The Behavior of Certain Lanthanons in Rats

Magnusson, Göran

doi:10.1111/j.1600-0773.1963.tb02990.x

Cited by 57 publications

(13 citation statements)

References 63 publications

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“…The focal hepatic necroses in the rats probably do not represent a direct toxic effect. Focal necroses, as observed in this study, are considered to be due to an insufficient nutrition of the liver cells on account of a low blood pressure and reduced circulation ( Himsworth 1948, Magnusson 1963. Similar conditions may have occurred in the present investigation.…”

Section: Discussionsupporting

confidence: 81%

Hepatic Changes in Dogs and Rats Induced by Xylidine Isomers

Magnusson

Bodin

Hansson

1971

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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The effect of the xylidine isomers 2,4-, 2,5-, and 2,6-xylidine 011 the liver and kidneys of dogs and rats was studied. The dogs received oral doses of 2, 10, and 50 mg/kg and the rats 20, 100, and 500--700 mg/kg daily for 4 weeks. The xylidine isomers affected the liver but produced different hepatic changes in the dog and the rat. In the dog all 3 isomers induced a fatty degeneration of the liver. In the rat the 3 isomers caused a hepatomegaly mostly with a normal appearance of the liver cells. The enlargement of the liver was greatest for the 2,4-isomer and least for the 2,fi-isomer. No renal lesions were found in any of the doqs or rats a t any dose level.Received 6.iv.71 Requests for reprints should be addressed to Goran Magnusson Toxicology Laboratories, AB Astra, 151 85 Sodertalje, Sweden.

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Section: Discussionsupporting

confidence: 81%

Hepatic Changes in Dogs and Rats Induced by Xylidine Isomers

Magnusson

Bodin

Hansson

1971

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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“…Previous studies have demonstrated that the liver damage caused by a single intravenous injection of cerium is manifested by the production of fatty liver (SNYDER & STEPHENS 1961), morphological changes both in the liver mitochondria (GLENN et al 1962) and endoplasmic reticulum (MAGNUSSON 1963) and by an inhibitory effect on liver microsomal drug metabolizing enzymes (ARVELA & K~I 1971). The acute liver damage produced by the rare earth metals may also be responsible for the insufficient glycogen formation which in its turn causes hypoglycaemia (MAGNUSSON 1963). Pretreatment which drugs which are known to stimulate the micro-soma1 drug metabolizing enzymes has shown that they are of therapeutic value against various toxic substances both in newborn infants (TROLLE 1968; YAFFE et al 1966 we have investigated whether pretreatment with phenobarbital (phenemalum NFN) which is a proved and commonly used inducing substance, has any effect on the cerium (2 mg/kg) induced impairment of the drug metabolizing system in rats.…”

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confidence: 99%

The Effect of Phenobarbital Pretreatment on the Cerium Induced Impairment of Drug Metabolism in Rat

Arvela¹,

Kärki²

1972

Acta Pharmacologica et Toxicologica

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A bsfracf: The effect of phenobarbital pretreatment has been studied on cerium induced impairment of drug metabolism in rat liver. Male rats were divided into four groups: (1) controls, (2) receiving cerium intravenously 2 mg/kg, (3) pretreated with phenobarbital and (4) receiving the same amount of cerium as in group 2 after pretreatment with phenobarbital as in group 3. The pretreatment had a clear protective effect both against the cerium induced impairment of oxidative drug metabolism and the elevation of some enzyme activities. The pretreatment also normalized the decrease in blood glucose and the increase in plasma free fatty acids caused by cerium.

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“…Lanthanum is used profoundly in research, industry and medicine 4,5 , it is found desirable to study the effects of Lanthanum chloride exposure on the fertility of male mice.…”

Section: Introductionmentioning

confidence: 99%

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2013

IJPSR

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Fertility was tested in 0.5 mM/kg b. wt. (i.p) Lanthanum chloride exposed mice. Beneficial effects of "Fortege" an ayurvedic medicine (Alarsin co. Bombay) were also tested. Lanthanum chloride affected sperm count and motility. Lanthanum chloride could have affected Sertoli cells adversely and that have reduced sperm's ability of uptake of fructose and as a result of it sperms became unable to reach ovum and thus antifertility was shown. Maximum effects of Lanthanum chloride were on the weight of seminal vesicles and their fructose content. When such mice were exposed to "fortege" for 21 days and the efficacy obtained, was 87.5%. Only way to overcome Lanthanum toxicity is to remove Lanthanum from the tissues. For the removal of Lanthanum from the body tissues, the chelating activity of some alkaloids of these plants can be considered as the one of the main reason and it is supplemented by improvement in testosterone and LH level.

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The Behavior of Certain Lanthanons in Rats

Cited by 57 publications

References 63 publications

Hepatic Changes in Dogs and Rats Induced by Xylidine Isomers

Hepatic Changes in Dogs and Rats Induced by Xylidine Isomers

The Effect of Phenobarbital Pretreatment on the Cerium Induced Impairment of Drug Metabolism in Rat

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