The antioxidant properties of serum albumin

Roche, Marjolaine; Rondeau, Philippe; Singh, Nihar Ranjan; Tarnus, Evelyne; Bourdon, Emmanuel

doi:10.1016/j.febslet.2008.04.057

Cited by 1,000 publications

(770 citation statements)

References 65 publications

Supporting

Mentioning

730

Contrasting

Unclassified

Order By: Relevance

“…Albumin is a wellknown antioxidant [23]. The intrinsic capacity of albumin to protect erythrocytes from free radical-induced hemolysis was evidenced by a higher hemolysis half-time (HT 50 ) for IncBSA (+ 47.3% vs. MES, p b 0.05) (Fig.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Deciphering metal-induced oxidative damages on glycated albumin structure and function

Baraka-Vidot¹,

Navarra

Leone

et al. 2014

Biochimica et Biophysica Acta (BBA) - General Subjects

Self Cite

View full text Add to dashboard Cite

Background: Metal ions such as copper or zinc are involved in the development of neurodegenerative pathologies and metabolic diseases such as diabetes mellitus. Albumin structure and functions are impaired following metaland glucose-mediated oxidative alterations. The aim of this study was to elucidate effects of Cu(II) and Zn(II) ions on glucose-induced modifications in albumin by focusing on glycation, aggregation, oxidation and functional aspects. Methods: Aggregation and conformational changes in albumin were monitored by spectroscopy, fluorescence and microscopy techniques. Biochemical assays such as carbonyl, thiol groups, albumin-bound Cu, fructosamine and amine group measurements were used. Cellular assays were used to gain functional information concerning antioxidant activity of oxidized albumins. Results: Both metals promoted inhibition of albumin glycation associated with an enhanced aggregation and oxidation process. Metal ions gave rise to the formation of β-amyloid type aggregates in albumin exhibiting impaired antioxidant properties and toxic activity to murine microglia cells (BV2). The differential efficiency of both metal ions to inhibit albumin glycation, to promote aggregation and to affect cellular physiology is compared. Conclusions and general significance: Considering the key role of oxidized protein in pathology complications, glycation-mediated and metal ion-induced impairment of albumin properties might be important parameters to be followed and fought.

show abstract

Section: Resultsmentioning

confidence: 99%

“…This plasma protein could serve as a circulating depot for many drugs and also metal ions [21,22]. In parallel, albumin is sustainably and continually exposed to oxidative stresses impairing its beneficial properties [23].…”

Section: Introductionmentioning

confidence: 99%

Deciphering metal-induced oxidative damages on glycated albumin structure and function

Baraka-Vidot¹,

Navarra

Leone

et al. 2014

Biochimica et Biophysica Acta (BBA) - General Subjects

Self Cite

View full text Add to dashboard Cite

show abstract

“…Low serum albumin levels are associated with increased risk of HF onset and progression. Indeed, hypoalbuminemia may promote pulmonary congestion (according to Starling's law),6 myocardial edema and subsequently worsening of myocardial dysfunction,7 diuretic resistance and fluid retention,8 and a decrease in antioxidant functions and anti‐inflammatory properties 9…”

Section: Introductionmentioning

confidence: 99%

Serum albumin level and hospital mortality in acute non‐ischemic heart failure

et al. 2017

View full text Add to dashboard Cite

AimsHypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of hospital mortality in patients admitted for acute non‐ischemic HF.Methods and resultsWe examined the association between albumin and hospital mortality in a cohort of 546 patients admitted for acute non‐ischemic HF. None of the patients had infectious disease, severe arrhythmias (atrial fibrillation, ventricular tachycardia, ventricular fibrillation), required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Thirty‐six patients (7%) died during the hospital stay. These patients were significantly older (78 ± 9 vs. 72 ± 12 years; P = 0.006), had higher heart rate (P < 0.0001), increased creatinine level (P = 0.01), lower systolic and diastolic blood pressures (P < 0.05), elevated leucocyte count (P = 0.001), and lower albumin levels (31.3 ± 5.6 g/L vs. 36.9 ± 4.1 g/L; P < 0.001). With multivariable analysis, age (P = 0.01), heart rate (P < 0.0003), diastolic blood pressure (P < 0.01), leukocyte count (P = 0.009), and serum albumin level (P < 0.0001) emerged as independent predictors of hospital mortality. Hypoalbuminemia (<34 g/L) yielded the best sensitivity (78.8%) and specificity (75%) for predicting hospital death.ConclusionsSerum albumin level measured at admission can serve as a simple prognostic factor in acute non‐ischemic HF. Hypoalbuminemia is associated with increased risk of hospital mortality, especially in elderly patients.

show abstract

“…These non-enzymatic antioxidants protect cells from harmful effects of free radicals by capturing them within cells [3]. Albumin is found in the circulatory system, abundantly [4]. It has a 66 kDa of molecular weight and carries fatty acids, cholesterol, bile pigments, and drugs in the organism.…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in haptoglobin phenotypes, some non-enzymatic antioxidants and electrophoretic profiles of serum proteins in rats

Çiftçi

Yarım²,

Çenesiz³

et al. 2012

Turk J Bioch

View full text Add to dashboard Cite

Aim: Determination of age-related changes in levels of some non-enzymatic antioxidants such as serum haptoglobin, haemoglobin and albumin, serum haptoglobin phenotype and serum protein profile was aimed with this study. Methods and results: Fifty Sprague-Dawley male rats were divided equally into five groups as 1 (one-month old), 2 (six-months old), 3 (twelve-months old), 4 (eighteen-months old) and 5 (twenty-four-months old). The serum protein concentrations were measured by autoanalyzer. A decrease was determined in the concentrations of the total protein and albumin related to age. However, no clear decrease in the serum globulin concentrations occurred. Serum haptoglobin concentrations were measured by ELISA and an increase was detected with age. Serum haemoglobin concentrations were increased up to 3 months old, but decreased from 3 to 24 months old of age. The electrophoretic profiles of serum total protein were determined by native-PAGE. No differences were observed in total serum profiles between age groups. To determine serum haptoglobin profiles, western blot was performed and haptoglobin patterns were designated as "aa" (single band) or "ab" (two bands) patterns. The "ab" pattern was more frequently observed in older rats. Also, 15 protein bands ranged between 19 to 244 kDa, were detected by SDS-PAGE. After SDS-PAGE, western blot were performed and three haptoglobin bands (10, 37 and 47 kDa) were detected. Conclusion:The age-related changes in total serum protein, albumin, haemoglobin and haptoglobin concentrations as well as the prevalent haptoglobin phenotypes may be considered as indicators in some age-related diseases.

show abstract

The antioxidant properties of serum albumin

Cited by 1,000 publications

References 65 publications

Deciphering metal-induced oxidative damages on glycated albumin structure and function

Deciphering metal-induced oxidative damages on glycated albumin structure and function

Serum albumin level and hospital mortality in acute non‐ischemic heart failure

Age-related changes in haptoglobin phenotypes, some non-enzymatic antioxidants and electrophoretic profiles of serum proteins in rats

Contact Info

Product

Resources

About