The anxiolytic effect of salicylic acid is mediated via the GABAergic system in the fear potentiated plus maze behavior in rats

Extra virgin coconut oil (Cocos nucifera L.) intake shows neurobehavioural and intestinal health effects in obesity-induced rats

“…Furthermore, the main quantified phenolic compounds in E-VCO such as rutin, 3,4-dihydroxy benzoic acid (protocatechuic), salicylic acid and quercetin have demonstrated therapeutic action on neurobehavioural disorders, especially in depression and anxiety via modulation of serotonergic nervous system and monoamine neurotransmitter levels and gut–brain axis communication. 19–22 Phenolic compounds such as ferulic and p -coumaric acid also present in E-VCO can exert antioxidant, anti-apoptotic and neuroprotective effects. 63,64…”

“…Food & Function chuic), salicylic acid and quercetin have demonstrated therapeutic action on neurobehavioural disorders, especially in depression and anxiety via modulation of serotonergic nervous system and monoamine neurotransmitter levels and gut-brain axis communication. [19][20][21][22] Phenolic compounds such as ferulic and p-coumaric acid also present in E-VCO can exert antioxidant, anti-apoptotic and neuroprotective effects. 63,64 Thus, phenolic compounds and MCFA present in E-VCO may also have a potential effect on the modulation of the intestinal microbiota and induce an antidepressant effect.…”

“…15,16 These compounds, especially MCFA and phenolics, have shown neuroprotective and neurobehavioural effects, in addition to actions on intestinal health through different mechanisms of action. [17][18][19][20][21] MCFA are the majority fatty acids in E-VCO; they are composed of 6 to 12 carbons arranged in a straight chain, such as caprylic acid (also known as octanoic acid; C8), capric acid (decanoic acid; C10) and lauric acid. 22 MCFA are rapidly metabolized by the liver into energy in the form of ketones, which are then transported to the brain for energy supply.…”

“…15,16 These compounds, especially MCFA and phenolics, have shown neuroprotective and neurobehavioural effects, in addition to actions on intestinal health through different mechanisms of action. 17–21…”

The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice

“…The hippocampus was one of several limbic brain structures related to emotional disorder, with its dorsal section mainly involved in cognition and learning, while the ventral section mainly involved in emotional responses [23][24][25][26][27], especially depression [28,29], as the neurogenesis in the ventral DG of the hippocampus was signi cantly reduced in depressed mice [30,31]. Moreover, it was reported that activating neurons without changing the number of neurogenesis could alleviate depression-like behaviors [32].…”