The Application of Negative Pressure Wound Therapy in the Treatment of Chronic Venous Leg Ulceration: Authors Experience

Kucharzewski, Marek; Mieszczański, Paweł; Wilemska-Kucharzewska, Katarzyna; Taradaj, Jakub; Kuropatnicki, Andrzej K.; Śliwiński, Zbigniew

doi:10.1155/2014/297230

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…Among the 58 patients included in the study 8 patients expired (13.8% mortality rate). 3,11,12 There was a definite male preponderance with almost 41 (82.00%) patients being males in our study. Such predominance of NF among male population has no particular reason but can be due to them being more prone to trauma.…”

Section: Resultssupporting

confidence: 45%

Comparison of vacuum assisted closure therapy with conventional dressing in the management of necrotizing fasciitis wound

et al. 2021

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Background: The purpose of our study was to compare the effect of vacuum assisted closure (VAC) therapy and conventional dressings in patients with open wounds due to necrotizing fasciitis (NF) on the basis of healing rate, infection control, frequency of dressing and pain score.Methods: The study evaluated 50 patients admitted with NF requiring surgery over a period of 18 months. The patients were randomized to two groups. In group A patients, the wounds were managed with conventional dressings and in group B patients, negative pressure wound therapy (NPWT) was applied. Serial assessment of both groups was done for four weeks. The parameters including size of wound, wound bed, granulation tissue formation, color, amount and odor of exudate, edema, frequency of dressing, re-debridement and pain were monitored and analysed.Results: In our study, patients with NF wounds who underwent VAC therapy had earlier granulation tissue formation, resolution of infection and readiness for skin grafting. The frequency of dressing, requirement of re-debridement, resolution of edema, odor, skin maceration, inflammation around wound and pain significantly reduced in group B (VAC) when compared to conventional dressing group.Conclusions: When compared to the conventional dressing on NF wound, application of VAC helped in early appearance of granulation tissue, significant reduction of inflammation, wound odor, exudate, need for re-debridement, frequency of dressing and pain. Thus, VAC dressing can be considered as a better option in the management of NF wounds.

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Section: Resultssupporting

confidence: 45%

Comparison of vacuum assisted closure therapy with conventional dressing in the management of necrotizing fasciitis wound

et al. 2021

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“…These mechanisms improve topical wound state and facilitate the healing process [ 11 , 18 , 31 , 32 ]. Other names for this therapy found in the literature are: vacuum-assisted closure (VAC), vacuum sealing technique (VST), vacuum pack therapy, sealed surface wound suction (SSS), subatmospheric pressure dressing (SPD), foam suction dressing, or sealing aspirative therapy [ 33 ].…”

Section: Negative Pressure Wound Therapymentioning

confidence: 99%

“…An airtight dressing surrounds the wound and its exudate is drained into the container through a pipe. The dressing applied to the wounds is usually changed every 48–72 h, and the treatment duration is at least several weeks [ 32 , 33 ]. Due to the specificity of VAC treatment, compression therapy as the primary treatment of VLUs is not applied in parallel.…”

Section: Negative Pressure Wound Therapymentioning

confidence: 99%

Venous Leg Ulcers: Advanced Therapies and New Technologies

2021

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The prevalence of venous leg ulcers (VLUs) differs between 1.5% and 3% in the general population. The challenge in treating VLUs is common recurrence. Moreover, VLUs can be resistant to healing, despite appropriate treatment. In these cases, advanced wound therapies should be considered. The number of new technologies, applied in VLUs treatment, has increased in the last years. These therapies include biophysical interventions such as ultrasound therapy, electrical stimulations, electromagnetic therapy, or phototherapy. Furthermore, stem cell therapies, biologic skin equivalents, platelet-rich plasma therapy, oxygen therapies, anti-TNF therapy, or negative pressure wound therapy are advanced venous ulcer therapeutic methods that may support the standard of care. Medical devices, such as a muscle pump activator, or intermittent pneumatic compression device, may be especially useful for specific subgroups of patients suffering from VLUs. Some of the above-mentioned technologies require broader evidence of clinical efficacy and are still considered experimental therapies in dermatology.

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“…Kieser et al demonstrated that the addition of t‐NPWT in the management of resistant chronic venous ulcers being treated with compression therapy produced rapidly improving ulcers with a clean, granulating base. In another group of patients with nonhealing venous ulcers previously treated with elastic compression Kucharzewski et al achieved complete healing in all ulcers by 20 weeks.…”

Section: Introductionmentioning

confidence: 97%

A prospective, randomized, controlled clinical trial on the efficacy of a single‐use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities

Kirsner

Dove²,

Reyzelman

et al. 2019

Wound Repair Regeneration

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Multicenter, phase‐4, randomized, comparative‐efficacy study in patients with VLUs or DFUs comparing for noninferiority the percentage change in target ulcer dimensions (area, depth, and volume) a single‐use negative pressure wound therapy (s‐NPWT) system versus traditional NPWT (t‐NPWT) over a 12‐week treatment period or up to confirmed healing. Baseline values were taken at the randomization visit. Randomized by wound type and size, 164 patients with non‐infected DFUs and VLUs were included. The ITT population was composed of 161 patients (101 with VLUs, 60 with DFUs) and 115 patients completed follow‐up (64 in the s‐NPWT group and 51 in the t‐NPWT group) (PP population). The average age for all patients was 61.5 years, 36.6% were women, and treatment groups were statistically similar at baseline. Primary endpoint analyses on wound area reduction demonstrated statistically significant reduction in favor of s‐NPWT (p = 0.003) for the PP population and for the ITT population (p < 0.001). Changes in wound depth (p = 0.018) and volume (p = 0.013) were also better with s‐NPWT. Faster wound closure was observed with s‐NPWT (Cox Proportional Hazards ratio (0.493 (0.273, 0.891); p = 0.019) in the ITT population. Wound closure occurred in 45% of patients in the s‐NPWT group vs. 22.2% of patients in the t‐NPWT group (p = 0.002). Median estimate of the time to wound closure was 77 days for s‐NPWT. No estimate could be provided for t‐NPWT due to the low number of patients achieving wound closure. Device‐related AEs were more frequent in the t‐NPWT group (41 AEs from 29 patients) than in the s‐NPWT group (16 AEs from 12 patients). The s‐NPWT system met noninferiority and achieved statistical superiority vs. t‐NPWT in terms of wound progression toward healing over the treatment period. When NPWT is being considered for the management of challenging VLUs and DFUs, s‐NPWT should be considered a first choice over other types of NPWT.

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The Application of Negative Pressure Wound Therapy in the Treatment of Chronic Venous Leg Ulceration: Authors Experience

Cited by 10 publications

References 10 publications

Comparison of vacuum assisted closure therapy with conventional dressing in the management of necrotizing fasciitis wound

Comparison of vacuum assisted closure therapy with conventional dressing in the management of necrotizing fasciitis wound

Venous Leg Ulcers: Advanced Therapies and New Technologies

A prospective, randomized, controlled clinical trial on the efficacy of a single‐use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities

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