The antihyperlipidaemic and hepatoprotective effect of Ipomoea batatas L. leaves extract in high-fat diet rats

Mahfudh, Nurkhasanah; Sulistyani, Nanik; Syakbani, Muhammad; Dewi, Athifah Candra

doi:10.11591/ijphs.v10i3.20777

Cited by 5 publications

(8 citation statements)

References 21 publications

(24 reference statements)

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“…The finding is also consistent with another previous study, which stated that purple sweet potato leaf extract was able to significantly reduce cholesterol and triglyceride levels and that it had a protective effect on the rat liver against damages from high-fat diets induction (Mahfudh et al, 2021). Purple sweet potato extract contains flavonoids that work by inhibiting cholesterol absorption, increasing bile excretion, and inhibiting HMG-CoA.…”

Section: Cholesterol and Triglyceride Levelssupporting

confidence: 93%

Antioxidant and Antihyperlipidemic Effect of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) and Red Yeast Rice Combination In Hypercholesterol Rats

2022

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Hyperlipidemia is a condition of lipid such as cholesterol and triglycerides in the blood are high, which is the cause of other diseases. This condition also causes an increase in free radicals resulting in oxidative stress. Purple sweet potato leaves and red yeast rice have been reported to have antihyperlipidemic and antioxidant activity in several studies. This study aimed to examine the effect of the combination of purple sweet potato leaves extract and red yeast rice on cholesterol and triglyceride levels as well as MDA levels and GPx activity on rats induced by a high-fat diet. Experimental animals were randomly divided into 6 groups of 5 mice each: group 1 being the normal group; group 2 positive control; group 3 negative control; group 4 purple sweet potato leaf extract 400 mg/kg BW; group 5 red yeast rice 40 mg/kg BW; group 6 combination of purple sweet potato leaf extract 360 mg/kg BW and red yeast rice 40 mg/kg BW. Rats were treated with high-fat feed for 28 days, on day 15-28 were given oral preparations. At the end of the study, all rats were blood drawn to measure cholesterol and triglyceride levels, then rats were sacrificed and the liver was taken to measure MDA and glutathione peroxidase levels. The administration of purple sweet potato leaf extract, red yeast rice, and their combination significantly (p<0,05) reduced cholesterol, triglyceride, and MDA levels, and increased GPx activity, with the best effect in the combination group. This finding showed that the combination of purple sweet potato leaf extract and red yeast rice had antihyperlipidemic and antioxidant activity in hypercholesterol rats.

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Section: Cholesterol and Triglyceride Levelssupporting

confidence: 93%

Antioxidant and Antihyperlipidemic Effect of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) and Red Yeast Rice Combination In Hypercholesterol Rats

2022

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“…ZC rhizome contains phenolic compounds, and the total phenolic content of ZC rhizome is 2.71 g GAE/100 g extract or 0.30 g GAE/100 g simplicia. In vivo research using 30 rats given ZC rhizome extract at a dose of 400 mg/kg showed a significant reduction in total cholesterol (Mahfudh et al, 2021).…”

Section: Effect Of Zc-psp Biscuits On Total Cholesterol Levels In Rat...mentioning

confidence: 97%

“…The antioxidant mechanism of curcumin is related to the presence of the H atom in the phenolic group. The action of curcumin as a radical scavenger is that it can maintain the integrity of cell membranes during oxidative degradation events due to the presence of oxygen radicals and other reactive radicals (Mahfudh et al, 2021).…”

Section: Effect Of Zc-psp Biscuits On Total Cholesterol Levels In Rat...mentioning

confidence: 99%

“…Oxidative stress can be characterised by a decrease in SOD. The content of curcumin in ZC rhizomes will increase the activity of SOD, and restore the oxidative balance (Mahfudh et al, 2021). In addition to curcumin, the rhizome of ZC also contains flavonoid compounds that have antioxidant activity.…”

Section: Effect Of Zc-psp Biscuits On Total Cholesterol Levels In Rat...mentioning

confidence: 99%

“…In addition, the potential for ROS of curcumin limits the risk of lipid peroxidation that triggers an inflammatory response that leads to cardiovascular disease and atherosclerosis. Other phenolic content such as flavonoids and tannins are also involved in decreasing triglyceride levels through the inhibition of lipid absorption (Mahfudh et al, 2021).…”

