The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes

Alpsoy, Lokman; Yıldırım, Abdülkadir; Ağar, Güleray

doi:10.1177/0748233709103413

Cited by 105 publications

(72 citation statements)

References 40 publications

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“…The effects of vitamin E seemed to be stronger in obese patients compared with controls. Our findings corroborated previous studies [56] [60]- [62].…”

Section: Discussionsupporting

confidence: 93%

Vitamins C, E, and NADH on in Vitro Lymphocyte Proliferation and Redox Status among Obese Patients

Meraou¹,

Merzouk²,

Saidi³

et al. 2016

FNS

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Background: The prevalence of overweight and obesity associated with oxidative stress and immune abnormalities is continuously increasing. Antioxidant supplementations might counteract potential damage caused by ROS to cellular tissues. Objective: To determine the role of vitamins on immune improvement during obesity, we investigated in vitro effects of vitamins C, E, and NADH on mitogen-stimulated proliferation, Th1-and Th2-type cytokine production, and oxidant/antioxidant status of lymphocytes isolated from obese patients. Methods: Peripheral blood lymphocytes were isolated using a density gradient of Histopaque. They were in vitro cultured and stimulated by Con A in the presence or absence of vitamins. Cell proliferation was determined by MTT assay and interleukin-2, interleukin-4 and interferon-γ (INFγ) secretions. Cell oxidant/antioxidant balance was studied by assaying glutathione (GSH), malondialdehyde (MDA), carbonyl protein levels, catalase activity and micronucli frequency. Results: Obesity is associated with enhanced oxidative stress response. Indeed, vitamin C, E and NADH improved significantly lymphocyte proliferation and diminished cellular oxidative stress. Conclusion: Treatments of lymphocytes with vitamins had beneficial effects on lymphocyte proliferation, cytokines secretions and redox status, generating an anti-inflammatory profile and should be considered in therapeutic approaches for normalizing immune cell function in obesity.

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“…The effects of vitamin E seemed to be stronger in obese patients compared with controls. Our findings corroborated previous studies [56] [60]- [62].…”

Section: Discussionsupporting

confidence: 93%

Vitamins C, E, and NADH on in Vitro Lymphocyte Proliferation and Redox Status among Obese Patients

Meraou¹,

Merzouk²,

Saidi³

et al. 2016

FNS

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“…In the present study, MDA was significantly elevated in the wheat milling workers with high serum levels of AFB1/alb compared to the controls. The increased production of MDA; as a late biomarker of oxidative stress regardless of the way it is induced, could explain the dose-dependent high cytotoxic and genotoxic potential of AFB1 [30]. It was reported that AFB1 generates ROS that has an important contribution in the hepatic damaging process [7], and that could explain the significant correlation between MDA and the liver enzymes AST, GGT and P53 detected in the present study.…”

Section: Discussionsupporting

confidence: 52%

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Saad-Hussein¹,

Abdalla²,

Shousha³

et al. 2014

Open Access Maced J Med Sci

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Aim: The study aimed to estimate oxidative role of aflatoxin B1 (AFB1) on the liver in wheat milling workers. Materials and Methods:Case-control study was conducted to compare between the levels of AFB1/albumin (AFB1/alb), liver enzymes (ALT, AST, GGT, and ALP), P53, MDA, GST, SOD, zinc and vitamin C in 35 wheat milling workers and 40 control subjects.Results: Statistical analysis revealed that ALT, AST, GGT, ALP, P53, MDA, GST and SOD in workers were significantly elevated compared to their controls. In the milling workers, there were significant correlations between MDA levels and the levels of AST, GGT, and P53, while, P53 was inversely correlated with GST and SOD activities. There were significant correlations between Zn levels and GGT, GST and SOD activities, between vitamin C and GST activities, and vitamin C inversely correlated with MDA. Conclusion:The present study concluded that the oxidative stress of AFB1 elevated the MDA and the liver enzymes in wheat milling workers. GST has a crucial role in the detoxification of aflatoxin and SOD as a scavenger antioxidant increased in the workers to overcome the oxidative toxic effects of AFB1 on the liver of the workers, and roles of Zn and vitamin C were significant in activation of these processes.

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“…Exposure to heavy metal (Ni, Co, Cr, Zn) levels in the growth medium resulted in increased vitamin A of bean plants (Fig 1A, 2A, 3A, 4A). Vitamin A (retinol) is the most eff ective naturally occurring quencher of singlet oxygen; it is a radical scavenger and an effective chain-breaking antioxidant (Alpsoy et al, 2009). Vitamin E is a potent lipid-soluble antioxidant, with the ability to quench free radicals directly, and functions as a membrane stabilizer (Clarke et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Physiological behavior of bean (phaseolus vulgaris l.) Seedlings under metal stress

Zengin

2013

Biol. Res.

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The eff ects of nickel, cobalt, chromium and zinc on the content of vitamins A, E and C, malondialdehyde (MDA), chlorophyll and carotenoids were investigated in bean seedlings (Phaseolus vulgaris L.) grown in Hoagland solution Control and heavy metal-treated plants were grown for ten days in Hoagland solution. Vitamin A, E, and C content were measured in primary leaves by high performance liquid chromatographic (HPLC). MDA, chlorophyll and carotenoids were measured in leaves by spectrophotometer. In heavy metal treated plants, the levels of MDA, vitamins A, E and C and carotenoids signifi cantly increased, while chlorophyll content decreased in leaves of seedlings. The results indicate that heavy metals caused an oxidative stress in bean plants. The strongest eff ect on vitamins A, E and C, MDA, chlorophyll and carotenoids was found in plants exposed to nickel, followed by the sequence cobalt > chromium> zinc.

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The antioxidant effects of vitamin A, C, and E on aflatoxin B₁-induced oxidative stress in human lymphocytes

Cited by 105 publications

References 40 publications

Vitamins C, E, and NADH on <i>in Vitro</i> Lymphocyte Proliferation and Redox Status among Obese Patients

Vitamins C, E, and NADH on <i>in Vitro</i> Lymphocyte Proliferation and Redox Status among Obese Patients

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Physiological behavior of bean (phaseolus vulgaris l.) Seedlings under metal stress

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The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes

Cited by 105 publications

References 40 publications

Vitamins C, E, and NADH on &lt;i&gt;in Vitro&lt;/i&gt; Lymphocyte Proliferation and Redox Status among Obese Patients

Vitamins C, E, and NADH on &lt;i&gt;in Vitro&lt;/i&gt; Lymphocyte Proliferation and Redox Status among Obese Patients

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Physiological behavior of bean (phaseolus vulgaris l.) Seedlings under metal stress

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Product

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The antioxidant effects of vitamin A, C, and E on aflatoxin B₁-induced oxidative stress in human lymphocytes

Vitamins C, E, and NADH on <i>in Vitro</i> Lymphocyte Proliferation and Redox Status among Obese Patients

Vitamins C, E, and NADH on <i>in Vitro</i> Lymphocyte Proliferation and Redox Status among Obese Patients