The Anticoagulant Effects in Rabbits and Man of the Intravenous Injection of Salts of the Rare Earths

Beaser, Samuel B.; Segel, Arnold; Vandam, Leroy D.

doi:10.1172/jci101321

Cited by 33 publications

(7 citation statements)

References 13 publications

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“…Lu was reported to be accumulated in the bones (much), liver, and kidneys, although there was no information for the biological effects. Holmium (Ho) and thulium (Tm) compounds are known to stimulate the metabolism of the human body, but their biological effects are still controversial [12], [29], [43]. Dermal fibrosis (nephrogenic systemic fibrosis) was reported by gadolinium (Gd) used as contrast agents for magnetic resonance images [44].…”

Section: Resultsmentioning

confidence: 99%

Worker Safety in the Rare Earth Elements Recycling Process From the Review of Toxicity and Issues

Shin

Kim

Rim

2019

Safety and Health at Work

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Although the rare earth elements (REEs) recycling industry is expected to increase worldwide in high-tech industry, regulations for worker safety have yet to be established. This study was conducted to understand the potential hazard/risk of REE recycling and to support the establishment of regulations or standards. We review the extensive literature on the toxicology, occupational safety, and health issues, and epidemiological surveys related to the REEs, and propose suitable management measures. REE recycling has four key steps such as collection, dismantling, separation, and processing. In these processes, hazardous substances, such as REEs-containing dust, metals, and chemicals, were used or occurred, including the risk of ignition and explosion, and the workers can be easily exposed to them. In addition, skin irritation and toxicities for respiratory, nervous, and cardiovascular systems with the liver toxicity were reported; however, more supplementary data are needed, owing to incompleteness. Therefore, monitoring systems concerning health, environmental impacts, and safety need to be established, based on additional research studies. It is also necessary to develop innovative and environment-friendly recycling technologies, analytical methods, and biomarkers with government support. Through these efforts, the occupational safety and health status will be improved, along with the establishment of advanced REE recycling industry.

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Section: Resultsmentioning

confidence: 99%

Worker Safety in the Rare Earth Elements Recycling Process From the Review of Toxicity and Issues

Shin

Kim

Rim

2019

Safety and Health at Work

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“…The rare earth metals have a retarding effect on blood coagulation (Steidle 1935, Vincke & Oelkers 1937, Beaser et al 1942, Hara & Sat0 1955. This property of the lanthanons led to exploration for a non-toxic lanthanon compound which could be utilized as an anti-thrombotic agent (Vincke 1955).…”

Section: A ) Il'ithin Industrymentioning

confidence: 99%

The Behavior of Certain Lanthanons in Rats

Magnusson¹

1963

Acta Pharmacologica et Toxicologica

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“…First described in the early 1930s [12], in 1937 Vincke and Oelkers reported another until then rather unknown property of rare earth metals, the anticoagulant potential, without being able to further clarify their mode of action [33]. At that time different rare earths were even proposed for use as therapeutic anticoagulation agents [7,33], which was later revised as inexpedient because of unwelcome side effects [1]. GdCl 3 is suggested to exert its anticoagulatory action by interfering in the generation of thrombin from prothrombin by factor Xa and by disturbing the proteolytic activation of factor XIII [11].…”

Section: Discussionmentioning

confidence: 99%

Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival

Rüttinger

Vollmar

Kempter

et al. 1998

Langenbeck's Archives of Surgery

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These results confirm reports on the protective potential of GdCl3 pretreatment in experimental endotoxemia. However, the present study does not support the concept of DIC as a strong prognostic criterion for the outcome of sepsis and septic shock. Furthermore, the results presented suggest a minor role for KC in LPS-mediated activation of coagulation and indicate an involvement of KC in LPS-associated lethality independent of the coagulation system.

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The Anticoagulant Effects in Rabbits and Man of the Intravenous Injection of Salts of the Rare Earths

Cited by 33 publications

References 13 publications

Worker Safety in the Rare Earth Elements Recycling Process From the Review of Toxicity and Issues

Worker Safety in the Rare Earth Elements Recycling Process From the Review of Toxicity and Issues

The Behavior of Certain Lanthanons in Rats

Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival

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