The application of CYFRA21-1 in cervical lesions screening in high-risk human papillomavirus infected women

Abstract

Objectives: To investigate the role of cytokeratin-19 fragment (CYFRA21-1) in cervical lesions screening in high-risk human papillomavirus (HR-HPV) infected women. Material and methods:The study was a retrospective study. First, the results of CYFRA21-1, cytology (TCT), and HR-HPV examinations of 1039 outpatients from gynecology department in Tumor Hospital Affiliated to Xinjiang Medical University were collected. Then, the data was analyzed using a series of statistical methods. Results:There was a correlation between CYFRA21-1 levels and HPV-DNA load in HR-HPV infected women (r s = 0.711, p = 0.015). CYFRA21-1 levels and positive rate increased along with deepening of cervical cell lesions. In HR-HPV infected women, there was a statistically significant difference (t = 6.022, p < 0.001) in CYFRA21-1 levels between the group with cytological lesions (4.87 ± 1.58 ng/mL) and the group with normal cytology (2.52 ± 0.96 ng/mL). Positive rates of CY-FRA21-1 in the two groups were 62.06% and 7.83%, respectively, and also exhibited statistically significant differences (χ 2 = 74.624, p < 0.001). When diagnosing cytological lesions via CYFRA21-1 in HR-HPV infected women, sensitivity was 62.07%, specificity was 92.17%, positive predictive value was 88.89%，negative predictive value was 70.67%. Compared to CYFRA21-1 negative women, cytological lesions were detected 19.273 times more often in CYFRA21-1 positive women. Conclusion:CYFRA21-1 could provide a reference idea for further diagnosis of women who are infected with HR-HPV but whose cytology is normal.

Genome-Wide Profiling of Human Papillomavirus DNA Integration into Human Genome and Its Influence on PD-L1 Expression in Chinese Uygur Cervical Cancer Women

“…Cervical cancer was one of the most common malignant tumors in China, in which its prevalence rate was 7th in all cancers and its mortality was 8th in all female cancers [1]. HPV infection is known as the main cause of cervical cancer; most of HPV infection could be cleaned by the host immune responses, but some persistent HPV infection would lead to the cytopathy of cervical cancer cells [2][3][4]. The previous studies found that the HPV persistent infection consisted of two phases: in the first phase of viral replication, HPV firstly infected basal cells of the cervix, bare virus DNA was the free state in the host cell nucleus.…”