The Effect of Phenobarbital Pretreatment on the Cerium Induced Impairment of Drug Metabolism in Rat

Intravenous injection of the light lanthanon praseodymium nitrate (10 mg/kg) into rats causes a marked liver toxicity which becomes manifest in hypoglycemia, inhibition of RNA and protein synthesis and accumulation of fat in liver tissue. All these effects can be nearly abolished by pretreating rats with a small dose (5 mg/kg) of the same lanthanon. This is neither due to a decreased uptake into the liver nor to an increased excretion rate of the lanthanon. It is assumed that the pretreatment may increase unspecific binding sites or reversibly block them, thus protecting the organism from the irreversible lethal effect.

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Subcellular distribution of phospholipids during liver damage induced by rare earths

Lehmann

Oberdisse

Grajewski

et al. 1975

Arch. Toxicol.

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After intravenous injection of praseodymium nitrate, female Wistar rats develop fatty livers. In contrast to the marked increase of triglycerides, the phospholipid content was only increased by 50%. The subcellular distribution of phospholipids showed that major changes occur in the microsomal fraction within the first 24 hrs. Among the individual phospholipids only phosphatidylcholine and phosphatidylethanolamine concentrations were elevated. Further subfractioning revealed that phospholipid concentration increased in the smooth endoplasmic reticulum, whereas it decreased in the rough endoplasmic reticulum. The individual phospholipids in the smooth endoplasmic reticulum increased to the same degree as did the total phospholipids. On the other hand, in the rough endoplasmic reticulum only the lecithin fraction decreased, while all other phospholipids remained unchanged. Cytochrome P450, cytochrome b5, and glucose 6-phosphatase activity were drastically reduced in the rough endoplasmic reticulum, while no changes could be observed in the smooth endoplasmic reticulum. In the serum, phospholipid concentration fell to half the normal value within the first 24 hrs after praseodymium intoxication.

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The Effect of Phenobarbital Pretreatment on the Cerium Induced Impairment of Drug Metabolism in Rat

Cited by 9 publications

References 18 publications

Toxicology and Pharmacology of the Lanthanides

Toxicology and Pharmacology of the Lanthanides

Lanthanon-induced hepatotoxicity and its prevention by pretreatment with the same lanthanon

Subcellular distribution of phospholipids during liver damage induced by rare earths

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