The application of an immunomodulator for the correction of the inflammatory process in periodontal tissues of the patients presenting with chronic generalized periodontitis

Sashkina, T. I.; Poryadin, G. V.; Runova, G. S.; Dubrovin, D. S.; Фасхутдинов, Д. К.; Markina, M. L.; Салдусова, И. В.; Sokolova, S I; Zaichenko, O. V.; Agaev, R. R.

doi:10.17116/rosstomat20169338-41

Ross. stomatol.

2016

DOI: 10.17116/rosstomat20169338-41

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The application of an immunomodulator for the correction of the inflammatory process in periodontal tissues of the patients presenting with chronic generalized periodontitis

T. I. Sashkina¹,

G. V. Poryadin²,

G. S. Runova³

et al.

Abstract: 1 Кафедра патологической физиологии и клинической патофизиологии (зав.-д.м.н., проф. Г.В. Порядин) лечебного факультета ГБоУ ВПо «российский научно-исследовательский университет им. н.И. Пирогова» Минздрава россии, Москва, россия; 2 кафедра пародонтологии (зав.-д.м.н., проф. о.о. янушевич) стоматологического факультета ГБоУ ВПо «Московский государственный медико-стоматологический университет им. а.И. евдокимова» Минздрава россии, Москва, россия; 3 кафедра хирургии полости рта (зав.-д.м.н., проф. Э.а. Базикян) … Show more

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Current opportunities and prospectives of immunotropic therapy in chronic generalized periodontitis

Antonov

Мудров²,

Nelyubin

et al. 2021

Med. immunol.

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Impairment of immunological reactivity in inflammatory periodontal diseases is well proven. To perform immunomodulatory treatment in domestic dental practice, various medications are used, including natural, chemically modified, recombinant, genetically engineered and synthetic substances, which differ in their effects upon innate and adaptive immune systems. Complex preparations of natural cytokines as well as genetically engineered preparations of IL-1, IL-2, growth factors, IFNα, IFNβ, IFNγ are applied in clinical settings. Clinical implementation of interferon and interferon inducers in combined therapy of generalized periodontitis is shown to increase resistance to viral components of the oral microbiota. Growth factors (platelet growth factor, fibroblast growth factor, endothelial growth factor, etc.) are successfully used for tissue regeneration in periodontics and maxillofacial surgery. Experimental studies have shown that local administration of toll-like receptor-9 and CD40 ligand may reduce periodontal ligature inflammation and bone loss in mice by inducing B-cell proliferation and increasing IL-10 mRNA expression. Promising results in development of new biologically active drugs are obtained with nanotechnology approaches, i.e., production of composite materials of metal nanoparticles with polymers, growth factors, and local application of these products. General limitations of all these growth factors include extremely short periods of biological activity, and adjusted duration of local effective concentrations. Therefore, it is important to develop a drug delivery system using appropriate scaffolding elements thus allowing local effects of the drug for a certain period of time. In experimental models, alginate hydrogels performed well upon local delivery of granulocyte-macrophage colony-stimulating factor and stromal lymphopoietin of the thymus. A new immunomodulatory strategy for alveolar bone regeneration targets macrophages. A biologically functionalized injectable microsphere of heparin-modified gelatin nanofibers that mimic the architecture of the natural bone extracellular matrix, and provide an osteoconductive microenvironment for bone cells includes IL-4, which has heparin-binding domains. These medications represent a component of a comprehensive treatment schedule, and should be evaluated for immune status before and after therapy. Thus, recent advances in studies of innate and acquired immune responses in inflammatory diseases and, in particular, in periodontal disorders, allows us to develop new approaches and methods of treatment in order to improve efficiency of complex therapy in the inflammatory periodontal diseases.

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Current opportunities and prospectives of immunotropic therapy in chronic generalized periodontitis

Antonov

Мудров²,

Nelyubin

et al. 2021

Med. immunol.

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Hirudotherapy in treatment of chronic generalised periodontitis

Sashkina

Abdullaeva

Runova

et al. 2019

BRSMU

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Chronic generalized periodontitis (CGP) is a disease associated with low susceptibility to the therapeutic protocols applied; practitioners tend to characterize it as a disease presenting certain difficulties. Therefore, the search for drugs and methods capable of increasing the efficacy of CGP therapy is an ongoing process. Additional problems, which have to do with either with antibiotic resistance or increased sensitivity to drugs, also occur quite often. This study aimed to assess the possibility of applying hirudotherapy in the context of conservative treatment of CGP. 50 patients with CGP without somatic pathology were examined and treated. The participants were divided into two groups (n = 25), all group members of about the same age. At the first stage, the treatment followed the accepted standard: professional oral hygiene procedures, antimicrobial and anti-inflammatory drugs, demonstration of proper personal oral hygiene routines. Then, first group went through a monthlong hirudotherapy course that consisted of 6 to 8 individual procedures. Second group was observed throughout this period with the aim to control the level of their compliance with the oral hygiene routines they were trained. Having analyzed the results, we found that hirudotherapy was more effective than what was prescribed to the second (control) group. The papillary marginal alveolar index (PMA), which reflects the severity of inflammation and gum bleeding, decreased significantly in the first group, where medicinal leeches were used: in the patients with severe CGP it went down by 6%, in those with moderately severe CGP the index decreased by 24% and the participants whose CGP was only light had the PMA go down by 2%. Thus, we have demonstrated the efficacy of hirudotherapy in the context of conservative CGP treatment, which allows recommending this method for inclusion into clinical practice.

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The application of an immunomodulator for the correction of the inflammatory process in periodontal tissues of the patients presenting with chronic generalized periodontitis

Cited by 2 publications

References 0 publications

Current opportunities and prospectives of immunotropic therapy in chronic generalized periodontitis

Current opportunities and prospectives of immunotropic therapy in chronic generalized periodontitis

Hirudotherapy in treatment of chronic generalised periodontitis

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