The Antiparasitic Activity of Nicarbazin

Cuckler, A. C.; Malanga, C. M.; Ott, Walther H.

doi:10.3382/ps.0350098

Cited by 48 publications

(17 citation statements)

References 6 publications

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“…These results are in agreement with those of Bar-ber (1955), Cuckler, Malanga and Ott (1956), Marthedal and Veiling (1957), and McLoughlin, Rubin and Cordray (1957). Furthermore, the total weight gain per group was greater in the medicated than in the unmedicated birds in experiments B and C. Similar results were obtained by McLoughlin, Rubin and Cordray (1957) when the initial inoculation was 50,000 oocysts.…”

Section: Discussionsupporting

confidence: 94%

“…33: -1146 N ICARBAZIN has been reported to be an efficient prophylactic agent for the control of cecal coccidiosis in chickens by Barber (1955), Ott, Kuna, Porter, Cuckler and Fogg (1955), Rubin, Mc-Loughlin, Costello and Wehr (1956), and others. Furthermore, Barber (1955), Cuckler, Malanga and Ott (1956), , Marthedal and Veiling (1957), and McLoughlin, Rubin and Cordray (1957) have reported that this drug does not interfere with the development of immunity under the experimental conditions described. The data herein, which deal with a range in size of immunizing infections, substantiate and augment the earlier findings.…”

mentioning

confidence: 91%

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Further Studies on the Development of Immunity to Cecal Coccidiosis in the Presence of Nicarbazin

1958

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Section: Discussionsupporting

confidence: 94%

mentioning

confidence: 91%

Further Studies on the Development of Immunity to Cecal Coccidiosis in the Presence of Nicarbazin

1958

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“…The birds in the remaining five pens were not vaccinated but were treated throughout life with the anticoccidial agent nicarbazin, nominally at 125 ppm: analysis of samples of each batch of food used during the trial gave an actual range of 100-120 ppm. Nicarbazin, a non-ionophore, was chosen both for its good efficacy, which controlled any possible crosscontamination with oocysts from vaccinated birds, and its lack of toxicity at 125 ppm (Cuckler et al, 1956;Lucas, 1958). Furthermore, unlike ionophores, it has no antibacterial activity that might improve food conversion.…”

Section: Methodsmentioning

confidence: 99%

Safety of the attenuated anticoccidial vaccine ‘Paracox’ in broiler chickens isolated from extraneous coccidial infection

Rb¹

1994

Vet Res Commun

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A trial was carried out in 1-day-old broiler chicks raised for 54 days in floorpens under simulated commercial conditions, but isolated from all extraneous virulent coccidial infections, to demonstrate the safety of 'Paracox' attenuated vaccine administered at the recommended dose when chicks were 7 days old. The vaccine did not adversely affect the water consumption, faecal moisture or litter condition of the broilers. Recycling of the attenuated coccidia occurred in vaccinated birds, oocysts being present in the litter between 5 and 33 days after vaccination; a single peak of oocysts was detectable 5 or 12 days after vaccination. Unvaccinated medicated control birds did not produce oocysts, indicating freedom from both between-pen contamination by the vaccine and invasion of the chicken-house by extraneous coccidial infection. A small proportion (4%) of vaccinated birds had mild coccidial lesions when sampled at 26, 33 or 40 days after vaccination. Despite this, the vaccinated birds performed better than control (unvaccinated, nicarbazin-treated) birds and there was no post-vaccinal check in their weight gain. Their mean finishing weight was 10.4% greater, their food conversion ratio 7.2% lower and their mortality 44.4% lower than the unvaccinated control birds, reflecting the safety of 'Paracox' vaccine.

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“…There is debate in the literature regarding the passive versus active transport of organochlorine pesticides into and through the chorioallantoic membrane (13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Resultsmentioning

confidence: 99%

Determination of 4,4‘-Dinitrocarbanilide (DNC), a Component of Nicarbazin, in Canada Goose (Branta canadensis) Eggshells Using High-Performance Liquid Chromatography

Stahl

VerCauteren

Buettgenbach

et al. 2003

J. Agric. Food Chem.

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A method was developed using high-performance liquid chromatography to assay 4,4′-dinitrocarbanilide (DNC), the active ingredient in Nicarbazin, in eggshells collected from Canada geese fed a formulated feed fortified with Nicarbazin at doses of 0, 125, 250, and 500 µg/g. The method was developed using chicken eggshells fortified with DNC. The method was used to quantify DNC in both the shell-associated membranes and the calcified shell extracellular matrix. These values were compared to those obtained for a composite sample consisting of both the membranes and the calcified shell extracellular matrix. The validated method was used to quantify DNC in eggshells from geese fed fortified feed to ascertain the effect of Nicarbazin feed concentration on shell DNC concentration. DNC levels in the eggshells were highly correlated with feed dose.

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The Antiparasitic Activity of Nicarbazin

Cited by 48 publications

References 6 publications

Further Studies on the Development of Immunity to Cecal Coccidiosis in the Presence of Nicarbazin

Further Studies on the Development of Immunity to Cecal Coccidiosis in the Presence of Nicarbazin

Safety of the attenuated anticoccidial vaccine ‘Paracox’ in broiler chickens isolated from extraneous coccidial infection

Determination of 4,4‘-Dinitrocarbanilide (DNC), a Component of Nicarbazin, in Canada Goose (Branta canadensis) Eggshells Using High-Performance Liquid Chromatography

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