The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis

Sousa, Caio Victor; Sales, Marcelo Magalhães; Rosa, Thiago Santos; Lewis, John E.; Andrade, Rosângela Vieira de; Simões, Herbert Gustavo

doi:10.1007/s40279-016-0566-1

Cited by 253 publications

(183 citation statements)

References 105 publications

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“…Increased exercise capacity due to improved muscle function restores glucose metabolism via means of insulin-dependent and -independent mechanisms (Holloszy, 2005). Regular physical activity has been demonstrated to exert protective effects against oxidative stress via induction of antioxidant pathways (de Sousa et al, 2017). When combined with proper dietary regime, exercise training is also effective in combating obesity, achieving better weight-control, as well as restoring endothelial function which greatly reduces individual's risk of cardiovascular comorbidities (Johansson, Neovius, & Hemmingsson, 2014;Moien-Afshari et al, 2008).…”

Section: Physical Inactivity: a Cause Or A Consequence?mentioning

confidence: 99%

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Chan

Selemidis

Bozinovski

et al. 2019

Pharmacology & Therapeutics

116

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a b s t r a c t a r t i c l e i n f oChronic obstructive pulmonary disease (COPD) is a major incurable global health burden and is currently the 4th largest cause of death in the world. Importantly, much of the disease burden and health care utilisation in COPD is associated with the management of its comorbidities (e.g. skeletal muscle wasting, ischemic heart disease, cognitive dysfunction) and infective viral and bacterial acute exacerbations (AECOPD). Current pharmacological treatments for COPD are relatively ineffective and the development of effective therapies has been severely hampered by the lack of understanding of the mechanisms and mediators underlying COPD. Since comorbidities have a tremendous impact on the prognosis and severity of COPD, the 2015 American Thoracic Society/European Respiratory Society (ATS/ERS) Research Statement on COPD urgently called for studies to elucidate the pathobiological mechanisms linking COPD to its comorbidities. It is now emerging that up to 50% of COPD patients have metabolic syndrome (MetS) as a comorbidity. It is currently not clear whether metabolic syndrome is an independent co-existing condition or a direct consequence of the progressive lung pathology in COPD patients. As MetS has important clinical implications on COPD outcomes, identification of disease mechanisms linking COPD to MetS is the key to effective therapy. In this comprehensive review, we discuss the potential mechanisms linking MetS to COPD and hence plausible therapeutic strategies to treat this debilitating comorbidity of COPD.

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Section: Physical Inactivity: a Cause Or A Consequence?mentioning

confidence: 99%

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Chan

Selemidis

Bozinovski

et al. 2019

Pharmacology & Therapeutics

116

View full text Add to dashboard Cite

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“…Furthermore, Karabulut et al [82] reported that following a 12-week aerobic exercise program, the lipid peroxidation marker malondiadehyde (MDA) significantly decreased whereas the antioxidant parameters SOD and GSH significantly increased. More recently, a systematic review and meta-analysis conducted by de Sousa et al [83] reported that physical activity induced antioxidant effects and decreased pro-oxidant effects regardless of the type of exercise, volume, intensity, and population studied. Consequently, it can be concluded that exercise is antioxidant in nature and can balance the redox state to elicit positive health outcomes.…”

Section: Antioxidants and Fshdmentioning

confidence: 99%

Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature

Denny

Heather

2017

Oxidative Medicine and Cellular Longevity

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Facioscapulohumeral muscular dystrophy (FSHD) is an inherited myopathy affecting approximately 1 in 7500 individuals worldwide. It is a progressive disease characterised by skeletal muscle weakness and wasting. A genetic mutation on the 4q35 chromosome results in the expression of the double homeobox 4 gene (DUX4) which drives oxidative stress, inflammation, toxicity, and atrophy within the skeletal muscle. FSHD is characterised by oxidative stress, and there is currently no cure and a lack of therapies for the disease. Antioxidants have been researched for many years, with investigators aiming to use antioxidants therapeutically for oxidative stress-associated diseases. This has included both natural and synthetic antioxidants. The use of antioxidants in preclinical or clinical models has been largely successful with a plethora of research reporting positive results. However, when translated to clinical trials, the use of antioxidants as a therapeutic intervention for a variety of disease has been largely unsuccessful. Moreover, specifically focusing on FSHD, limited research has been conducted on the use of antioxidants as a therapy in either preclinical or clinical models. This review summarises the current state of antioxidant use in the treatment of FSHD and discusses their potential avenue for therapeutic use for FSHD patients.

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“…Karabulut et al reported a decrease in malondialdehyde (MDA) production and improved anti‐oxidant status after regular exercise training . A meta‐analysis study stated that resistance training has an effect on total anti‐oxidant capacity (TAC) and results in balancing the redox state, which in turn leads to a reduction in metabolic and immune‐related diseases …”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and anti‐oxidant responses to regular resistance training in young and older adult women

Alikhani

Sheikholeslami-Vatani

2019

Geriatrics Gerontology Int

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Aim The aging process is associated with increased production of free radicals, but regular exercise training might create a balance between oxidative stress and the anti‐oxidant system. The aim of the present study was to investigate the effect of resistance training (RT) on the serum levels of tumor necrosis factor‐α, malondialdehyde, total anti‐oxidant capacity and nuclear factor‐κB in young and older adult women. Methods A total of 44 women were divided into four groups: older‐training, older‐control, young‐training and young‐control. The experimental groups carried out 12 weeks of RT with an intensity of 75% one repetition maximum. Results After finishing the RT program, total anti‐oxidant capacity and nuclear factor‐κB in both the young and older adult training groups were significantly increased, whereas malondialdehyde in the young and the older exercising groups decreased. In addition, malondialdehyde in both the older and young groups, and total anti‐oxidant capacity in only the young group, were respectively lower and higher compared with their inactive counterparts. No significant changes in tumor necrosis factor‐α occurred in training groups after the 12‐week intervention, but the older and younger training groups had a significant difference with the young control group in the post‐test. Conclusions It seems that the strengthening of the anti‐oxidant system resulting from regular RT in older adults is similar to those of young people. Geriatr Gerontol Int 2019; 19: 419–422.

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The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis

Cited by 253 publications

References 105 publications

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature

Oxidative stress and anti‐oxidant responses to regular resistance training in young and older adult women

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