The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta‐analysis of animal studies

Abstract

Current evidence has shown antioxidant activity of artichoke as a potent source of antioxidant compounds. However, it seems that the antioxidant activity of artichokehas not yet been reviewed. Therefore, the present study was designed to perform a systematic review of human studies, animal models, and in vitro systems and to conduct a meta-analysis of animal studies on the antioxidant effects of artichoke. We searched four electronic databases till April 2018 using relevant keywords. All English language articles were assessed. For animal studies, standardized mean difference was pooled using a random effects model. The included studies were evaluated for eligibility and risk of bias. Thirty-nine articles (two human, 23 animal, and 14 in vitro studies) were reviewed. The results of in vitro systems supported the antioxidant effect of artichoke, whereas limited clinical trials indicated no change or a slight improvement of antioxidant status. Finding of animal studies indicated that artichoke extract supplementation increased superoxide dismutase, catalase, glutathione, and glutathione peroxidase level in liver, as well as, decreased malondialdehyde level in liver and plasma of animals with induced disease significantly compared with comparison group. This meta-analysis provided convincing evidence for antioxidant activity of artichoke in animals.

Evidences on Molecules Most Frequently Included in Canine and Feline Complementary Feed to Support Liver Function

“…Antioxidative, hepatoprotective, bile expelling, and lipid-lowering effects have been associated with the artichoke leaf extract [40]. In particular, Salekzamani et al [41] reviewed the Cynara scolymus antioxidant activities in human, animal, and in vitro studies. Only data obtained in in vitro studies supported the antioxidant activities of artichoke (leaves or heads extracts) in the prevention or reduction of the oxidative stress.…”

Engilen: from different therapeutic possibilities to effective clinical use

“…Относительно недавно опубликован систематический обзор и метаанализ 39 исследований, в которых анализировалось влияние артишока на состояние печени [73]. Следует отметить, что из трайлов, вошедших в метаанализ, в двух исследования проведены с участием людей, в 23 -с привлечением лабораторных животных, а 14 работ проведены в условиях in vitro.…”

“…Изучив результаты экспериментальных работ, S. Salekzamani и соавт. (2019) подтвердили, что экстракт листьев артишока повышает содержание супероксиддисмутазы, каталазы, глутатиона в печени, а также снижает концентрацию малонового диальдегида в печени и плазме крови лабораторных животных по сравнению с плацебо [73].…”

Meta‐analysis of dietary supplementation effect of turmeric and curcumin on growth performance in fish

“…Meta‐analysis is a set of techniques used to combine the results of various independent studies into single report in order to create a precise estimate of an ‘effect’ (Hoffman 2015). This statistic method was largely implemented in medical research for highlighting the multiple studies performed by different scientific teams in various environments (Ioannidis 2012; Salekzamani et al 2018). Recently, some authors investigated this approach in aquaculture to assess the effect of plant protein inclusion on fish growth (Sales 2009; Hua & Bureau 2012; Collins et al 2013; Novriadi 2017).…”