The apoptotic effect of Ferulic acid-synthesized gold nanoparticles against human epidermoid carcinoma (A431) cells via activation of caspase-3 pathway

Rajendran, Indra; Ponrasu, Thangavel; Rajaram, Rama; Suguna, Lonchin

doi:10.1016/j.jddst.2021.102478

Cited by 14 publications

(8 citation statements)

References 57 publications

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“…It is a known fact that the apoptosis is followed by both pathways (intrinsic and extrinsic) (Rajendran et al, 2021) that led to the planned death of the cells. The cytochrome C is a key protein that attach to Apaf-1 (Bock & Tait, 2020) that is released when a cell dies through the intrinsic pathway.…”

Section: Discussionmentioning

confidence: 99%

De Novo Gold Nanoparticles Activate P53 by Inhibiting NF-Kb Signalling in Breast Cancer Cells

Safdar¹,

Özaslan²

2022

EPSTEM

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The aim of this study was to make de novo gold nanoparticles (Au(0)NPs) that turn on p53 and turn off NF-kB signaling in SKBR3 breast cancer cells. The chemical method was used to make the erythromycin-based Au(0)NPs. Authentic techniques were used to figure out what these Au(0)NPs were like. In the end, relative gene expression studies were used to treat SKBR3 breast cancer cells with these Au(0)NPs as a nanomedicine. When Au(0)NPs were present, the levels of caspases 3, 8, and 9 changed, p53 was turned on, and NF-kB was turned off at the same time. Compared to normal breast cells, the number of breast cancer cells (SKBR3) that could live was cut down (CRL-4010). Gene expressions of caspases also showed that the data were correct. When AuNPs were used to treat breast cancer cells, it was found that p53 and NF-kB had the opposite relationship. The study laid out a first step for using newly made AuNPs as a chemotherapeutic agent to treat SKBR3 cells.

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Section: Discussionmentioning

confidence: 99%

De Novo Gold Nanoparticles Activate P53 by Inhibiting NF-Kb Signalling in Breast Cancer Cells

Safdar¹,

Özaslan²

2022

EPSTEM

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“…In addition, cell-dependent cytotoxicity is a particular characteristic of nanomaterials, which has been earlier reported for HT29 and HeLa [19], MCF-7 [20], and A459 [21] cancer cells. The programmed cell death occurred via apoptosis as indicated by the intrinsic and extrinsic pathways [22]. The cell death via intrinsic pathway involves the secretion of cytochrome C that binds to apoptosis peptidase activating factor 1 (Apaf-1) [23].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and anticancer activity of a novel synthesized tet-AuNPs simultaneously activates p53 and inhibits NF-kB signaling in SKBR3 cell line

Safdar

Özaslan

Junejo

et al. 2021

Toxicol. Environ. Health Sci.

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Objective The objective of this study was to synthesize novel gold nanoparticles (Au(0)NPs) that simultaneously activates p53 and inhibits NF-kB signaling in SKBR3 breast cancer cells. Methods The tetracycline-based Au(0)NPs were synthesized by chemical method. These Au(0)NPs were characterized by different authentic techniques. The first characterization technique was UV-Visible (UV-Vis) spectroscopy to monitor Plasmon absorption maxima at 529 nm. The second technique was X-ray powder diffraction (XRD) pattern to confirm the crystalline nature of the prepared the Au(0)NPs. Finally, the Fourier transformed infra-red (FT-IR) spectroscopy was used to study the bonding patterns of the prepared the prepared Au(0)NPs with a size range of 10-50 nm. These Au(0)NPs were used as a nanomedicine to treat SKBR3 breast cancer cells using relative gene and protein expression studies. Results In response to Au(0)NPs, the level of caspases (3, 8 and 9) were changed, p53 was activated and NF-κB was inhibited simultaneously. The viability and proliferation of breast cancer cells (SKBR3) were downregulated as compared to the normal breast cells (CRL-4010). In addition, the gene and protein expressions of caspases supported the data. The inverse relationship between p53 and NFκB was found in AuNPs treated breast cancer cells. Conclusions The study laid down a preliminary step to employ newly synthesized AuNPs as a chemotherapeutic agent that stimulated cell death via both intrinsic and extrinsic apoptosis and inhibited the cell survival via suppressing the NFκB and recommended to have better insight.

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“…Rajendran et al [ 107 ] utilized ferulic acid (fa), a polyphenol, to increase the AuNPs stability. Thus, it operated as a reducing factor when combined with hydrogen tetrachloroaurate (III) hydrate at environment temperature.…”

Section: Nanotechnology (Metallic and Related Nps) Are Significant To...mentioning

confidence: 99%

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Marzi

Osanloo

Vakil

et al. 2022

BioMed Research International

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Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy.

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The apoptotic effect of Ferulic acid-synthesized gold nanoparticles against human epidermoid carcinoma (A431) cells via activation of caspase-3 pathway

Cited by 14 publications

References 57 publications

De Novo Gold Nanoparticles Activate P53 by Inhibiting NF-Kb Signalling in Breast Cancer Cells

De Novo Gold Nanoparticles Activate P53 by Inhibiting NF-Kb Signalling in Breast Cancer Cells

Cytotoxic and anticancer activity of a novel synthesized tet-AuNPs simultaneously activates p53 and inhibits NF-kB signaling in SKBR3 cell line

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

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