The antitumor activity of the S-nitrosoglutathione and dinitrosyl iron complex with glutathione: Comparative studies

Antitumour Activity of Dinitrosyl Iron Complexes with Thiol-Containing Ligands in Animals: An Overview

“…Similar results illustrating antitumour activities of B-DNIC and GS-NO were obtained in experiments with transplanted adenocarcinoma Ca-755 [56] (Figure 7e,7f). These data suggest that in contrast to non-malignant endometrial tumours (EMT) whose growth was fully suppressed by i/р treatment of rats with 10-fold daily doses of B-DNIC with glutathione (10−12 µmoles/kg) [51][52][53], in mice treated with much higher doses of B-DNIC (100−200 µmoles/kg) short-term (7−11 days) discontinuation of tumour growth was followed by a relapse, the rate of this process exceeding control values (Figure 7).…”

“…The rate of tumour growth in animals treated with 100 moles/kg of B-DNIC was steadily decreasing during the first 14 days of treatment and reached the control level (data not shown) [54]. The average lifespan in the experimental group exceeded control by 30% irrespective of the treatment mode (s/c or i/p) [55,56].…”

“…Our model study of solid Lewis carcinoma induced by treatment (intraperitoneal or subcutaneous) of mice with B-DNIC with glutathione was the first step in this direction. Such treatment significantly retarded the growth of transplanted subcutaneous tumours, however, only at the initial stages after which the malignant process recommenced (Figure 6a−6c) [54][55][56].…”

“…The discovery made in 2016 by a group of Taiwanese investigators headed by Prof. W-F. Liaw [104] helped us overcome the deadlock of our failures in 2014−2015 [54][55][56]. These authors succeeded in demonstrating a potent antitumour effect of water-soluble М-DNIC where the role of thiol-containing ligands was played by the mercaptoethanol derivatives (S(CH 2 ) 2 OH) and (S(CH 2 ) 2 NH 3 ).…”