2022
DOI: 10.1016/j.ejphar.2022.175353
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The apelin/APJ signaling system and cytoprotection: Role of its cross-talk with kappa opioid receptor

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Cited by 9 publications
(3 citation statements)
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“…It may be related to the type of pain, dose, type of animal, route of administration, and time of injection in the animal models. The main molecular mechanisms underlying apelin/APLNR-induced pain are related to opioid receptors, γ-aminobutyric acid receptors, and the ERK pathway 37 . Here we found that long-term injection of morphine in mice leads to the morphine metabolite M3G accumulation, which activates ERK1/2 via APLNR and ultimately activates the release of microglia and inflammatory factors TNF-α, IL-1β, and IL-17, exacerbating NCP.…”
Section: Discussionmentioning
confidence: 99%
“…It may be related to the type of pain, dose, type of animal, route of administration, and time of injection in the animal models. The main molecular mechanisms underlying apelin/APLNR-induced pain are related to opioid receptors, γ-aminobutyric acid receptors, and the ERK pathway 37 . Here we found that long-term injection of morphine in mice leads to the morphine metabolite M3G accumulation, which activates ERK1/2 via APLNR and ultimately activates the release of microglia and inflammatory factors TNF-α, IL-1β, and IL-17, exacerbating NCP.…”
Section: Discussionmentioning
confidence: 99%
“…Apelin is a multifunctional regulatory peptide with potential cytoprotective properties. It is a ligand of the angiotensin II protein J receptor (APJ) receptor and belongs to the G protein-coupled receptor family [158]. Apelin mRNA is widely expressed in tissues such as the cardiovascular, central nervous, adipose, skeletal muscles, and gastrointestinal systems.…”
Section: Apelinmentioning
confidence: 99%
“…Several physiological processes, such as vasodilation, lipogenesis inhibition, suppression of cell signal transmission, etc. [50], are regulated by apelin. Some apelin subtypes cause the generation of NO, which leads to vasodilatation [51].…”
Section: Preclinical Studiesmentioning
confidence: 99%