The anticancer activities of Vernonia amygdalina Delile. Leaves on 4T1 breast cancer cells through phosphoinositide 3-kinase (PI3K) pathway

Hasibuan, Poppy Anjelisa Zaitun; Harahap, Urip; Sitorus, Panal; Satria, Denny

doi:10.1016/j.heliyon.2020.e04449

Cited by 45 publications

(31 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of them are new compounds and this will be very useful for drug development [25]. Secondary metabolites, when taken as a single component or in combination, can be effective and safe even when synthetic medications fail [26]. They may potentially enhance or synergize the effects of other pharmaceutical ingredients [27] for further discussion will be discussed the relationship of secondary metabolites and their pharmacological activity in L. domesticum Corr.…”

Section: Natural Product Identification Of L Domesticum Corrmentioning

confidence: 99%

A Review on Phytochemicals and Pharmacological Activities as Ethnomedicinal Uses of Duku (Lansium domesticum Corr.)

Lubis

Hasibuan

Syahputra

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Lansium domesticum Corr. is a plant that is easily found in Indonesia. People use the fruit to be sold because it has a good taste. Some people use other parts of the plant as medicine. This plant has great potential to be developed as a standardized traditional medicine. AIM: This article review aims to collect information on secondary metabolite compounds from L. domesticum Corr. and its pharmacological activities as antioxidants, antibacterials, and cytotoxics. METHODS: Data on L. domesticum Corr. or duku were sought and collected for this miniature estimate and perspective. We use the major search engines with specific keywords such as L. domesticum Corr.; duku; morphology; pharmacological effects; secondary metabolites; in vitro; and in vivo. RESULTS: This review shows that L. domesticum Corr. have antioxidant, antibacterial, and cytotoxic activity of various compounds based on the test method used. CONCLUSIONS: Some parts of L. domesticum Corr. such as leaves, fruit, fruit skins, and seeds contain secondary metabolite compounds. The most common type of active compound is the steroid/terpenoid group. These compounds are responsible for their pharmacological activities such as antioxidants, antibacterials, and cytotoxics.

show abstract

Section: Natural Product Identification Of L Domesticum Corrmentioning

confidence: 99%

A Review on Phytochemicals and Pharmacological Activities as Ethnomedicinal Uses of Duku (Lansium domesticum Corr.)

Lubis

Hasibuan

Syahputra

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…An antidiabetic effect of VA was reported by Erukainure et al [ 13 ], while Okunlola et al [ 14 ] gave a report of its antioxidant properties. Additionally, its anticancer property has been reported [ 15 ]. Some bioactive constituents have been identified in the leaves of the plant, including steroid glycosides like vernonioside A1, A2, A3 [ 16 ] and vernonioside B2, B3, B4 [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Vernonia amygdalina (Astereaceae) Extract on CCl4-Induced Liver Injury in Broiler Chickens

Tokofai

Idoh

Oke

et al. 2021

Animals

View full text Add to dashboard Cite

The aim of this study was to evaluate the effect of Vernonia amygdalina leaf extract (VALE) on the carbon tetrachloride-induced hepatotoxicity (CCl4) in broiler chickens. A total of 360-day-old broilers were divided into 4 treatments of 90 birds each consisting of 6 replicates of 15 birds each. The treatments were birds offered 1 mL/kg BW saline (control group), 100 mg/kg BW VALE, 1 mL/kg BW CCl4 (CCl4-treated group), and 100 mg/kg BW VALE + 1 mL/kg BW CCl4 (VALE + CCl4 group). Blood samples were collected at 42 days of age and analyzed for the liver enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and selected biochemical parameters. The experiment was laid out in a completely randomized design. The results obtained showed that VALE had the potential to mitigate the adverse effects of CCl4 on protein and lipid metabolism as reflected in the low serum malondialdehyde (MDA) levels, which is a marker of lipid peroxidation. The aqueous extract of Vernonia amygdalina (VA) at a dose of 100 mg/kg body weight showed a moderate hepatoprotective effect by reducing serum AST levels (p < 0.05). The levels of serum AST, ALP, ALT, and GGT were significantly increased in CCl4-treated birds compared to the control group, reflecting carbon tetrachloride-induced liver damage. The VALE + CCl4 group showed a significantly higher amount of ALP compared to birds treated with carbon tetrachloride, suggesting a hepatoprotective effect. To conclude, Vernonia amygdalina aqueous extract can be used to confer protection against hepatotoxicity, which can induce severe hepatocellular damage in birds.

show abstract

“…The presence of polyphenols, vitamins and mineral salts make the plant useful in human diets [25,26]. V. amygdalina is very rich in phytochemicals such as saponins, sesquiterpenes, flavonoids, and steroid glycosides (vernosides), lactones [26] and several studies reported that it has anticancer and antitumor activity [27,28]; antihepatotoxic activity [29]; hypoglycemic activity [26]; antibacterial activity [30]; anti-inflammatory [31] as well as antioxidant property [32].…”

mentioning

confidence: 99%

Galleria mellonella as a novel eco-friendly in vivo approach for the assessment of the toxicity of medicinal plants

Arsène¹,

Pi²,

Ak³

2021

Preprint

View full text Add to dashboard Cite

The evaluation of medicinal plants toxicity is a prerequisite prior their usage. The vertebrate models used for this purpose are often the object of ethical consideration. Though invertebrate models including Galleria mellonella have shown their ability to be used to assess various products toxicity, to our knowledge, G. mellonella has never been exploited to determine the toxicity of medicinal plants. In this study, the toxicity of hydroalcoholic and aqueous extracts of seven (7) Cameroonian medicinal plants namely leaves of Cymbopogon citratus (DC.) Stapf, Moringa oleifera Lam and Vernonia amygdalina Delile; barks of Cinchona officinalis and Enantia chloranta Oliv; barks and seeds of Garcinia lucida Vesque and leaves and seeds of Azadirachta indica (Neem) were evaluated using the larval form of the Greater Wax Moth (Galleria mellonella). The median lethal doses (LD50), 90% lethal doses (LD90) and 100% lethal doses were successfully determined using the spline cubic survival curves and equations from the data obtained on the survival rate of G. mellonella 24h after the injection with the extracts. The LD50 values varied from 3.90 g/kg bw to >166.67 g/kg bw and the pattern of toxicity observed was in accordance with previous investigations on the plant materials concerned. The results obtained in this study suggest that G. mellonella can be used as a sensitive, reliable, and robust eco-friendly model to gauge the toxicity of medicinal plants. Thus, avoid the sacrifice of vertebrate models often used for this purpose to limit ethical concerns.

show abstract

The anticancer activities of Vernonia amygdalina Delile. Leaves on 4T1 breast cancer cells through phosphoinositide 3-kinase (PI3K) pathway

Cited by 45 publications

References 41 publications

A Review on Phytochemicals and Pharmacological Activities as Ethnomedicinal Uses of Duku (Lansium domesticum Corr.)

A Review on Phytochemicals and Pharmacological Activities as Ethnomedicinal Uses of Duku (Lansium domesticum Corr.)

Hepatoprotective Effects of Vernonia amygdalina (Astereaceae) Extract on CCl4-Induced Liver Injury in Broiler Chickens

Galleria mellonella as a novel eco-friendly in vivo approach for the assessment of the toxicity of medicinal plants

Contact Info

Product

Resources

About