The Application of Beta-Tricalcium Phosphate in Implant Dentistry: A Systematic Evaluation of Clinical Studies

Abstract

The demand for synthetic graft materials in implant dentistry is rising. This systematic review aims to evaluate the survival rate of dental implants placed simultaneously with bone regeneration procedures using the material β-tricalcium phosphate, one of the most promising synthetic graft materials. The electronic search was conducted in PubMed, Scielo, and the Cochrane Central Register of Controlled Trials. There were five randomized clinical trials, one of which was a non-randomized controlled clinical trial and four of which were observational studies without a control group included. Implant survival rate and other clinical, radiographic, and histological parameters did not differ from those of implants placed simultaneously with another type of graft material, or placed in blood clots or natural alveolar ridges. Based on the available literature, β-tricalcium phosphate seems to be a promising graft material in implant dentistry. Nevertheless, more randomized clinical trials, with long follow-up periods, preoperative and postoperative CBCT, and histological analysis, are necessary to assess its long-term behavior.

Evaluation of the osteoconductive properties of scaffold containing platete-enriched-fibrin (PRF) with three calcium phosphate (TCP) in the alveolar socket repair after tooth extraction: An animal study

“…28 Biphasic calcium phosphates with different HA/β-TCP ratios, may improve the mechanical properties and maintain a good reabsorption capacity which is suggested to be used as an alteration for β-TCP alone in the highly loaded sites. 32…”

“…28 Biphasic calcium phosphates with different HA/β-TCP ratios, may improve the mechanical properties and maintain a good reabsorption capacity which is suggested to be used as an alteration for β-TCP alone in the highly loaded sites. 32 5. Finally, in vivo human studies for therapeutic purposes, elimination of ridge resorption and higher success rate for implant placement can be intended.…”

Bioactive Inorganic Materials for Dental Applications: A Narrative Review

“…It was being used as an absorbable material in the development of tissue engineering scaffolds [ 96 ]. β-TCP had found more uses in clinical applications comparatively, and was also used in developing monophasic/biphasic bioceramics [ 97 , 98 , 99 , 100 , 101 ]. However, composites containing α-TCP were common in repairing bone defects [ 60 , 102 ].…”

Combination of Carbonate Hydroxyapatite and Stem Cells from Human Deciduous Teeth Promotes Bone Regeneration by Enhancing BMP-2, VEGF and CD31 Expression in Immunodeficient Mice

“…Using a material with a composition similar to that of natural bone minerals is important for reducing inflammatory responses and achieving optimal resorption behavior [ 8 ]. Artificial bone materials such as hydroxyapatite and β-tricalcium phosphate composites (β-TCP) are applied in oral surgery and prosthodontic fields [ 9 , 10 ]. These inorganic materials have high affinity for osteoblasts but are difficult to clinically evaluate for bone regeneration because they are mostly non-resorbable or have long resorption times and are radiopaque.…”