THE APPEARANCE OF GANGLIOSIDE DURING EMBRYOLOGICAL DEVELOPMENT OF THE FROG<sup>1</sup>

Yiamouyiannis, J. A.; Dain, Joel A.

doi:10.1111/j.1471-4159.1968.tb08966.x

Cited by 27 publications

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“…It was likewise assumed that the functions were introduced with some order during the evolution. The first surveys of interspecies differences described a great variation in quantity and pattern of gangliosides in vertebrates [14,15], particularly between different species of fish [16]. The most pronounced differences were in the quantity of lipid bound sialic acid per gram of fresh tissue between lower and higher vertebrates.…”

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The quest for the ganglioside functions; what did we learn more from «evo-devo» or signaling of long-term maintenance?

et al. 2010

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Gangliosides are characteristic extracellular-facing plasma membrane determinants in vertebrate brain. The four major gangliosides (GM1, GD1a, GD1b and GT1b) dominate among more than one hundred glycolipid structures in nervous tissue. During brain development the expression of simple gangliosides shifts toward more complex ones, accompanied by a multiple increase in their total amount. The shift is precisely regulated and some specific structures represent well established neurodevelopmental milestones. From the evolutionary perspective, the ganglioside content in fish and amphibian brain is significantly lower than in mammalian brain, but the general variability is greater. More-polar structures, abundant in Antarctic fishes, are rare in higher vertebrates or expressed only in a narrow developmental frame. Reptiles, birds and mammals share identical common structures expressed in similar patterns with minor interspecies differences. On the contrary, fish and amphibian brains show significant interspecies differences in amount, structure and expression patterns. The initial assumption of evolutionary studies was that the variations in lipid content, particularly the glycolipid content, during temperature adaptations in ectothermic and hibernating heterothermic animals, represent an efficient molecular mechanism of the membrane function preservation. Studies of ordered lipid domains in the last decade verified the ganglioside-mediated regulation of membrane proteins (receptor kinases, neurotransmitter receptors and ion channels) as well as receptor-ligand interaction important for cell signaling

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The quest for the ganglioside functions; what did we learn more from «evo-devo» or signaling of long-term maintenance?

et al. 2010

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“…This behaviour closely resembles that accurately described in the brain of human foetus (Vanier et al, 1971;Yusuf et al, 1977). It is interesting to observe that the ganglioside pattern in the early rabbit, and human, foetal brain, characterized by the abundance of multisialogangliosides, is somewhat similar to that occurring in adult brain of some fish and amphibian species (Yiamouyiannis and Dain, 1968;Avrova et al, 1979;Hilbig and Rahmann, 1980). It would be interesting to investigate extensively the possible links between brain phylogenesis and mammalian brain ontogenesis, with respect to ganglioside composition and content.…”

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confidence: 98%