The antihypertensive effect of cysteine

Vasdev, Sudesh; Singal, Pawan K.; Gill, Vicki

doi:10.1055/s-0031-1278316

Cited by 60 publications

(69 citation statements)

References 205 publications

(292 reference statements)

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“…The dietary approaches to ttop hypertension (DASH) study confirmed that the DASH diet, which was rich in vegetables, fruits and low-fat dairy products, low in fat, and including whole grains, poultry, fish and nuts, and lowered blood pressure. 19 Other results confirmed the correlation between ROS and diastolic levels in this study as positive. Although this study did not feature a complete data history of hypertension, the theory mentions the potential occurrence of this condition because ROS potentially results in hypertension by inducing vascular contraction (Figure 2).…”

Section: Discussionsupporting

confidence: 86%

Correlation between reactive oxygen species and oral conditions in elderly individuals with hypertension: a preliminary study

Nur’aeny

Hidayat

Wahyuni

2018

Dent. J. (Maj. Ked. Gigi)

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Section: Discussionsupporting

confidence: 86%

Correlation between reactive oxygen species and oral conditions in elderly individuals with hypertension: a preliminary study

Nur’aeny

Hidayat

Wahyuni

2018

Dent. J. (Maj. Ked. Gigi)

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“…It has been proposed that cysteine and its storage form, glutathione, could exert antihypertensive effects by modulating the levels of nitric oxide (NO) and other vasoactive molecules, as well as by reducing oxidative stress, insulin resistance, and advanced glycation products. 7 Although cysteine is one of the least abundant amino acids, it often occurs in the functional sites of proteins.…”

Section: Discussionmentioning

confidence: 99%

“…16 Several studies have shown that dietary supplementation with the cysteine derivate N-acetylcysteine (NAC) can prevent or attenuate increased blood pressure in animal models of hypertension. 7,17 In addition, using NAC as an adjunct to other hypertensive therapies leads to a decrease in blood pressure in humans. 7,18 The availability of cysteine is a major determinant of the biosynthesis of glutathione, which is an important antioxidant.…”

Section: Discussionmentioning

confidence: 99%

“…Cysteine may exert its antihypertensive effects directly or via its storage form, glutathione, by reducing oxidative stress and advanced glycation end products, improving insulin sensitivity and glucose metabolism, and modulating nitric oxide levels. 7 To the best of our knowledge, no study has examined the association between cysteine intake and risk of stroke.In a previous study, based on data from the Swedish Mammography Cohort (SMC), we observed inverse associations of total and animal protein intakes with stroke incidence. …”

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confidence: 99%

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Dietary Cysteine and Other Amino Acids and Stroke Incidence in Women

Larsson

Håkansson

Wolk

2015

Stroke

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Evidence from animal studies, randomized trials, and observational studies indicates that dietary protein intake is inversely associated with blood pressure 1-3 and the risk of stroke. 4,5 A recent meta-analysis of 7 prospective studies found that intake of total and animal protein, but not vegetable protein, was significantly inversely associated with stroke risk. 4 Proteins in the diet are composed of several amino acids, each with different chemical properties. Cysteine is a nonessential sulfur-containing amino acid that may, at least in part, be responsible for the potential blood pressure and strokereducing effects of a high-protein diet. It is more abundant in animal and cereal proteins than in legume proteins. 6 Foods rich in cysteine include poultry, egg, beef, and whole grains. Cysteine may exert its antihypertensive effects directly or via its storage form, glutathione, by reducing oxidative stress and advanced glycation end products, improving insulin sensitivity and glucose metabolism, and modulating nitric oxide levels. 7 To the best of our knowledge, no study has examined the association between cysteine intake and risk of stroke.In a previous study, based on data from the Swedish Mammography Cohort (SMC), we observed inverse associations of total and animal protein intakes with stroke incidence. 8In this study, we evaluated the a priori hypothesis that cysteine intake is inversely associated with risk of stroke, and that cysteine may have contributed to our previous observed finding for dietary protein. We also provide results for other amino acids, most of which are highly correlated with protein intake, in relation to stroke risk. Methods Study PopulationThis study was based on data from the SMC, which is a populationbased prospective cohort study of Swedish women. 9 In the autumn of 1997, 56 030 participants of the SMC obtained a comprehensive questionnaire that included ≈350 items on diet, other lifestyle factors, etc; 39 227 women (70%) returned a completed questionnaire. We excluded women with an erroneous or a missing personal identification number (n=243), women who did before start of follow-up (January 1, 1998; n=26), women with a diagnosis of cardiovascular disease (n=2492) or cancer (n=1811) before start of follow-up, and women with an implausibly high or low energy intake (ie, 3 SDs from the log e -transformed mean energy intake; n=405). After exclusions, 34 250 women aged 49−83 years remained for analysis. The study was approved by the Regional Ethical Review Board at the Karolinska Institutet in Stockholm.Background and Purpose-Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence. Methods-We used data from the Swedish Mammography Cohort, a population-based prospective cohort of 34 250 women who were free of cardiovascular disease and cancer and had completed a food-frequency questionnaire about diet and other risk factors for stro...

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“…In addition, ox LDL, HSCRP, ICAM, VCAM, fibrinogen and PAI-1 were decreased while HDL, NO and endothelial postischemic vasodilation increased [141] . NAC increases NO via IL-1b and increases iNOS MRNA, increases glutathione by increasing cysteine levels, reduces the affinity for the AT1 receptor by disrupting disulfide groups, blocks the L type calcium channel, lowers homocysteine, and improves IMT [141,[322][323][324] . The recommended dose is 500 to 1000 mg bid.…”

Section: Alpha Lipoic Acidmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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The antihypertensive effect of cysteine

Cited by 60 publications

References 205 publications

Correlation between reactive oxygen species and oral conditions in elderly individuals with hypertension: a preliminary study

Correlation between reactive oxygen species and oral conditions in elderly individuals with hypertension: a preliminary study

Dietary Cysteine and Other Amino Acids and Stroke Incidence in Women

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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