The application of freeze-drying as a production method of drug nanocrystals and solid dispersions – A review

Jakubowska, Emilia; Lulek, Janina

doi:10.1016/j.jddst.2021.102357

Cited by 34 publications

(17 citation statements)

References 113 publications

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“…Nanoscale material and ultrafine powders have increasing applications, such as in environmental and sustainable areas, − drawing significant interests due to their large specific surface areas − and high reaction activities. − Freeze-drying technology has been often used to produce nanoparticles and ultrafine particles. − For the freeze-drying technology, the first step is a freezing process to freeze water with target molecules, particles, or materials inside. During the fast-freezing process, water in the aqueous solution is solidified in a short period, forming a network of ice crystals, also known as freeze-casting or ice templating.…”

Section: Introductionmentioning

confidence: 99%

Freeze-Dissolving Method: A Fast Green Technology for Producing Nanoparticles and Ultrafine Powder

Wang

Luo

et al. 2022

ACS Sustainable Chem. Eng.

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A new technology, a freeze-dissolving method, has been developed to isolate nanoparticles or ultrafine powder and is a more efficient and sustainable method than the traditional freeze-drying method. In this work, frozen spherical ice particles were produced with an aqueous solution of sodium bicarbonate or ammonium dihydrogen phosphate at various concentrations to generate nanoparticles of NaHCO 3 or (NH 4 )(H 2 PO 4 ). The freeze-drying method sublimates ice, and nanoparticles of NaHCO 3 or (NH 4 )(H 2 PO 4 ) in the ice templates remain. The freeze-dissolving method dissolves ice particles in a low freezing point solvent at temperatures below 0 °C, and then, nanoparticles of NaHCO 3 or (NH 4 )(H 2 PO 4 ) can be isolated after filtration. The freeze-dissolving method is 100 times faster with about 100 times less energy consumption than the freeze-drying method as demonstrated in this work with a much smaller facility footprint and produces the same quantity of nanoparticles with a more uniform size distribution.

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Section: Introductionmentioning

confidence: 99%

Freeze-Dissolving Method: A Fast Green Technology for Producing Nanoparticles and Ultrafine Powder

Wang

Luo

et al. 2022

ACS Sustainable Chem. Eng.

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“…However, since the amount of residual organic solvent can cause physiological effects, nowadays, the vial containing the crystalline ANF solid is directly reconstituted with water and then diluted with isotonic saline or glucose for infusion. To achieve the solubilization of ANF in solid parenteral formulations, freeze‐drying (lyophilization) process is applied to form lyophilized powder samples [73]. For this purpose, this new form is prepared by dispersing the compound in an aqueous solution of highly water‐soluble carrier materials such as gelatin, lysine, and sorbitol.…”

Section: Resultsmentioning

confidence: 99%

First Report for the Electrooxidation of Antifungal Anidulafungin: Application to its Voltammetric Determination in Parenteral Lyophilized Formulation Using a Boron‐doped Diamond Electrode in the Presence of Anionic Surfactant

Özok¹,

Allahverdiyeva

Yardım

et al. 2022

Electroanalysis

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In this paper, for the first time, the study of electrochemical oxidation and electroanalytical determination of anidulafungin (ANF), a semi‐synthetic echinocandin with antifungal activity was conducted. For this purpose, a commercially available boron‐doped diamond (BDD) electrode pretreated electrochemically (anodic and subsequent cathodic) was used. Employing cyclic voltammetry, the compound presented a single and irreversible oxidation step. The electrode process is controlled by a dual mechanism of diffusion and adsorption. A systematic study of various experimental conditions, such as the effect of electrode pretreatment, pH and the nature of the supporting electrolyte, surfactant, accumulation variables, and instrumental parameters on the adsorption behavior of ANF, was carried out by using square‐wave voltammetry. When the stripping mode (after 90 s accumulation at +0.3 V) was applied in 0.1 mol L−1 HNO3 containing 3×10−4 mol L−1 SDS, there was a linear dependence between the oxidation peak current at +1.29 V and the ANF concentration in the range from 0.1 to 10.0 μg mL−1 (8.8×10−8–8.8×10−6 mol L−1). The limit of detection value was found to be 0.021 μg mL−1 (1.8×10−8 mol L−1). Practical applicability of the proposed method was demonstrated in commercial parenteral dosage form.

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“…Therefore, it is extremely important to choose protective material types and control process parameters, such as temperature, time and the feed rate, during the entire process [ 110 ]. Freeze drying mainly includes three important steps: freezing, primary drying and secondary drying [ 111 ]. Compared with spray drying, the strain is protected from thermal damage and oxidative stress during freeze drying [ 112 , 113 ].…”

Section: Factors Affecting Probiotic Survivalmentioning

confidence: 99%

Characteristics of Probiotic Preparations and Their Applications

Wang

Chen

Xia

et al. 2022

Foods

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The probiotics market is one of the fastest growing segments of the food industry as there is growing scientific evidence of the positive health effects of probiotics on consumers. Currently, there are various forms of probiotic products and they can be categorized according to dosage form and the site of action. To increase the effectiveness of probiotic preparations, they need to be specifically designed so they can target different sites, such as the oral, upper respiratory or gastrointestinal tracts. Here we review the characteristics of different dosage forms of probiotics and discuss methods to improve their bioavailability in detail, in the hope that this article will provide a reference for the development of probiotic products.

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The application of freeze-drying as a production method of drug nanocrystals and solid dispersions – A review

Cited by 34 publications

References 113 publications

Freeze-Dissolving Method: A Fast Green Technology for Producing Nanoparticles and Ultrafine Powder

Freeze-Dissolving Method: A Fast Green Technology for Producing Nanoparticles and Ultrafine Powder

First Report for the Electrooxidation of Antifungal Anidulafungin: Application to its Voltammetric Determination in Parenteral Lyophilized Formulation Using a Boron‐doped Diamond Electrode in the Presence of Anionic Surfactant

Characteristics of Probiotic Preparations and Their Applications

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