The antitumour activity of a series of benzothiophenes

Hellmann, K.; Marshall, Philip Guy; Stayt, Susan

doi:10.1016/0006-2952(67)90081-0

Cited by 13 publications

(2 citation statements)

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“…Benzothiophene is an important sulfur‐containing heterocyclic compound that is widely used as a building block for the synthesis of larger, usually bioactive structures 1. Its substituted derivatives occupy a unique place in medicinal chemistry because they have promising antibacterial, antifungal and antitumour activities 2. Raloxifene,3 zileuton4 and sertaconazole5 are examples of commercial drugs containing a benzothiophene core (Scheme ).…”

Section: Methodsmentioning

confidence: 99%

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H₂O₂ by SECM

et al. 2015

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The present work describes the development of a selective, sensitive and stable sensing microsensor for scanning electrochemical microscopy (SECM) to measure H2O2 during electrochemical reduction of oxygen. The microsensor is based on graphene and Poly(3,4‐ethylenedioxythiophene) composite as support to iron (III) hexacyanoferrate (II) (PEDOT/graphene/FeIII4[FeII(CN)6]3 microsensor). The electrochemical properties of the PEDOT/graphene/FeIII4[FeII(CN)6]3 microsensor were investigated by cyclic voltammetry (CV) and scanning electrochemical microscopy (SECM). The PEDOT/graphene/FeIII4[FeII(CN)6]3 microsensor showed an excellent electrocatalytic activity toward hydrogen peroxide (H2O2) reduction with a diminution of the overpotential of about 500 mV in comparison to the process at a bare gold microelectrode. The microsensor presented excellent performance for two dimensional mapping of H2O2 by SECM in 0.1 mol L−1 phosphate buffer solution (pH 7.0). Under optimized conditions, a linear response range from 1 up to 1000 µmol L−1 was obtained with a sensitivity of 0.08 nA L µmol−1 and limit of detection of 0.5 µmol L−1.

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Section: Methodsmentioning

confidence: 99%

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H₂O₂ by SECM

et al. 2015

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“…Methods of transplanting the tumour were those used routinely in the department of cancer chemotherapy of ihe I.C.R.F. (Hellmann, Marshall, and Stayt, 1967). Test mice received I.C.R.F.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Metastatic Spread by I.C.R.F. 159: Selective Deletion of a Malignant Characteristic

Salsbury¹,

Burrage²,

Hellmann³

1970

BMJ

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Synergism of ICRF 159 and radiotherapy in treatment of experimental tumors

Hellmann

Murkin

1974

Cancer

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The antitumour activity of a series of benzothiophenes

Cited by 13 publications

References 4 publications

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H₂O₂ by SECM

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H₂O₂ by SECM

Inhibition of Metastatic Spread by I.C.R.F. 159: Selective Deletion of a Malignant Characteristic

Synergism of ICRF 159 and radiotherapy in treatment of experimental tumors

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The antitumour activity of a series of benzothiophenes

Cited by 13 publications

References 4 publications

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H2O2 by SECM

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H2O2 by SECM

Inhibition of Metastatic Spread by I.C.R.F. 159: Selective Deletion of a Malignant Characteristic

Synergism of ICRF 159 and radiotherapy in treatment of experimental tumors

Contact Info

Product

Resources

About

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H₂O₂ by SECM

High Sensitive Microsensor Based on Organic‐Inorganic Composite for Two‐Dimensional Mapping of H₂O₂ by SECM