The application of inductively coupled plasma mass spectrometry in pharmaceutical and biomedical analysis

Huang, Jinkun; Hu, Xin; Zhang, Junren; Li, Kexin; Yan, Ying; Xu, Xianbin

doi:10.1016/j.jpba.2005.11.014

Cited by 57 publications

(21 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike AAS, the multi-element capability of ICP-MS makes it particularly suitable to rapidly determine trace elements in biological samples. According to Parsons and Barbosa (2007) and Huang et al (2006), to date, ICP-MS has been recognized as a sensitive, efficient, and cost-effective approach to measuring the major, minor, and trace elements in clinical samples and increasing numbers of clinical laboratories are transitioning away from flame and electrothermal AAS methods to those based on ICP-MS.…”

Section: Atomic Spectrometric Detectionmentioning

confidence: 99%

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

Su¹,

Sun²,

Tzeng³

et al. 2009

Mass Spectrom. Rev.

View full text Add to dashboard Cite

The roles of metal ions to sustain normal function and to cause dysfunction of neurological systems have been confirmed by various studies. However, because of the lack of adequate analytical method to monitor the transfer kinetics of metal ions in the brain of a living animal, research on the physiopathological roles of metal ions in the CNS remains in its early stages and more analytical efforts are still needed. To explicitly model the possible links between metal ions and physiopathological alterations, it is essential to develop in vivo monitoring techniques that can bridge the gap between metalloneurochemistry and neurophysiopathology. Although inductively coupled plasma mass spectrometry (ICP-MS) is a very powerful technique for multiple trace element analyses, when dealing with chemically complex microdialysis samples, the detection capability is largely limited by instrumental sensitivity, selectivity, and contamination that arise from the experimental procedure. As a result, in recent years several high efficient and clean on-line sample pretreatment systems have been developed and combined with microdialysis and ICP-MS for the continuous and in vivo determination of the concentration-time profiles of metal ions in the extracellular space of rat brain. This article reviews the research relevant to the development of analytical techniques for the in vivo determination of dynamic variation in the concentration levels of metal ions in a living animal.

show abstract

Section: Atomic Spectrometric Detectionmentioning

confidence: 99%

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

Su¹,

Sun²,

Tzeng³

et al. 2009

Mass Spectrom. Rev.

View full text Add to dashboard Cite

show abstract

“…Recently, Haung et al have reviewed some of the applications of ICP-MS in pharmaceutical and biomedical analysis [27]. It was mainly focused on the introduction of ICP-MS in biomedical analysis including DNA, proteins, metabolites, biopharmaceuticals and traditional Chinese medicine.…”

Section: Detection Limitsmentioning

confidence: 99%

An overview of recent applications of inductively coupled plasma-mass spectrometry (ICP-MS) in determination of inorganic impurities in drugs and pharmaceuticals

Rao

Talluri

2007

Journal of Pharmaceutical and Biomedical Analysis

122

View full text Add to dashboard Cite

“…In general, ICP is one of the most important techniques contributing to the protection of human health because of its versatility [17]. It has increased researchers' interest in the field of biomedical monitoring activities [18].…”

Section: Introductionmentioning

confidence: 99%

Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

González‐Torres¹,

Torres²,

Torres³

et al. 2017

ChChT

View full text Add to dashboard Cite

Abstract.1 Cis-diaminedichloroplatinum(II), also known as cisplatin, has been quantified by use of inductivelycoupled plasma. We measured cisplatin indirectly by determining the platinum concentration in the samples. We focus on the determination of Pt from cisplatin in water. We demonstrate that the total concentration of the drug can be quantified through the content of platinum with acceptable linearity, precision, repeatability, accuracy, limit of detection and limit of quantification. Our method is applicable among others for monitoring quality of control samples for cisplatin regulatory submissions and for determination of the cisplatin release profiles in biomarker implants in vitro.

show abstract

The application of inductively coupled plasma mass spectrometry in pharmaceutical and biomedical analysis

Cited by 57 publications

References 73 publications

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

In vivomonitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques

An overview of recent applications of inductively coupled plasma-mass spectrometry (ICP-MS) in determination of inorganic impurities in drugs and pharmaceuticals

Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

Contact Info

Product

Resources

About