The Application of Nanomaterials in Stem Cell Therapy for Some Neurological Diseases

Zhang, Guilong; Khan, Aamir Hameed; Wu, Hao; Chen, Lukui; Gu, Yan; Gu, Ning

doi:10.2174/1389450118666170328115801

Cited by 26 publications

(13 citation statements)

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“…Similarly, research on stem cell therapy utilizing nanoparticles is also on the rise. Because of the small size and target specificity of the nanoparticles, scientists are aiming to treat some neurological diseases using this strategy [108].…”

Section: Gene Therapymentioning

confidence: 99%

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

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Section: Gene Therapymentioning

confidence: 99%

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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“…Stem cell therapies have been a famous treatment option for various CNS diseases (Lee et al, 2017;Wei et al, 2017;Sonntag et al, 2018;Sugaya and Vaidya, 2018;Zhang et al, 2018).…”

Section: Stem Cell Derived Exosome Is Neuro Protective Via Astrocytesmentioning

confidence: 99%

The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases

Gharbi

Zhang

Yang

2020

Front. Cell Dev. Biol.

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Astrocyte activation plays an important role during disease-induced inflammatory response in the brain. Exosomes in the brain could be released from bone marrow (BM)derived stem cells, neuro stem cells (NSC), mesenchymal stem cells (MSC), etc. We summarized that exosomes release and transport signaling to the target cells, and then produce function. Furthermore, we discussed the pathological interactions between astrocytes and other brain cells, which are related to brain diseases such as stroke, Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) disease, multiple sclerosis (MS), psychiatric, traumatic brain injury (TBI), etc. We provide up-to-date, comprehensive and valuable information on the involvement of exosomes in brain diseases, which is beneficial for basic researchers and clinical physicians.

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“…Stem cells have become the primary choice for transplantation therapy because of their "infinite" proliferation and multi-prospective differentiation potential. Moreover, stem cell transplantation therapy has been shown to promote the recovery of damaged tissues [52,53], including spinal cord, heart, brain, and liver. Previous researches have shown that cell proliferation can be found in subventricular zone in rat model disposed by the middle cerebral artery occlusion (MCAO), suggesting that endogenous recovery process is started after stroke [54][55][56][57].…”

Section: Exosomes Transplantation Therapy Directlymentioning

confidence: 99%

Therapeutic potential role of exosomes for ischemic stroke

Zhu

Kalyan

Chen

2019

Brain Science Advances

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Exosomes are extracellular vesicles with a diameter of 30–100 nm, which are released into the extracellular space by fusion of multivesicular and plasma membranes. These vesicles actually play a distinct role in cell communication, although they were considered as membrane debris in the past. The endosomal sorting complex required for transport (ESCRT)-dependent and ESCRT-independent mechanisms are currently considered to be involved in the sorting of exosomes, and the release of exosomes is related to the members of Rab protein family and SNARE family. In recent years, the therapeutic potential of exosomes has become apparent. For example, via the direct transplantation of exosomes, the ischemic area after stroke is reduced, and the neurological function is improved significantly. Furthermore, they can be used as effective drug delivery vehicles due to their unique characteristics such as low immunogenicity and nanometer size. In conclusion, exosomes provide a cell-free treatment for ischemic stroke.

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The Application of Nanomaterials in Stem Cell Therapy for Some Neurological Diseases

Abstract: Nano-stem cell-based therapy as a promising strategy has the ability to affect neuronal repair and regeneration in the central nervous system.

Cited by 26 publications

References 0 publications

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases

Therapeutic potential role of exosomes for ischemic stroke

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