell-mediated immune response was detected as soon as 24-48 hr following the application of VA and 4-5 days following VF. Cell-mediated immune response in both instances peaked on the 12th day and disappeared between 16 and 20 days after application. Local CMI response was threefold higher after immunization with VA (SI = 28.6) than with VF (SI = 9.4), while VF induced higher peripheral response (32.0 vs 17.7). The mononuclear cell population in the lungs increased, correlating with a rise in the stimulation index (SI). The percentage of IgA surface-bearing B lymphocytes was significantly higher following IN administration of VA, but not following VF instillation. This corroborated the finding that VF failed to induce local antibody response in the lungs in spite of its capacity to stimulate humoral antibody and CMI responses. Mice immunized intramuscularly with both viral preparations developed a fair humoral antibody response without detectable CMI (peripheral or local).

show abstract