The Application of Pattern Recognition Techniques in the Analysis of Metacarpophalangeal Lengths

Landry, Danny J.; Vanhoutte, Jean J.; Raeside, D. E.

doi:10.1097/00004424-197907000-00004

Cited by 5 publications

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“…The results of multivariate discriminant analysis in our study show that MCPP analysis is a sensitive and specific method. The sensitivity of MCPP analysis in our study was slightly lower than that reported for other skeletal dysplasias (3,13). The MCPP variability observed in our patients is concordant with the previously reported variation of the phenotype in LWD (10,21,22).…”

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confidence: 89%

Metacarpophalangeal pattern profile analysis in leri‐weill dyschondrosteosis

et al. 2005

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Section: Discussionsupporting

confidence: 89%

Metacarpophalangeal pattern profile analysis in leri‐weill dyschondrosteosis

et al. 2005

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“…Discriminant analysis was also used by Landry et al (1979) to separate hand patterns among several syndromes (Down, Turner, achondroplasia, and normal). Their analysis of the MCPP data resulted in approximately 20% improvement in classification over the use of correlation studies (Landry et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

“…Their analysis of the MCPP data resulted in approximately 20% improvement in classification over the use of correlation studies (Landry et al, 1979). Their results suggested that certain congenital malformation syndromes may be grouped with good accuracy on the basis of MCPP data, and encouraged the development of an automated system for pattern recognition in the diagnosis of certain syndromes.…”

Section: Discussionmentioning

confidence: 99%

“…A number of biological anthropologists were instrumental in the development and application of this method (Garn et al, 1972). More recently a number of investigators have broadened the analysis of hand bone lengths by applying multivariate statistical methods in an effort to provide an additional diagnostic tool for certain disorders (Landry et al, 1979; Butler et al, 1982).The hand is a complex anatomical structure. There are 28 component bones susceptible to a combination of factors (e.g., environmental and genetic) that may alter length and width.…”

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“…Poznanski (1984) has emphasized the superiority of discriminant analysis in correctly classifying affected and normal individuals as compared with correlation studies. Similarly he stressed the potential of multivariate statistical methods for improving the recognition of similarities and differences between patterns.Discriminant analysis was also used by Landry et al (1979) to separate hand patterns among several syndromes (Down, Turner, achondroplasia, and normal). Their analysis of the MCPP data resulted in approximately 20% improvement in classification over the use of correlation studies (Landry et al, 1979).…”

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Metacarpophalangeal pattern profile analysis in clinical genetics: An applied anthropometric method

Butler

Meaney

Kaler

1986

American J Phys Anthropol

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The hand is a complex anatomical structure with the component bones susceptible to a combination of environmental and genetic factors that may affect the bone length and width. The alterations may involve a single bone or specific group of bones. The metacarpophalangeal pattern profile (MCPP) developed by Poznanski, Garn, and others (Poznanski et al. Birth Defects VIII (5): [125][126][127][128][129][130][131] 1972) is a graphic representation of the relative lengthening and shortening of the 19 tubular bones of the hand useful for diagnosis, comparison of dissimilar patients, and gene carrier detection. The profile hand bone measurements are derived from posteroanterior hand radiographs and are standardized for age and sex. Specific profiles have been developed for several syndromes. Therefore, MCPP analysis has developed from a method of describing changes in the hand to a technique useful in assigning a diagnosis to a specific syndrome and evaluation of skeletal development. The current status of MCPP analysis in clinical genetics, particularly with the Prader-Labhart-Willi and Sotos syndromes, is discussed. KeywordsPrader-Labhart-Willi syndrome; Sotos syndrome; Discriminant analysis; Correlation studies Metacarpophalangeal pattern profile analysis (MCPP) is an application of an anthropometric technique that has been utilized increasingly in clinical genetics to evaluate individuals with a variety of congenital malformation syndromes. A number of biological anthropologists were instrumental in the development and application of this method (Garn et al., 1972). More recently a number of investigators have broadened the analysis of hand bone lengths by applying multivariate statistical methods in an effort to provide an additional diagnostic tool for certain disorders (Landry et al., 1979; Butler et al., 1982).The hand is a complex anatomical structure. There are 28 component bones susceptible to a combination of factors (e.g., environmental and genetic) that may alter length and width. The alterations may involve a single bone or specific group of bones in a digit (e.g., HoltOram syndrome) or within a row of bones such as the metacarpals (Proger et al., 1968;Poznanski et al., 1970). There are syndromes in which non-homologous segments of the hand are affected and others characterized by size reduction of a single segment such as the middle phalanx of the fifth digit (Garn et al., 1972). HHS Public AccessInvestigators in the past have attempted to examine specific hand bones in syndromes, for example, Down syndrome and the "metacarpal sign" or gradient of metacarpal shortening in Turner syndrome described by Archibald et al. (1959). Ratios of length and width of major hand bones have also been examined in Marfan syndrome and other connective tissue disorders (Parish, 1967).These methods were helpful in certain conditions, but there was a need to describe the overall relationship of the hand bone lengths. Subtle changes may be detected by examining the overall relationship that may be overlooked in the ro...

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Metrical variation in the thumb, index, and middle finger among four samples of both sexes

Smith

1991

Skeletal Radiol.

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Metrical length and width parameters of the first through third ray metacarpals and phalanges are presented for four samples of adults of both sexes drawn from radiographs of the Ten State Nutrition Survey (1968-1970). Radiographic measurements were obtained with the aid of a digitizer and computer translation program. The establishment of ranges of variation among these samples allows their use in clinical diagnosis, for example of syndromes via pattern profile analysis. Proportional analyses of hand metrics can now be extended to include widths of the first three rays as well as lengths, and data for such a purpose are now available for American blacks. Mexican-Americans, and Oriental-Americans in addition to American white groups. Examples of intersample variation are given; the need to consider such variation in clinical contexts is emphasized.

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The Application of Pattern Recognition Techniques in the Analysis of Metacarpophalangeal Lengths

Cited by 5 publications

References 0 publications

Metacarpophalangeal pattern profile analysis in leri‐weill dyschondrosteosis

Metacarpophalangeal pattern profile analysis in leri‐weill dyschondrosteosis

Metacarpophalangeal pattern profile analysis in clinical genetics: An applied anthropometric method

Metrical variation in the thumb, index, and middle finger among four samples of both sexes

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