The Anticancer Effects of Resveratrol: Modulation of Transcription Factors

Whitlock, Nichelle C.; Baek, Seung Joon

doi:10.1080/01635581.2012.667862

Cited by 126 publications

(86 citation statements)

References 87 publications

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“…Previous studies have reported that resveratrol exerted antitumor activities at various stages of tumor initiation, promotion and progression (Cimino et al, 2012;Stefanska et al, 2012;Whitlock et al, 2012), including in esophageal squamous cell carcinoma (Tang et al, 2013). However, the molecular mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling

Guanghua

Wang²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Resveratrol has been examined in several model systems for potential effects against cancer. Adenosine monophosphate-activated protein kinase (AMPK) is reported to suppress proliferation in most eukaryocyte cells. Whether resveratrol via AMPK inhibits proliferation of oesophageal adenocarcinoma cells (OAC) is unknown. The aim of this study was to determine the roles of AMPK in the protective effects of resveratrol in OAC proliferation and to elucidate the underlying mechanisms. Treatment of cultured OAC derived from human subjects or cell lines with resveratrol resulted in decreased cell proliferation. Further, inhibition of AMPK by pharmacological reagent or genetical approach abolished resveratrol-suppressed OAC proliferation, reduced the level of p27 Kip1 , a cyclin-dependent kinase inhibitor, and increased the levels of S-phase kinase-associated protein 2 (Skp2) of p27 Kip1 -E3 ubiquitin ligase and 26S proteasome activity reduced by resveratrol. Furthermore, gene silencing of p27 Kip1 reversed resveratrol-suppressed OAC proliferation. In conclusion, these findings indicate that resveratrol inhibits Skp2-mediated ubiquitylation and 26S proteasome-dependent degradation of p27 Kip1 via AMPK activation to suppress OAC proliferation.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling

Guanghua

Wang²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

“…One well-known example of the stilbenes is resveratrol, and its antitumor activity has been intensively studied. Several in vivo and in vitro studies have shown that resveratrol inhibits the growth of cancer cells and effects various molecular targets associated with cancer progression such as the Wnt signaling pathway, nuclear factor-kappa B (NF-κB), and the MAPK/ERK pathway in different types of cancer (17,18).Previously, two novel stilbenes, cis-and trans-suffruticosol D, were extracted from the seeds of Paeonia (5). The two chemicals have similar structures as the mass fragmentation pattern of trans-suffruticosol D was very similar to cis-suffruticosol D, with cis-suffruticosol D varying only from trans-suffruticosol D in its olefinic hydrogen signal (Fig.…”

mentioning

confidence: 99%

In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D, isolated from Paeonia suffruticosa seeds

Almosnid

Gao

et al. 2015

International Journal of Oncology

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Abstract. Naturally derived stilbenes have been shown to elicit cytotoxic, anti-steroidal, anti-mutagenic, anti-oxidative, anti-inflammatory, and antitumor bioactivities. Previous phytochemical studies revealed that the seeds of Paeonia suffruticosa are rich in natural stilbenes. In this study the antitumor effects and mechanism of action of the oligostilbene isomers, cis-and trans-suffruticosol D, isolated from the seeds of P. suffruticosa were examined. cis-and transsuffruticosol D exhibited remarkable cytotoxicity against the human cancer cell lines A549 (lung), BT20 (breast), MCF-7 (breast), and U2OS (osteosarcoma), but showed significantly less toxicity to the normal human cell lines HMEC (breast) and HPL1A (lung). We also demonstrated that cis-and transsuffruticosol D exerted their antitumor effects by provoking oxidative stress, stimulating apoptosis, decreasing the mitochondrial membrane potential, inhibiting cell motility, and blocking the NF-κB pathway in human lung cancer cells. In addition, we evaluated their respective bioefficacy and found that trans-suffruticosol D is more potent than cissuffruticosol D. Collectively, our results suggest that cis-and trans-suffruticosol D could be promising chemotherapeutic agents against cancer. IntroductionCurrent cancer medications are costly and often cause serious side effects. The US National Cancer Institute began investigating antitumor plant extracts in the 1960s, and the premise that natural compounds obtained from therapeutic plants could produce anticancer medications has henceforth been of great research interest. Traditional Chinese medicines (TCMs) using dried plants or plant extracts have provided low cost diet and pharmaceutical therapies for thousands of years and experimental and clinical studies have proven that >400 plant species used in TCMs as anticancer herbal medications are significantly effective in the prevention or treatment of various cancers (1-4). However, much work remains to be done to determine the effectiveness of the individual compounds present in the TCMs.Paeonia suffruticosa, or Paeoniaceae, is a widely utilized Chinese medicinal plant within the Paeonia genus. This genus comprises ~35 species that are classified into three groups: Oneapia, Paeonia, and Moutan (5). The Cortex Moutan (root cortex) of Paeonia has been recorded by China's Pharmacopoeia as a significant source of herbal medicine (6). Extracts of Paeonia have been shown to possess cytotoxic, antitumor, anti-inflammatory and anti-oxidative activities (5). Previous photochemical research on Paeonia identified >260 bioactive compounds, including phenols, monoterpenoidglucosides, paeonols, flavonoids, tannins, steroids, triterpenoids and stilbenes (7). A more recent study showed that the seeds of Paeonia contain considerable quantities of stilbenes compared to the other compounds (7,8).Stilbenes are a class of polyphenols widely found in plants that contain a 1.2-diphenylethylene nucleus in their structure (9). Stilbenes have aroused great interest due to their antit...

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“…Many studies have suggested that RES suppresses the growth of many cancer cells through multiple, intricate cellular signaling pathways, such as the STAT, NF-κB and Wnt signaling pathways (Vang et al 2011;Aluyen et al 2012;Whitlock & Baek 2012). Some studies also reported that RES inhibits the EMT process in pancreatic cancer cells by inhibiting the PI-3 K/Akt pathway (Li et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway

Zhi

Tong

et al. 2016

Animal Cells and Systems

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Resveratrol possesses a wide spectrum of pharmacological properties and has been an ideal alternative drug for the treatment of different cancers, including prostate cancer. However, the mechanisms by which resveratrol inhibits the growth of prostate cancer are still not fully elucidated. To understand the effect of resveratrol on the apoptosis and the epithelial-tomesenchymal transition (EMT) of prostate cancer as well as its related mechanism, we investigated the potential use of resveratrol in PC-3 prostate cancer cells in vitro using real-time PCR, fluorescence-activated cell sorting, Western blotting, etc. Resveratrol suppresses the PC-3 prostate cancer cell growth and induces apoptosis. Resveratrol also influences the expression of EMT-related proteins (increased E-cadherin and decreased Vimentin expression). Finally, resveratrol also suppressed Akt phosphorylation in PC-3 cells. This study indicates that resveratrol may be a potential anti-cancer treatment for prostate cancer; moreover, it provides new evidence that resveratrol suppresses prostate cancer growth and metastasis.ARTICLE HISTORY

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The Anticancer Effects of Resveratrol: Modulation of Transcription Factors

Cited by 126 publications

References 87 publications

Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling

Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling

In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D, isolated from Paeonia suffruticosa seeds

Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway

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