The application of micro reactors to synthetic chemistry

Haswell, Stephen J.; Middleton, Richard H.; O’Sullivan, Brian; Skelton, Victoria; Watts, Paul; Styring, Peter

doi:10.1039/b008496o

Cited by 235 publications

(128 citation statements)

References 47 publications

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“…On the other hand, several microfluidic applications call for spatially selective label-free detection, e. g. when molecules are separated in a microchannel by CE or when counting is required as in cell flow cytometry. In addition, spatially selective refractive index detection would enable multipoint sensing, e. g. for monitoring the reaction kinetics in chemical microreactors [99].…”

Section: Label-free Sensing With Mach-zehnder Interferometersmentioning

confidence: 99%

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Osellame

Hoekstra

Cerullo

et al. 2011

Laser & Photonics Reviews

290

226

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This paper provides an overview of the rather new field concerning the applications of femtosecond laser microstructuring of glass to optofluidics. Femtosecond lasers have recently emerged as a powerful microfabrication tool due to their unique characteristics. On the one hand, they enable to induce a permanent refractive index increase, in a micrometer-sized volume of the material, allowing single-step, three-dimensional fabrication of optical waveguides. On the other hand, femtosecond-laser irradiation of fused silica followed by chemical etching enables the manufacturing of directly buried microfluidic channels. This opens the intriguing possibility of using a single laser system for the fabrication and three-dimensional integration of optofluidic devices. This paper will review the state of the art of femtosecond laser fabrication of optical waveguides and microfluidic channels, as well as their integration for high sensitivity detection of biomolecules and for cell manipulation.

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Section: Label-free Sensing With Mach-zehnder Interferometersmentioning

confidence: 99%

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Osellame

Hoekstra

Cerullo

et al. 2011

Laser & Photonics Reviews

290

226

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“…[92][93][94][95][96][97][98] Molecular organic transformations with heterogeneous catalystimmobilized flow microreactors are representative examples of these systems, where the efficiency of various organic transformations has been found to increase due to the vast interfacial area and the close distance of the molecular diffusion path in the narrow space of the flow microreactor. [99][100][101][102][103][104][105][106][107][108][109][110] If a heterogeneous catalyst was immobilized as a membranous composite at the interface of an organic layer and aqueous layer (the center of the microchannel), two reactants could be oppositely charged into and flow through the divided channel, all the while in contact with the vast interfacial surface of the catalytic membrane from both front and back sides, thereby realizing an instantaneous chemical reaction.…”

Section: Development Of Catalytic Membrane-installed Microflow Reactomentioning

confidence: 99%

Development of Batch and Flow Immobilized Catalytic Systems with High Catalytic Activity and Reusability

Yamada

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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My mission in catalysis research is to develop highly active and reusable supported catalytic systems in terms of fundamental chemistry and industrial application. For this purpose, I developed three types of highly active and reusable supported catalytic systems. The first type involves polymeric base-supported metal catalysts: Novel polymeric imidazole-Pd and Cu complexes were developed that worked at the mol ppm level for a variety of organic transformations. The second involves catalytic membrane-installed microflow reactors: Membranous polymeric palladium and copper complex/nanoparticle catalysts were installed at the center of a microtube to produce novel catalytic membrane-immobilized flow microreactor devices. These catalytic devices mediated a variety of organic transformations to afford the corresponding products in high yield within 1-38 s. The third is a silicon nanowire array-immobilized palladium nanoparticle catalyst. This device promoted a variety of organic transformations as a heterogeneous catalyst. The Mizoroki-Heck reaction proceeded with 280 mol ppb (0.000028 mol%) of the catalyst, affording the corresponding products in high yield.

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“…In order to enhance mixing in continuous flow micro-reactors, channels of different shapes (Y and T) are used and, sometimes, a micro-mixer is integrated in the system as well. Micro-mixers can reduce the mixing time to milli-or even, nanoseconds [9]. However, due to non-uniform velocity profiles, there is a broad residence time distribution, leading to an equally broad particle size distribution.…”

Section: Introductionmentioning

confidence: 99%

Microfluidics-Nano-Integration for Synthesis and Sensing

Bădilescu

Packirisamy

2012

Polymers

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Abstract:The recent progress and achievements in the development of preparation of nano and microparticles in a microfluidic environment is reviewed. Microfluidics exploit fluid mechanics to create particles with a narrow range of sizes and offers a finely controllable route to tune the shape and composition of nanomaterials. The advantages of both continuous flow-and droplet-based synthesis of polymers and nanoparticles, in comparison with the traditional stirred flasks methods are discussed in detail by using numerous recent examples from the literature as well as from the authors' work. The controllability of the size distribution of the particles is discussed in terms of the fabrication approach and the characteristics of the microfluidic reactors. A special attention is paid to metal-polymer nanocomposites prepared through microfluidic routes and their application in bio-sensing. Directions for future development of microfluidic synthesis of high quality nanoparticles are discussed.

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The application of micro reactors to synthetic chemistry

Abstract: A feature article describing the fundamental characteristics and emerging applications of micro technology in the field of synthetic chemistry.

Cited by 235 publications

References 47 publications

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Development of Batch and Flow Immobilized Catalytic Systems with High Catalytic Activity and Reusability

Microfluidics-Nano-Integration for Synthesis and Sensing

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