The Antifungal Activity of Sarcococca saligna Ethanol Extract and its Combination Effect with Fluconazole against Different Resistant Aspergillus Species

Mollazadeh-Moghaddam, Kamyar; Arfan, Muhammad; Rafique, Jamal; Rezaee, S.; Fesharaki, Parisa Jafari; Gohari, Ahmad Reza; Shahverdi, Ahmad Reza

doi:10.1007/s12010-009-8737-2

Cited by 16 publications

(3 citation statements)

References 22 publications

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“…Many plants have been investigated scientifically for antimicrobial activity and a large number of plant products have been shown to inhibit growth of pathogenic bacteria. A large number of these agents appear to have structures and modes of action that are distinct from those of the antibiotic in current use (Mollazadeh et al, 2010). In our study ethanol and methanol extracts of the A. indica were found to show better sensitivity compared with standard antibiotic Erythromycin.…”

Section: Discussionmentioning

confidence: 99%

Analysis of anti-bacterial and anti oxidative activity of Azadirachta indica bark using various solvents extracts

Akeel

Mateen

Janardhan³

et al. 2017

Saudi Journal of Biological Sciences

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Herbal medications have been used for relief of symptoms of disease. Regardless of the great advances observed in current medicine in recent decades, plants still make a significant contribution to health care. An alarming increase in bacterial strains resistant to a number of antimicrobial agents demands that a renewed effort be made to seek antibacterial agents effective against pathogenic bacteria resistant to or less sensitive to current antibiotics. Anti-bacterial activity of stem bark was tested against pathogenic and using various solvent extracts. The in vitro anti-bacterial activity was performed by agar well diffusion method and the results were expressed as the average diameter of zone of inhibition of bacterial growth around the well. The ethanol and methanol extracts showed better anti-bacterial activity with zone of inhibition (20-25 mm) when compared with other tested extracts and standard antibiotic Erythromycin (15 mcg) with zone of inhibition (13-14 mm). Using Fisher's exact test of significance difference was found between two Salmonella strains sensitivity patterns against tested extracts ( ⩽ 0.035). Extracts of stem bark also exhibited significant antioxidant activity, thus establishing the extracts as an antioxidant. The results obtained in this study give some scientific support to the stem bark for further investigation of compounds and in future could be used as drug.

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Section: Discussionmentioning

confidence: 99%

Analysis of anti-bacterial and anti oxidative activity of Azadirachta indica bark using various solvents extracts

Akeel

Mateen

Janardhan³

et al. 2017

Saudi Journal of Biological Sciences

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“…The LD-50 value of salignine showed less toxicity than pysostigmine and neostigmine (Harris et al, 2009). S. saligna extract has been widely used against pain, malaria, rheumatism and skin infections diseases (Mollazadeh et al, 2010). The alkaloid isolated from methanolic extract of S. saligna showed cardio-suppressant, vasodilator, and tracheal relaxant activities (Ghayur and Gilani, 2006).…”

Section: Introductionmentioning

confidence: 99%

Steroidal Alkaloids as an Emerging Therapeutic Alternative for Investigation of Their Immunosuppressive and Hepatoprotective Potential

et al. 2017

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The compounds, sarcovagine-D, alkaloid-C, and holaphylline isolated from Sarcococca saligna were found to possess immunosuppressive activities. These compounds were characterized for in vitro inhibition on human T-cells proliferation and IL-2 production. The compounds showed significant immunosuppressive effect on IL-2 production as well as on phytohemagglutinin stimulated T-cell proliferation in a dose dependent manner. Of all the tested compounds holaphylline was found to be less toxic and safe. These compounds were then evaluated for their in vivo hepatoprotective potential against CCl4, in which alkaloid-C and holaphylline showed markedly reduced liver inflammation and biochemical parameter (ALT, AST, and ALP) of liver injury. The decrease in the activity of hepatic antioxidant enzyme (SOD) was significantly prevented by holaphylline, likewise gradually the levels of MDA and GSH were also normalized compared to silymarin. The CCl4 induced inflammation and necrosis around the central vein of liver was reduced by sarcovagine-D, alkaloid-C and holaphylline, to 8%, 4% to 1% respectively as assessed by histopathology, thus having better hepatoprotective effect compared to positive control. Steroidal alkaloids attenuated the inflammation of liver around the injured central vein region by down regulating the CCl4 induced activation of hepatic macrophages as well as their number respectively. Therefore, the in vitro and in vivo results suggest that steroidal alkaloids from S. saligna could be excellent immunosuppressive and hepatoprotective agents.

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“…Scientific research into the antimicrobial properties of many plants has revealed that a wide variety of plant products can impede the growth of dangerous bacteria. Many of these drugs looked to have unique structures and modes of action from those of the antibiotics now in use [ 35 ]. The leaves of M. oleifera contain numerous phytochemicals with antimicrobial properties, including tannins, phenolic compounds, and flavonoids [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Proximate Analysis of Moringa oleifera Leaves and the Antimicrobial Activities of Successive Leaf Ethanolic and Aqueous Extracts Compared with Green Chemically Synthesized Ag-NPs and Crude Aqueous Extract against Some Pathogens

Ahmed

Marrez

Abdelmoeen

et al. 2023

IJMS

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Research on the use of different parts of the Moringa oleifera plant as a nutritional and pharmaceutical resource for human and animals has increased in recent years. This study aimed to investigate the chemical composition and the TPCs and TFCs of Moringa leaves, the antimicrobial activities of Moringa successive ethanolic, aqueous, crude aqueous extracts, and green-chemically synthesized characterized Ag-NPs. The results indicated that the ethanolic extract recorded the highest activity against E. coli. On the other side, the aqueous extract showed higher activity, and its effects ranged from 0.03 to 0.33 mg/mL against different strains. The MIC values of Moringa Ag-NPs against different pathogenic bacteria ranged from 0.05 mg/mL to 0.13 mg/mL, and the activity of the crude aqueous extract ranged from 0.15 to 0.83 mg/mL. For the antifungal activity, the ethanolic extract recorded the highest activity at 0.04 mg/mL, and the lowest activity was recorded at 0.42 mg/mL. However, the aqueous extract showed effects ranging from 0.42 to 1.17 mg/mL. Moringa Ag-NPs showed higher activity against the different fungal strains than the crude aqueous extract, and they ranged from 0.25 to 0.83 mg/mL. The MIC values of the Moringa crude aqueous extract ranged from 0.74 to 3.33 mg/mL. Moringa Ag-NPs and their crude aqueous extract may be utilized to boost antimicrobial attributes.

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The Antifungal Activity of Sarcococca saligna Ethanol Extract and its Combination Effect with Fluconazole against Different Resistant Aspergillus Species

Cited by 16 publications

References 22 publications

Analysis of anti-bacterial and anti oxidative activity of Azadirachta indica bark using various solvents extracts

Analysis of anti-bacterial and anti oxidative activity of Azadirachta indica bark using various solvents extracts

Steroidal Alkaloids as an Emerging Therapeutic Alternative for Investigation of Their Immunosuppressive and Hepatoprotective Potential

Proximate Analysis of Moringa oleifera Leaves and the Antimicrobial Activities of Successive Leaf Ethanolic and Aqueous Extracts Compared with Green Chemically Synthesized Ag-NPs and Crude Aqueous Extract against Some Pathogens

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