The Anxiolytic Effect of Two Oriental Herbal Drugs in Japan Attributed to Honokiol from Magnolia Bark

Kuribara, Hisashi; Kishi, Eiko; Hattori, Naoko; Okada, Minoru; Maruyama, Yūji

doi:10.1211/0022357001777432

Cited by 72 publications

(37 citation statements)

References 8 publications

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“…administration, its serum half-life is >5 h, and its plasma concentration is similar to the concentration needed to induce in vitro cytotoxicity against breast cancer (36)(37)(38)(39). Moreover, HNK administration was well tolerated and no weight loss or other major side effects were observed in this and in previous other animal studies (13,19,37). Thus, HNK administration, at effective doses to treat breast cancer, seems to be safe and feasible.…”

Section: Discussionsupporting

confidence: 58%

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Wolf¹,

O’Kelly

Wakimoto

et al. 2007

Int J Oncol

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Abstract. Honokiol (HNK), a naturally occurring biphenyl, possesses potent antineoplastic and antiangiogenic properties. We investigated the in vitro and in vivo activity of HNK against breast cancer. HNK exhibited potent anti-proliferative activity against breast cancer cell lines and enhanced the activity of other drugs used for the treatment of breast cancer. In vivo, HNK was highly effective against breast cancer in nude mice. We identified two different effects of HNK on breast cancer cells: cell cycle inhibition, observed at lower doses of HNK, and induction of apoptosis, observed at higher doses of the compound. Our data suggest that HNK is a systemically available, non-toxic inhibitor of breast cancer growth and should be examined for clinical applications.

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Section: Discussionsupporting

confidence: 58%

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Wolf¹,

O’Kelly

Wakimoto

et al. 2007

Int J Oncol

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“…Both lignans increased ChAT activity and inhibited AChE activity in vitro, and increased hippocampal ACh release in vivo [78]. Honokiol and magnolol show anxiolytic effects [79] and these appear to be due to their ability to potentiate GABAergic neurotransmission [80]. These two compounds also appear to have antioxidant antiinflammatory and neuroprotective properties and such polyvalency in activity is of interest in their potential use in treating AD [81,82].…”

Section: /Howesmentioning

confidence: 99%

Natural Products and Derivatives Affecting Neurotransmission Relevant to Alzheimer’s and Parkinson’s Disease

2005

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The two major neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterised by low levels in the brain of the neurotransmitters acetylcholine (ACh) and dopamine (DA), respectively. Clinical treatment of these two conditions is palliative and relies, in most cases, on improving stimulation at the relevant receptors by either increasing levels of the endogenous neurotransmitter or by the use of substances which have a similar agonist response. Natural products continue to provide useful drugs in their own right but also provide templates for the development of other compounds. The major advances in the treatment of AD have been the use of acetylcholinesterase inhibitors such as galantamine, huperzine A, physostigmine and its derivatives to increase the levels of ACh rather than the use of cholinergic compounds, although compounds with nicotinic properties have attracted some interest. In contrast, the treatment of PD has relied on the elevation of DA levels by use of L-DOPA, its precursor, and by the administration of dopaminergic agonists, especially the ergot alkaloid derivatives. The use of inhibitors of enzymes that cause breakdown of DA is an avenue which is being explored. As well as the major natural products of clinical interest, the paper discusses the chemistry, activity and usage of the constituents of plants used in traditional medicine for the treatment of diseases presenting symptoms similar to those characteristic for Alzheimer’s or Parkinson’s disease.

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“…Du point de vue pharmacologique, Sb-to potentialise la baisse de libération d'acétylcholine induite par le diazépam. Les préparations Hk-to ou Sb-to, dont a retiré le magnolia, n'ont pas d'activité anxiolytique [13]. L'effet anxiolytique du honokiol est supérieur à celui du magnolol.…”

Section: Plantes De La Médecine Kampounclassified

Traitement du stress, de la somatothérapie aux plantes agissant sur le système limbique

Goetz

2007

Phytothérapie

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Dans cet article de synthèse, nous rapprochons la somatothérapie, une psychothérapie qui passe par le corps, et des plantes dont les préparations sont à même de traiter les conséquences du stress. Les deux méthodes, somatothérapie et phytothérapie, fonctionnent par les structures du système limbique en agissant en particulier sur les zones cérébrales où siègent les mécanismes émotionnels. Nous avons mis l'accent sur certaines préparations sinojaponaises qui agissent sur ces centres. Dans ces pré-parations apparaissent des drogues comme le magnolia, la réglisse ou encore le jujubier. Mots clés : Somatothérapie -Phytothérapie -Système limbique -Médecine kampo -Magnolia -JujubierRéglisseTreating stress: from somatotherapy to herbs that act on the limbic system Abstract: This review establishes links between somatotherapy-a method of psychotherapy using physical methods-and herbal preparations that treat the effects of stress. The two methods, somatotherapy and herbal medicine, function through the structures of the limbic system, most notably the areas of the brain where the mechanisms involved in emotions are located. We emphasize certain Chinese and Japanese preparations that act on these brain centres. The preparations include drugs such as magnolia, liquorice and jujube.

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The Anxiolytic Effect of Two Oriental Herbal Drugs in Japan Attributed to Honokiol from Magnolia Bark

Cited by 72 publications

References 8 publications

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Natural Products and Derivatives Affecting Neurotransmission Relevant to Alzheimer’s and Parkinson’s Disease

Traitement du stress, de la somatothérapie aux plantes agissant sur le système limbique

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