The antimorphic mode of action of lethal Abruptex alleles of the Notch locus in Drosophila melanogaster

The receptor encoded by the Notch gene plays a central role in preventing cells from making decisions about their fates until appropriate signals are present. This function of Notch requires the product of the Suppressor of Hairless gene. Loss of either Notch or Suppressor of Hairless function results in cells making premature and incorrect cell fate decisions, whilst increases in Notch signalling prevent cells from making these decisions. Here we find that the proneural clusters are not established correctly in certain Abruptex mutations of Notch and this failure to establish proneural clusters correctly is not due to increased Notch signalling during lateral inhibition. In addition we show that the overexpression of certain dominant negative Notch molecules can disrupt the initiation of proneural cluster development in a manner similar to the Abruptex mutants.

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The Abruptex Mutations of Notch Disrupt the Establishment of Proneural Clusters in Drosophila

Brennan

Tateson

Lieber

et al. 1999

Developmental Biology

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Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus

Kelley

Kidd

Deutsch

et al. 1987

Cell

216

114

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Notch is required for wingless signaling in the epidermis of Drosophila

Couso¹,

Arias²

1994

Cell

169

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The antimorphic mode of action of lethal Abruptex alleles of the Notch locus in Drosophila melanogaster

Cited by 8 publications

References 13 publications

The Abruptex Mutations of Notch Disrupt the Establishment of Proneural Clusters in Drosophila

The Abruptex Mutations of Notch Disrupt the Establishment of Proneural Clusters in Drosophila

Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus

Notch is required for wingless signaling in the epidermis of Drosophila

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