“…Studies have examined the efficacy and benefits that SP may have for periodontal care and the mechanism of action through its anti-inflammatory [ 493 , 495 , 496 ], antioxidant [ 494 , 495 , 496 , 497 , 498 ], and antibacterial effects [ 493 , 499 , 500 ], as well as the regenerative modulatory activity it has. SP’s clinical therapeutic impact on periodontal health and inflammation ( Table 1 and Table 2 ) has been reviewed [ 192 , 193 , 194 , 195 , 501 , 502 , 503 , 504 , 505 , 506 , 507 , 508 , 509 ]. All trials that employed SP ( Table 1 ) showed a substantial decrease in gingival inflammation and plaque buildup, suggesting the effectiveness of SP herbal supplementary treatment in treating or preventing inflammation and plaque, which are significant contributors to periodontal diseases [ 510 ].…”