The Antiinflammatory Potential of Flavonoids

Catarino, Marcelo D.; Talhi, Oualid; Rabahi, Amal; Silva, Artur M. S.; Cardoso, Susana M.

doi:10.1016/b978-0-444-63602-7.00003-5

Cited by 33 publications

(18 citation statements)

References 96 publications

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“…Among both extracts, the hydroethanolic showed the highest inhibitory effects in NO production by LPS-stimulated RAW264.7 cells (EC 50 = 251 µg/mL for A. leucotrichus and 294 µg/mL for M. oleifera), while M. oleifera leaves decoction was less active (321 µg/mL), and A. leucotrichus decoction did not revealed anti-inflammatory activity. Several authors (Catarino, Talhi, Rabahi, Silva, & Cardoso, 2016;Sobral et al, 2016) reported that plant phenolic compounds act as anti-inflammatory molecules by different levels of inhibitory action in the LPS-induced NO production. The polyphenols that have a higher number of hydroxyl groups (Gardi et al, 2015), such as the ones identified in this study, are probably the activators of NOproduction inhibition.…”

Section: Bioactive Properties Evaluationmentioning

confidence: 99%

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Ziani

Rached

Bachari

et al. 2019

Journal of Functional Foods

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Edible Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck are largely used in the Algerian Sahara. In this context, soluble sugars, fatty acids, organic acids, and tocopherols were characterized. Decoctions and hydroethanolic extracts were studied regarding their phenolic compounds by HPLC-DAD-ESI/MSn, and invitro cytotoxic, anti-inflammatory, and antibacterial activities were evaluated. Results indicate high contents of carbohydrates (glucose and sucrose) and significant levels of protein and mineral were recorded for both plants. Malic acid was the major organic acid alongside with α-tocopherol, while PUFA was predominant in M. oleifera and MUFA in A. leucotrichus. Flavonoid derivatives were the most abundant group, being luteolin-O-(malonylglucoside) the main compound in A. leucotrichus and quercetin-3-O-(6″-malonyl-glucoside) and 3-O-caffeoylquininc acid the major molecules in M. oleifera. Extracts exhibited significant cytotoxicity on Hela and MCF-7 cell lines. The anti-inflammatory activity was also higher in the hydroethanolic extracts, which also revealed the highest antibacterial effects, especially for Gram-positive bacteria. leucotrichus Coss. & Dur. (Apiaceae) is an endemic plant in North Africa and is widely used in traditional medicine, especially in the southern Algerian Sahara and Tassili regions (Louail et al., 2016). Leaves and seeds of this plant are consumed in the form of infusions and/or decoctions for several therapeutic cases, such as liver and digestive system ailments, gastroenteritis, diabetes, as also for blood pressure and chest pain (Halla, Boucherit, Boucherit-otmani, Zohra, & Rahmani, 2018; Louail et al., 2016). The fruits are often used as a spice during culinary preparation, and leaves are used as a flavoring herbal in teas (Halla et al., 2018; Louail et al., 2016). Nevertheless, most phytochemical and biological studies on A. leucotrichus are related to the volatile compounds from the essential oils (Gherraf et al., 2017; Halla et al., 2018), and few scientific studies have been conducted towards the phenolic compounds and their functional properties. According to a recent study conducted by Halla, Heleno, Costa, Fernandes, Calhelha, Boucherit, Rodrigues, Ferreira, and Barreiro (2018) using colorimetric reactions, flavonoids, condensed and hydrolysable tannins, coumarins, alkaloids, and terpenoids were found in the Algerian A. leucotrichus aqueous extract obtained by decoction and in the hydromethanolic extract. El Haci, Mazari, Gherib, and Atik Bekkara (2018) reported moderate

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Section: Bioactive Properties Evaluationmentioning

confidence: 99%

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Ziani

Rached

Bachari

et al. 2019

Journal of Functional Foods

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“…Many polyphenols, especially flavonoids possess potent anti-inflammatory properties [16][17][18][19]. and regulate immunity [6,7,17,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Polyphenols in the treatment of autoimmune diseases

Khan

Sureda

Belwal

et al. 2019

Autoimmunity Reviews

181

108

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In addition to protecting body from infections and diseases, the immune system produces autoantibodies that can cause complex autoimmune disorders, such as Type I diabetes, primary biliary cirrhosis, rheumatoid arthritis, and multiple sclerosis, to name a few. In such cases, the immune system fails to recognize between foreign agents and its own body cells. Different factors, such as genetic factors (CD25, STAT4), epigenetic factors (DNA methylation, histone modifications) and environmental factors (xenobiotics, drugs, hormones) trigger autoimmunity. Glucocorticoids, nonsteroidal anti-inflammatory drugs (NSAIDs), immunosuppressive and biological agents are

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“…The regulation of such pro-inflammatory molecules is mediated by several transcription factors. Of these, NF-κB is perhaps one of the most important regulators of the innate immunity, being responsible for the transcription of various genes involved in the inflammatory signaling cascades [23]. Under normal conditions, NF-κB is located in the cytoplasm bound to inhibitory proteins κB (IκB), which exist in the forms α, β and ε, the former being the most well studied [24].…”

Section: Introductionmentioning

confidence: 99%

Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway

Catarino

Silva

Cruz

et al. 2020

IJMS

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Due to their large spectrum of bioactive properties, much attention has recently been drawn to phlorotannins—i.e., phenolic compounds characteristic from brown macroalgae. This study aimed to evaluate the antioxidant and anti-inflammatory properties of F. vesiculosus phlorotannin extracts and purified fractions. Overall, the crude extract and its ethyl acetate fraction (EtOAc) showed good radical scavenging activity, particularly towards nitric oxide (NO•). Subsequent subfractions of EtOAc (F1 to F9) with different molecular weights were then shown to inhibit lipopolysaccharide-induced NO• production in macrophages, with stronger effects being observed for fractions of lower MWs. Of the three intracellular markers analyzed, inducible NO• synthase showed the highest sensitivity to almost all the phlorotannin-rich samples, followed by interleukin 1β and cyclooxygenase 2, which was only inhibited by F2. Furthermore, this subfraction inhibited the phosphorylation and degradation of inhibitory protein κBα, thus preventing the activation of NF-κB and blocking the inflammatory cascade at the transcriptional level. This sample was characterized by the presence of a major compound with a deprotonated molecular ion at m/z 507 with a fragmentation pattern coherent with that of a phlorotannin derivative. Overall, this work unveiled some of the mechanistic aspects behind the anti-inflammatory capacity of phlorotannins from F. vesiculosus, endorsing its use as a possible natural source of anti-inflammatory compounds.

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The Antiinflammatory Potential of Flavonoids

Cited by 33 publications

References 96 publications

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Polyphenols in the treatment of autoimmune diseases

Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway

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