The application of 18F-FDG PET/CT in ovarian immature teratomas when pathological examination results contradict clinical observations

Wang, Manni; Jiang, Shaoxiong; Zhang, Yiwen; Jiang, Chunhe; Xia, Fan; Lyu, Weiliang; Ma, Xuelei

doi:10.1097/md.0000000000009171

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…FDG-PET/CT is widely used for cancer staging and surveillance. FDG-avid lymph nodes, however, are not specific for malignancy [ 19 ]. Inflammatory cells avidly take up FDG when undergoing the energy-dependent process of activation.…”

Section: Discussionmentioning

confidence: 99%

Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review

et al. 2022

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Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic malignancy. We report a case of a 38 year old with mixed mature and immature teratomas who developed new peritoneal masses after adjuvant chemotherapy despite a normalization of tumor markers. In addition to low FDG uptake observed in these peritoneal masses, a PET scan showed hypermetabolic lymphadenopathy and pulmonary and spleen lesions suggesting widespread metastases. Subsequent surgical resection confirmed a mixed pathology with GTS and sarcoidosis. We reviewed the current literature evidence of GTS and sarcoidosis as a benign cause of lymphadenopathy in cancer patients. We emphasize the importance of a tissue diagnosis before instituting therapy for presumed cancer recurrence to avoid potentially fatal diagnostic traps and management errors. A multiple disciplinary team approach is imperative in managing patients with suspected recurrent immature teratomas.

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Section: Discussionmentioning

confidence: 99%

Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review

et al. 2022

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“…[ 1 – 3 ] However, elevated serum CA 19-9 has also been observed for some patients with either benign or malignant dermoid cysts. [ 4 – 9 ] It has also been reported that CA 19-9 staining is prominently noted around the apical cytoplasma of the epithelial lining. This phenomenon has led Atabekoglu et al to suggest that CA 19-9 is secreted into the cystic cavity.…”

Section: Discussionmentioning

confidence: 99%

Dermoid cyst with secretion of CA 19-9 detected by 18F-FDG PET/CT

2020

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Introduction: Carbohydrate antigen 19-9 (CA 19-9) is a tumor glycolipid, frequently elevated in the serum of patients due to malignancies from gastrointestinal organs; in particular, the pancreas. This carbohydrate antigen is also expressed in benign diseases. Patient concerns: A case of a 27-year-old female who has an unknown origin CA 19-9 elevation for 2 years. Diagnosis: After the left ovarian cystectomy and microscopic examination, the final diagnosis is a dermoid cyst. The dermoid cyst shows increased 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake in the 18 F-FDG positron emission tomography (PET)/computed tomography (CT) study. Intervention and outcomes: The laparoscopic oophorocystectomy was performed. It was observed that the patient's CA 19-9 level returned to normal after the surgery 6 months later. This showed that the dermoid cyst was responsible for the abnormal CA 19-9 level. Conclusion: In this case, we can learn that the 18 F-FDG PET/CT scan has potential use in patients with unknown origin of elevation CA 19-9.

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“…Foci of punctate fatty tissue and scattered calcifications in a solid ovarian mass on CT scan discriminate IT from MT (Figure 1). The combination of positron emission tomography (PET) and CT gives the additional benefit of providing morphologic and functional details in the case of IT [11].…”

Section: Review Clinical and Radiological Featuresmentioning

confidence: 99%

“…The combination of positron emission tomography (PET) and CT gives the additional benefit of providing morphologic and functional details in the case of IT [ 11 ].…”

Section: Reviewmentioning

confidence: 99%

Gliomatosis Peritonei and Its Relation to Teratoma: Role of Imaging and Histological Aspects

Patel¹,

Meena²

2022

Cureus

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Gliomatosis peritonei (GP) is a rare disease, usually associated with immature ovarian teratoma. GP may be rarely associated with mature ovarian teratoma. GP is composed of mature glial tissue elements, which histopathological examination can further confirm. Benign glial implants usually involve the omentum, peritoneum and lymph nodes. Many benign and malignant peritoneal diseases may mimic GP on clinical examination. GP may be confused with peritoneal carcinomatosis on computed tomography (CT) scan. A microscopic examination from peritoneal mass biopsy helps to rule out differential diagnosis. GP consists of mature glial tissue and is regarded as grade 0 according to the WHO grading of immature teratoma (IT). GP corresponds to a good prognosis with occasional cases showing malignant evolution.

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The application of 18F-FDG PET/CT in ovarian immature teratomas when pathological examination results contradict clinical observations

Cited by 13 publications

References 24 publications

Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review

Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review

Dermoid cyst with secretion of CA 19-9 detected by 18F-FDG PET/CT

Gliomatosis Peritonei and Its Relation to Teratoma: Role of Imaging and Histological Aspects

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