Section: Effects Of Zc-psp Biscuits On Triglyceride Levels In Rats Fe...mentioning

confidence: 99%

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Development of biscuits from bangle (Zingiber cassumunar Roxb.) rhizome flour and purple sweet potato (Ipomoea batatas (L.) Lam.) flour, and their potential as antihyperlipidemic functional foods

Mahfudh,

Wardani,

Kumalasari

et al. 2023

IFRJ

Self Cite

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Zingiber cassumunar Roxb. (ZC) and purple sweet potato (PSP) are the potential sources of antioxidants, and play an important role in reducing blood fat levels, and encourage the development of antihyperlipidemic products, usually in the form of biscuits. Biscuits are favoured by consumers because of their delicious and varied tastes, relatively cheap prices, and complete nutritional content. In the present work, biscuits were made with three formula variations of ZC:PSP ratios namely F1 (0.75:5.25 g), F2 (0.45:5.55 g), and F3 (0.2:5.72 g), and then tested for their physical quality based on Indonesian National Standard (SNI), and hedonic testing to get the best formula, including aroma, colour, texture, and taste. Furthermore, in vivo antihyperlipidemic testing was carried out on the best formula. The test was conducted by dividing Sprague-Dawley rats into four groups, namely normal, negative, positive (Nutrive Benecol animal, 3.6 mL/day for 28 days), and the best formula (1.944 g/day for 28 days). All groups were induced with high fat diet (HFD) for 28 days, except normal group. Results showed a decrease in cholesterol, triglyceride, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT) levels in the normal group with values of 99.09 mg/dL, 90.36 mg/dL, 22.66 U/I, and 39.41 U/I, respectively, as compared to the negative group with values of 195.01 mg/dL, 142.44 mg/dL, 29.05 U/I, and 77.19 U/I, respectively. There was an increase in cholesterol, triglyceride, SGOT, and SGPT levels in the positive group with values of 108.39 mg/dL, 96.12 mg/dL, 24.11 U/I, and 48.55 U/I, respectively, as compared to the normal group test. A combination of biscuits made from ZC and PSP flour could have the potential to reduce lipid levels in the blood, and encourage the development of antihyperlipidemic products.

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Combination of purple sweet potato (Ipomoea batatas L.) leaf extract with metformin on blood glucose and total cholesterol levels of albino rats induced by high-fat diet and streptozotocin

Saing,

Harahap,

Sitorus

2024

Int J Basic Clin Pharmacol

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Background: Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion, often accompanied by hypercholesterolemia. Metformin is a first-line antihyperglycemic drug that is often combined with other antihyperglycemic drugs. Purple sweet potato leaves have been widely studied to reduce glucose and cholesterol levels. Methods: This study was an experimental study using rats induced with a high-fat diet and streptozotocin, which were divided into 8 treatment groups, namely groups given CMC Na 0.5%, Metformin 45 mg/kg BW, Purple Sweet Potato Leaf Extract (SPLE) 200 mg/kg BW, SPLE 400 mg/kg BW, SPLE 800 mg/kg BW, SPLE 200 mg/kg BW with metformin 45 mg/kg BW, SPLE 400 mg/kg BW with metformin 45 mg/kg BW, and SPLE 800 mg/kg BW with metformin 45 mg/kg BW. Results: After treatment for 28 days with SPLE doses of 200 mg, 400 mg, and 800 mg/kg BW, both single doses and combinations with metformin showed a decrease in fasting blood glucose levels and total cholesterol, which were statistically significantly different (p<0.05) between treatment groups using the one-way ANOVA. The combination of SPLE 800 mg/kg BW with metformin normalized blood glucose levels of 93.50±4.93 mg/dl.Conclusion: The combination of purple sweet potato leaf extract with metformin is more effective in reducing blood glucose and total cholesterol levels compared to the single administration of metformin and SPLE.

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The antihyperlipidaemic and hepatoprotective effect of Ipomoea batatas L. leaves extract in high-fat diet rats

Cited by 5 publications

References 21 publications

Antioxidant and Antihyperlipidemic Effect of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) and Red Yeast Rice Combination In Hypercholesterol Rats

Antioxidant and Antihyperlipidemic Effect of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) and Red Yeast Rice Combination In Hypercholesterol Rats

Development of biscuits from bangle (Zingiber cassumunar Roxb.) rhizome flour and purple sweet potato (Ipomoea batatas (L.) Lam.) flour, and their potential as antihyperlipidemic functional foods

Combination of purple sweet potato (Ipomoea batatas L.) leaf extract with metformin on blood glucose and total cholesterol levels of albino rats induced by high-fat diet and streptozotocin

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