The Anticandidal and Toxicity Properties of <i>Lampranthus francisci</i>

Moyo, Batanai; Mukanganyama, Stanley

doi:10.1155/2015/898202

Cited by 7 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…e ethanol:water extract was the most potent against all 4 test strains. High potency of the hydroethanolic extracts has been reported elsewhere against Candida [30] and bacteria [31]. Maximal activity of the ethanol:water extract was observed against S. epidermidis with total inhibition at 100 μg/mL of the extract.…”

Section: Discussionsupporting

confidence: 52%

Antibacterial, Antifungal, and Antidiabetic Effects of Leaf Extracts from Persea americana Mill. (Lauraceae)

Makopa

Mangiza

Banda

et al. 2020

Biochemistry Research International

Self Cite

View full text Add to dashboard Cite

Fruits and leaves of Persia americana are used in traditional medical practices. This study was carried out to determine the antibacterial, antifungal, and antidiabetic effects of the leaf extracts from P. americana. The antibacterial activities of the leaf extracts were evaluated against Klebsiella pneumoniae and Staphylococcus epidermidis while antifungal activities were determined against Candida albicans and Candida tropicalis. The antidiabetic potential of the extracts was determined against mammalian α-glucosidase in vitro. The broth microdilution method was used to investigate the antibacterial and antifungal susceptibility of the microbial strains towards the leaf extracts. S. epidermidis was the most susceptible microbe out of the tested microorganisms. The acetone extract was the most potent extract against S. epidermidis with a minimum inhibitory concentration (MIC) of 50 μg/mL. At 100 μg/mL, the ethanol:water extract 18% of K. pneumoniae cells remained viable. Cell viability after exposure to the dichloromethane (DCM) and methanol extracts was 28% against C. albicans and 8% against C. tropicalis, respectively. The DCM:methanol and acetone extracts caused membrane damage in S. epidermidis exhibited by protein leakage. Only the acetone extract effected nucleic acid leakage. Screening of extracts’ potential to inhibit the activity of α-glucosidase was carried out spectrophotometrically following the production of p-nitrophenol from p-nitrophenol-glucopyranoside (substrate) at a wavelength of 405 nm. Out of all the tested extracts, the methanolic extract showed the best inhibitory activity on α-glucosidase enzyme in a time-dependent and dose-dependent manner. K i and K inact values were found to be 1.4 mg/mL and 2.4 U/min, respectively, after incubation for 1 hour. It was concluded that the leaf extracts of P. americana contain phytochemicals with antibacterial, antifungal, and α-glucosidase inhibitory effects. Further studies are required for the identification of the active compounds in the leaf extracts responsible for these observed effects.

show abstract

Section: Discussionsupporting

confidence: 52%

Antibacterial, Antifungal, and Antidiabetic Effects of Leaf Extracts from Persea americana Mill. (Lauraceae)

Makopa

Mangiza

Banda

et al. 2020

Biochemistry Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been also reported that genus Mesembryanthemum has long been used as food and in traditional medicine for the treatment of liver diseases and diabetes . The species Lampranthus francisci showed strong anticandidal activity . Moreover, studies showed that Lampranthus spectabilis has high phenolic content and displays strong antioxidant activity .…”

Section: Introductionmentioning

confidence: 97%

Cytotoxic Potential of Green Synthesized Silver Nanoparticles of Lampranthus coccineus Extracts, Metabolic Profiling and Molecular Docking Study

et al. 2020

View full text Add to dashboard Cite

The green synthesis of silver nanoparticles (SNPs) using plant extracts has gained great attention due to its unique properties. So, in this study, the aqueous and n-hexane extracts of Lampranthus coccineus F. Aizoaceae were used for the synthesis of silver nanoparticles. The early signs of SNPs synthesis were detected by a color change from yellow to reddish-brown color. The formation of SNPs was further confirmed using a transmission electron microscope (TEM), UV-Visible spectroscopy, and zeta potential. The TEM analysis of SNPs showed spherical nanoparticles with mean size ranges between 8.55 nm to 16.44 nm for Lampranthus coccineus aqueous and hexane extracts. The UV-Visible spectrophotometric analysis showed an absorption peak at λ max of 417 nm, which confirms the formation of SNPs. Zeta potential results indicated that the particles are negatively charged and fairly stable due to the electrostatic repulsion. The cytotoxic activity of the green synthesized SNPs as well as the four isolated compounds (β-Sitosterol-3-O-β-D-glucoside, P-methoxy benzoic acid, dibutyl phthalate, and dioctyl phthalate) was evaluated using MTT assay against MCF-7, HepG-2, and HCT-116 cell lines. Metabolic profiling of the annotated twelve compounds from the crude extract of L. coccineus. These compounds, along with the four isolated compounds were subjected to molecular docking study.

show abstract

“…L. francisci is an ornamental succulent plant. The hydro-alcohol extracts of L. francisci caused hemolysis of sheep cells and had a fungicidal activity (Moyo and Mukanganyama, 2015).…”

Section: Introductionmentioning

confidence: 99%

Total Phenol, Antioxidant and Allelopathy Assay, and Meiosis Study of Lampranthus spectabilis and Aptenia cordifolia

Hashemloian

Azimi

Rezakanlou

2019

Not Bot Horti Agrobo

View full text Add to dashboard Cite

Lamperanthus spectabilis and Aptenia cordifolia (Aiozaceae) are two ornamental plants. A little information is available about their active compounds and meiosis’ process. In this study, the phenolic content, antioxidant activity, allelopathy effects and meiosis’ process of pollen mother cells of L. spectabilis and A. cordifolia were studied. The alcohol extract was used for phenol, antioxidant and allelopathy assay along with young buds for meiosis study. The stamens and petals of both plants possessed the highest phenol and antioxidant effects. All extracts of L. spectabilis and A. cordifolia had small inhibitory effects on mungbeen seed germination and seedlings growth. The allelopathy effect of both plants on barley seed germination and seedlings growth was significant especially for A. cordifolia. The count of chromosomes in meiosis revealed that the chromosome number of A. cordifolia was 2n=12 and 2n=18 for L. spetabilis. The meiosis in both plants was normal and the chromosomes were very small. Our results revealed that the extracts of all organs of both plants; specially stamens and petals, have a lot antioxidant activity. They had not allelopathic effects on seed germination’ and seedlings growth’ mungbeen and barley. Chromosome number of two plants was different but meiosis process and chromosomes size was similar. ********* In press - Online First. Article has been peer reviewed, accepted for publication and published online without pagination. It will receive pagination when the issue will be ready for publishing as a complete number (Volume 47, Issue 4, 2019). The article is searchable and citable by Digital Object Identifier (DOI). DOI link will become active after the article will be included in the complete issue. *********

show abstract

The Anticandidal and Toxicity Properties of Lampranthus francisci

Cited by 7 publications

References 40 publications

Antibacterial, Antifungal, and Antidiabetic Effects of Leaf Extracts from Persea americana Mill. (Lauraceae)

Antibacterial, Antifungal, and Antidiabetic Effects of Leaf Extracts from Persea americana Mill. (Lauraceae)

Cytotoxic Potential of Green Synthesized Silver Nanoparticles of Lampranthus coccineus Extracts, Metabolic Profiling and Molecular Docking Study

Total Phenol, Antioxidant and Allelopathy Assay, and Meiosis Study of Lampranthus spectabilis and Aptenia cordifolia

Contact Info

Product

Resources

About