The Application of Cell Survival Theory to High Dose-rate Intracavitary Therapy

Liversage, W. E.

doi:10.1259/0007-1285-39-461-338

Cited by 23 publications

(7 citation statements)

References 21 publications

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“…(4), (6) and (7)) offer a number of advantages over the NSD, TDF, and CRE type equations (Fowler, 1984). The fact that the same formalism is shown to be entirely consistent with the General Formula of Liversage (1969a) is an indication that it may well be of wider validity. A considerable degree of empiricism is associated with the other wellknown radiobiological models (Fowler, 1980) and it is better if clinical effects can be realistically interpreted in terms of a model employing only a few cellular parameters.…”

Section: Summary Of Useful Equationsmentioning

confidence: 84%

“…Equation (14) has been shown to be valid for two mammalian systems (Liversage, 1969a) and has been extensively and successfully tested for a non-mammalian system (Liversage & Dale, 1978). The value of n which has been found acceptable in these tests of the equation is 0.46 h " 1 (corresponding to a dose-equivalent repair half-life of 1.5 h), and this is a value frequently quoted in other literature.…”

Section: Protracted Irradiation At Constant Dose Ratementioning

confidence: 99%

“…Liversage used this information to compare the three main models for equating clinical radiation effects, i.e. the TDF (Orton & Ellis, 1974), CRE (Kirk et al, 1971) and Liversage (1969a) methods. In each case the ratio of predicted dose (at high dose-rate) to equivalent dose (from clinical experience) was evaluated.…”

Section: Application Of the Low Dose-rate Lq Equations To Establishedmentioning

confidence: 99%

“…The equation given by Liversage (1969a) also makes this assumption, since the dose correction to be made from one fractionated regime to another (a necessary step in problem solving with this equation), is based on the skin reaction data of Shuttleworth and Fowler (1966). Since acute skin reactions are not used in determining the clinical equivalence of intracavitary regimes, the figures in the first three columns of Table I indicate the likely errors involved when employing radiobiological models which are based on such effects.…”

Section: Application Of the Low Dose-rate Lq Equations To Establishedmentioning

confidence: 99%

“…Fraction numbers <17 will produce relatively more late-reacting tissue damage, as has already been demonstrated. Liversage (1966Liversage ( , 1969a has discussed these conditions of equivalence in some detail. The LQ equations enable an assessment to be made of the likely magnitude of changes in clinical responses for other, non-equivalent, conditions.…”

Section: Summary Of Useful Equationsmentioning

confidence: 99%

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The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy

Rg¹

1985

BJR

775

411

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The linear-quadratic (LQ) dose-effect formalism is currently providing new perspectives into the ways in which alterations in the dose per fraction in conventional radiotherapy may be used to bring about improved results with respect to early or late normal tissue reactions. In this paper, using a model initially developed by Roesch, the LQ equations are explored further in terms of dose-rate rather than dose. By the incorporation of one other parameter, mu, which relates to the rate of repair of sub-lethal radiation damage, a more general formalism is obtained. In particular, equations are derived which can be used to examine the relative effectiveness of different treatment regimes, including those involving decaying sources. Such equations are of wider applicability than other LQ derivations which relate only to dose-response relationships. The extended equations, which are fully consistent with the existing LQ method, are also shown to lead directly to other independently established, relationships for protracted irradiation. The nature of the link between high and low dose-rate treatments is discussed, and some worked examples provide indications of how the new equations may be used to assess further the potential clinical benefits of low dose-rate treatments and permanent implants.

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Section: Summary Of Useful Equationsmentioning

confidence: 84%

Section: Protracted Irradiation At Constant Dose Ratementioning

confidence: 99%

Section: Application Of the Low Dose-rate Lq Equations To Establishedmentioning

confidence: 99%

Section: Application Of the Low Dose-rate Lq Equations To Establishedmentioning

confidence: 99%

Section: Summary Of Useful Equationsmentioning

confidence: 99%

See 3 more Smart Citations

The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy

Rg¹

1985

BJR

775

411

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High-dose rate intracavitary radiation therapy for advanced head and neck tumors

Akanuma

1977

Cancer

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Fifty-seven treatments were performed on 27 head and neck pateints with recurrent or residual tumors on a high dose rate, remote controlled afterloading unit: There were 16 cases of maxillary sinus tumors, 6 epipharynx, 3 alveolar ridge, 1 hard palate and 1 floor of mouth. All patients have been followed up more than 2 years except one. Five patients are alive without local recurrence for more than 2 years. In 13 patients local tumors disappeared once and normal mucosa covered the tumor sites. Two patients died from local bleeding. In six patients this method failed to destroy tumors. Our prupose was palliative local control: therefore, in two-thirds of cases treated we were successful with this easy method of nonfractionated acute intracavitary radiation. This result is favorable, considering that all cases treated here were failures following full dose external radiation, although the treatment had to be repeated more than twice in 15 cases. Relief of symptoms is excellent when this therapy is used.

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Cancer of the Endometrium

Herbolsheimer

Rotte

1997

Radiation Oncology of Gynecological Cancers

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The Application of Cell Survival Theory to High Dose-rate Intracavitary Therapy

Cited by 23 publications

References 21 publications

The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy

The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy

High-dose rate intracavitary radiation therapy for advanced head and neck tumors

Cancer of the Endometrium

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